Effect of High VEGF-C mRNA Expression on Achievement of Complete Remission in Adult Acute Myeloid Leukemia

Lee, Sung‐Eun; Lee, Ji Yoon; Han, A-Reum; Hwang, Hyung Bin; Min, Woo-Sung; Kim, Hee-Je

doi:10.1016/j.tranon.2018.02.018

Cited by 2 publications

(1 citation statement)

References 42 publications

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“…These findings were well-established in our previous reports, which showed a correlation between the induction chemotherapy response and VEGF-C expression in adult AML. The findings further support our thesis that the influx of VEGF-C from the surface of the AML blasts to intracellular migration mechanism in different ways in good vs. bad initial treatment responses should be considered ( 18 ). It is not confirmed yet, but the BM may play a critical role in the development of all hematopoietic cells, including NK cells when under the optimal microenvironment for their functional maturation.…”

Section: Discussionsupporting

confidence: 83%

Peptides Targeting Fms-Related Tyrosine Kinase-4 Activate the Function of Natural Killer Cells in Acute Myeloid Leukemia

Park

Kim

Hwang

et al. 2021

IJSC

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Background and Objectives: The increased expression for the Fms-related tyrosine kinase-4 (FLT-4, known as VEGFR-3) is relevant to dysfunctional natural killer (NK) cells in acute myeloid leukemia (AML). MAZ51 (M), a VEGFR-3 inhibiting chemical, was effectively restored the function of NK cells via the high expression of interferon-gamma (IFN-γ) in NK cells, as shown in our previous study. Although tremendous amount of clinical data using peptides are currently available in real clinic, peptides targeting FLT-4 in modulating immune cells such as NK cells are not fully elucidated. Methods and Results: In present study, we developed peptides targeting FLT-4 (P), which is inhibiting an affinity for AML-NK expressing FLT-4 in vitro and in vivo. Bone marrow (BM) and peripheral blood (PB) mononuclear cells (MNCs) from AML patients were treated with combinational cocktails of the three agents including P, M, ara-C (A) and FLT-4 expression and IFN-γ release were examined. In an AML mouse model, IFN-γ expression were examined in T and NK cells from mouse BM, spleen, and liver to address relevance between peptides and immune cell activation. We found that AML-NK cells both in human and mouse samples showed a gradual increase the IFN-γ levels compared to the controls. There was a trend toward a reduction in leukemic blasts in the BM, spleen, and liver from the AML mice, when we compared the effects of combinational treatments. Conclusions: Our results suggest that the function of AML-NK cells was synergistically activated by P in combination with M or A.

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Section: Discussionsupporting

confidence: 83%

Peptides Targeting Fms-Related Tyrosine Kinase-4 Activate the Function of Natural Killer Cells in Acute Myeloid Leukemia

Park

Kim

Hwang

et al. 2021

IJSC

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7‑Difluoromethyl‑5,4'‑dimethoxygenistein exerts anti‑angiogenic effects on acute promyelocytic leukemia HL‑60 cells by inhibiting the TLR4/NF‑κB signaling pathway

Xiang

et al. 2020

Mol Med Report

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angiogenesis plays an important role in the development and metastasis of tumors, and anti-angiogenesis agents are used to treat tumors. For example, the acute promyelocytic leukemia (aPl) may be treated with arsenic trioxide. angiogenesis in aPl is a multi-step dynamic equilibrium process coordinated by various angiogenic stimulators and inhibitors, which play key roles in the occurrence, progression and chemosensitivity of this disease. our research group previously synthesized 7-difluoromethyl-5,4'-dimethoxygenistein (dFMG), and found that it inhibits angiogenesis during atherosclerotic plaque formation. in the present study, the effect and mechanism of dFMG in angiogenesis induced by aPl Hl-60 cells was investigated using a chick embryo chorioallantoic membrane model and Matrigel tubule formation assays. The results obtained revealed an anti-angiogenesis effect of dFMG towards Hl-60 cells. When the Toll-like receptor 4/nuclear factor-κB (TLR4/nF-κB) signaling pathway was inhibited, the anti-angiogenic effect of dFMG was further enhanced. However, when the TLR4/nF-κB signaling pathway was activated, the anti-angiogenic effect of dFMG was attenuated. These results demonstrated that dFMG inhibits angiogenesis induced by aPl Hl-60 cells, and provides insights into the mechanism by which dFMG inhibits the TLR4/nF-κB signaling pathway. in conclusion, in the present study, the anti-angiogenesis effect of dFMG on aPl has been reported, and the mechanism by which dFMG induced the anti-angiogenesis effect was explored. These findings have provided a potential new drug candidate for the treatment of patients with aPl.

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Effect of High VEGF-C mRNA Expression on Achievement of Complete Remission in Adult Acute Myeloid Leukemia

Cited by 2 publications

References 42 publications

Peptides Targeting Fms-Related Tyrosine Kinase-4 Activate the Function of Natural Killer Cells in Acute Myeloid Leukemia

Peptides Targeting Fms-Related Tyrosine Kinase-4 Activate the Function of Natural Killer Cells in Acute Myeloid Leukemia

7‑Difluoromethyl‑5,4'‑dimethoxygenistein exerts anti‑angiogenic effects on acute promyelocytic leukemia HL‑60 cells by inhibiting the TLR4/NF‑κB signaling pathway

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