Effect of high-refined carbohydrate diet on intestinal integrity

Costa, Kátia Anunciação; Oliveira, Marina C.; Cordeiro, Letícia Maria de Souza; Val, Cynthia H; Machado, Fabiana S.; Fernandes, Simone Odília Antunes; Cardoso, Valbert Nascimento; Teixeira, Mauro M.; Silveira, Ana Letícia Malheiros; Ferreira, Adaliene Versiani Matos

doi:10.1016/j.nut.2023.112084

Cited by 3 publications

(1 citation statement)

References 45 publications

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“…In other models of diet-induced obesity in the absence of pregnancy, studies have shown heterogeneous results. In mice fed a diet rich in refined carbohydrates there was only a minor increase in gamma-interferon, with no changes in Tnfa [34]; in another study, mice fed a HFD for 8 weeks presented increased colonic expression of Tnfa, Il-1β, and Il-6 [35]. In yet another study, mice fed for a short period on a HFD presented only minor changes in colonic cytokine expression [36].…”

Section: Discussionmentioning

confidence: 91%

Pregnancy Protects against Abnormal Gut Permeability Promoted via the Consumption of a High-Fat Diet in Mice

Biolcatti,

Bobbo,

Solon

et al. 2023

Nutrients

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The consumption of large amounts of dietary fats and pregnancy are independent factors that can promote changes in gut permeability and the gut microbiome landscape. However, there is limited evidence regarding the impact of pregnancy on the regulation of such parameters in females fed a high-fat diet. Here, gut permeability and microbiome landscape were evaluated in a mouse model of diet-induced obesity in pregnancy. The results show that pregnancy protected against the harmful effects of the consumption of a high-fat diet as a disruptor of gut permeability; thus, there was a two-fold reduction in FITC–dextran passage to the bloodstream compared to non-pregnant mice fed a high-fat diet (p < 0.01). This was accompanied by an increased expression of gut barrier-related transcripts, particularly in the ileum. In addition, the beneficial effect of pregnancy on female mice fed the high-fat diet was accompanied by a reduced presence of bacteria belonging to the genus Clostridia, and by increased Lactobacillus murinus in the gut (p < 0.05). Thus, this study advances the understanding of how pregnancy can act during a short window of time, protecting against the harmful effects of the consumption of a high-fat diet by promoting an increased expression of transcripts encoding proteins involved in the regulation of gut permeability, particularly in the ileum, and promoting changes in the gut microbiome.

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Section: Discussionmentioning

confidence: 91%

Pregnancy Protects against Abnormal Gut Permeability Promoted via the Consumption of a High-Fat Diet in Mice

Biolcatti,

Bobbo,

Solon

et al. 2023

Nutrients

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Effect of digested chia seed protein on the gut microbiota and colon morphology of mice fed a high-saturated-fat diet

Grancieri,

de São José,

Toledo

et al. 2024

Food Funct.

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High-concentrate diet supplemented with hydrolysable tannin improves the slaughter performance, intestinal antioxidant ability and barrier function of fattening lambs

Ma,

Li,

Lin

et al. 2024

Front. Vet. Sci.

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The objective of current experiment was to study the potential influence of hydrolysable tannin supplementation on slaughter performance, meat quality, intestinal digestive enzyme activity, antioxidant ability and barrier function in fattening lambs. In total, 36 male Hu sheep lambs with similar body weight (15.83 ± 0.48 kg) and days in age (55 ± 2 d) were randomly assigned to one of three groups of 12 animals each: control without tannin (CON) and tannin supplementation groups (TA1, 3 g/d per lamb; TA2, 6 g/d per lamb). All the lambs were reared in individual hutches, and the experiment lasted for 60 d. On d 61, 8 lambs from each group were randomly selected to slaughter. Results showed that the serum diamine oxidase and lipopolysaccharide contents of TA2 group were higher (p < 0.05) than those of CON group. Compared with CON group, the carcass weight and intramuscular fat content of lambs in TA1 group were increased (p < 0.05) and the meat shear force was decreased (p < 0.05). The trypsin activity in the jejunum and ileum of TA1 group was higher (p < 0.05) than that of CON and TA2 groups. Also, tannin supplementation significantly increased (p < 0.05) the level of jejunal and ileal total antioxidant capacity and reduced (p < 0.05) the jejunal malondialdehyde concentration in lambs. The jejunum and ileum of TA1 lambs showed reduced (p < 0.05) tumor necrosis factor-alpha and increased (p < 0.05) interleukin-10 mRNA levels compared with CON lambs. In the jejunum, the secretory immunoglobulin A content of TA1 group was higher (p < 0.05) than that of CON and TA2 groups. Lambs supplemented with tannin at the level of 3 g/d increased (p < 0.05) the gene expressions of claudin-1, claudin-4 and zonula occludens-1 in the jejunum when compared to those of CON and TA2 groups. In summary, tannin supplementation at the level of 3 g/d per animal can improve the production performance and intestinal function of fattening lambs fed a high-concentrate diet.

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Effect of high-refined carbohydrate diet on intestinal integrity

Cited by 3 publications

References 45 publications

Pregnancy Protects against Abnormal Gut Permeability Promoted via the Consumption of a High-Fat Diet in Mice

Pregnancy Protects against Abnormal Gut Permeability Promoted via the Consumption of a High-Fat Diet in Mice

Effect of digested chia seed protein on the gut microbiota and colon morphology of mice fed a high-saturated-fat diet

High-concentrate diet supplemented with hydrolysable tannin improves the slaughter performance, intestinal antioxidant ability and barrier function of fattening lambs

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