Effect of high velocity–low amplitude treatment on superoxide dismutase and glutathione peroxidase activities in erythrocytes from men with neck pain

Peripheral Oxidative Stress Blood Markers in Patients With Chronic Back or Neck Pain Treated With High-Velocity, Low-Amplitude Manipulation

“…28 However, we described only a tendency to an increase in GPx activity. 29 In the present study, HVLA spinal manipulation for 5 weeks did not induce a significant change in catalase but did increase GPx activity. These changes can regulate the concentrations of H 2 O 2 in erythrocytes.…”

“…However, GPx activity showed a tendency to increase with a shorter period of treatment. 28,29 These results suggest that the effect of HVLA spinal manipulation on antioxidant enzyme activities may be affected by the length of time and the frequency of treatment.…”

“…65 Interestingly, comparison between this and our previous results shows that the reduction of IL-6 coincided with the tendency to reduction in SOD activity. 29 Thus, it is possible that the lower SOD activity after the patients with neck pain who were treated by HVLA spinal manipulation for 2 weeks may be due to the reduction in proinflammatory cytokines, probably IL-6. It would be interesting to examine the relationship between proinflammatory cytokines and RS parameters in patients treated by HVLA spinal manipulation.…”

“…28 Glutathione peroxidase activity, in turn, seemed to require a longer period of treatment (N 2 weeks) because only a tendency to increased activity was found in the period considered. 29 These results led us to hypothesize that the effects of HVLA spinal manipulation on antioxidant activity may depend on the treatment period. Therefore, to provide more information about this hypothesis, the purpose of this study was to assess RS in blood of patients with nonspecific chronic neck or back pain treated by HVLA spinal manipulation for 5 weeks, twice a week, to analyze the activity of the antioxidant enzymes SOD, catalase and GPx, the levels of NO metabolites, and the formation of lipid hydroperoxides (LOOHs), which are formed by the action of reactive oxygen species on polyunsaturated fatty acids, 30 in the blood of the patients before and after the treatment.…”