Effect of High Sodium Intake on Gut Tight Junctions’ Structure and Permeability to Bacterial Toxins in a Rat Model of Chronic Kidney Disease

Villela-Torres, María de la Luz; Prado-Uribe, María-del-Carmen; Díaz, Marcela Ávila; Pablo, Héctor Quezada; Soria-Castro, Elizabeth; Escofet, Nuria Esturau; Maldonado, Catalina Elizabeth Flores; Paniagua, Ramón

doi:10.1016/j.arcmed.2024.102969

Archives of Medical Research

2024

DOI: 10.1016/j.arcmed.2024.102969

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Effect of High Sodium Intake on Gut Tight Junctions’ Structure and Permeability to Bacterial Toxins in a Rat Model of Chronic Kidney Disease

María de la Luz Villela-Torres,

María-del-Carmen Prado-Uribe,

Marcela Ávila Díaz

et al.

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Optimization of Desalting Conditions for the Green Seaweed Codium fragile for Use as a Functional Food with Hypnotic Effects

Park,

Kim,

Kim

et al. 2024

Foods

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Codium fragile (CF) contains various bioactive compounds, but its high salt content (39.8%) makes its use as a functional food challenging. Here, we aimed to optimize the desalination process and verify changes in functionality based on variations in salt and total phenolic contents. To optimize the CF immersion conditions for the lowest salt content and monitor the total phenolic content, a response surface methodology was used. The optimal immersion conditions were as follows: X1 (immersion temperature) = 42.8 °C; X2 (immersion time) = 1.0 h. An inverse correlation was noted between salt content and total phenolic content. Among the post-desalination processes, desalination with centrifugal dehydration (CD) significantly reduced salt content. CD ethanol extract (CD-E) induced the longest sleep duration in the pentobarbital-induced sleep test in ethanol extracts. Moreover, 1000 mg/kg CD-E had a significant effect on non-rapid eye movement sleep but did not affect delta activity. These findings highlight the potential of industrializing CF as a functional food through desalination and its promise as a natural aid for sleep promotion.

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Optimization of Desalting Conditions for the Green Seaweed Codium fragile for Use as a Functional Food with Hypnotic Effects

Park,

Kim,

Kim

et al. 2024

Foods

View full text Add to dashboard Cite

show abstract

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Effect of High Sodium Intake on Gut Tight Junctions’ Structure and Permeability to Bacterial Toxins in a Rat Model of Chronic Kidney Disease

Cited by 1 publication

References 35 publications

Optimization of Desalting Conditions for the Green Seaweed Codium fragile for Use as a Functional Food with Hypnotic Effects

Optimization of Desalting Conditions for the Green Seaweed Codium fragile for Use as a Functional Food with Hypnotic Effects

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