Effect of High-Volume and -Intensity Endurance Training in Heart Transplant Recipients

Pokan, Rochus; Duvillard, Serge P. von; Ludwig, Jutta; Rohrer, Andrea; Hofmann, Peter; Wonisch, Manfred; Smekal, Gerhard; Schmid, Peter; Pacher, Richard; Bachl, Norbert

doi:10.1249/01.mss.0000147630.71210.06

Cited by 34 publications

(18 citation statements)

References 26 publications

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“…Our finding of functional evidence of cardiac reinnervation (i.e., Ͼ36 beat/min increase in exercise HR; Fig. 3A) (38,48) in eight of nine of our HTR may account for the similar peak HR between HTR and RM controls. Also, the fact that HTR may only have partial and nonuniform reinnervation (2) could explain why HTR have a significantly lower peak HR than DM controls.…”

Section: Discussionmentioning

confidence: 55%

Cardiovascular responses to incremental and sustained submaximal exercise in heart transplant recipients

Scott¹,

Esch²,

Haykowsky³

et al. 2009

American Journal of Physiology-Heart and Circulatory Physiology

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The cardiovascular response to exercise in heart transplant recipients (HTR) has been compared with that of healthy individuals matched to the recipient age (RM controls). However, no study has compared HTR with donor age-matched (DM) controls. Moreover, the cardiovascular response to sustained submaximal exercise in HTR requires further evaluation. We therefore examined cardiovascular responses during incremental exercise and sustained (1 h) submaximal aerobic exercise in 9 clinically stable HTR [63 +/- 10 yr of age, 24.2 +/- 10.9 ml x kg(-1) x min(-1) peak O(2) uptake (Vo(2peak))] and 11 healthy age-matched controls (60 +/- 11 yr of age and 36.3 +/- 10.7 ml.kg(-1) x min(-1) Vo(2peak) for 6 RM controls and 35 +/- 8 yr of age and 51.1 +/- 10.4 ml x kg(-1) x min(-1) Vo(2peak) for 5 DM controls). Heart rate (HR) and left ventricular systolic and diastolic volumes (2-dimensional echocardiography) indexed to body surface area [end-systolic and end-diastolic volume indexes (EDVI and ESVI)], cardiac output (CI), ejection fraction (EF), systemic vascular resistance (SVRI), end-systolic elastance index, and arterial elastance index were determined. Although systolic function was maintained during incremental exercise, peak CI was significantly reduced (6.7 +/- 2.4 vs. 11.6 +/- 1.4 l x min(-1) x m(-2)), secondary to blunted HR, EDVI, and increased peak SVRI, in HTR compared with DM controls. The lower peak CI in HTR than in RM controls was due to blunted peak EDVI (54.1 +/- 13.2 vs. 68.6 +/- 5.7 ml/m(2)). During sustained submaximal exercise, HTR exhausted their preload reserve, a response for which changes in ESVI, HR, or EF did not fully compensate. Thus it appears that HTR are limited by impaired preload reserve, HR reserve, and vascular reserve during exercise conditions.

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Section: Discussionmentioning

confidence: 55%

Cardiovascular responses to incremental and sustained submaximal exercise in heart transplant recipients

Scott¹,

Esch²,

Haykowsky³

et al. 2009

American Journal of Physiology-Heart and Circulatory Physiology

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show abstract

“…6). Verschiedene Methoden zur Ermittlung der aeroben und anaeroben Schwelle unter Verwendung der Atemgasanalyse, der Blutlaktatkonzentration oder der Herzfrequenz sind in der Literatur beschrieben [11,12,[45][46][47][48].…”

Section: Ekgunclassified

“…Analog zum Verhalten der Laktat-Leistungskurve ergeben sich Umstellpunkte in den ventilatorischen Parametern, eine erste ventilatorische Schwelle (= "ventilatory threshold", VT1) entsprechend der aeroben Schwelle und eine zweite ventilatorische Schwelle (VT2) entsprechend der anaeroben Schwelle [12,45,46,48,52].…”

Section: Atemgasanalyseunclassified

Praxisleitlinien Ergometrie

Wonisch¹,

Berent²,

Klicpera³

et al. 2014

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“…Aerobic exercise training is also a wellestablished non-pharmacological way of increasing VO 2 in heart transplant recipients. The prescription of an adequate aerobic effort is crucial to obtain both an increase in exercise capacity and a reasonable control of exercise-related risks [8].…”

mentioning

confidence: 99%

The relationship between heart rate and oxygen consumption in heart transplant recipients during a cardiopulmonary exercise test

Carvalho

Bocchi

Pascoalino

et al. 2010

International Journal of Cardiology

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Effect of High-Volume and -Intensity Endurance Training in Heart Transplant Recipients

Abstract: Data suggest that HTR can perform high-volume and -intensity exercise training, reaching exercise performance comparable to or even exceeding values of sedentary or moderately trained healthy subjects.

Cited by 34 publications

References 26 publications

Cardiovascular responses to incremental and sustained submaximal exercise in heart transplant recipients

Cardiovascular responses to incremental and sustained submaximal exercise in heart transplant recipients

Praxisleitlinien Ergometrie

The relationship between heart rate and oxygen consumption in heart transplant recipients during a cardiopulmonary exercise test

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