Effect of Highly Selective Vagotomy on Gastric Motor Activity of Duodenal Ulcer Patients

Abstract

The effect of highly selective vagotomy on the gastric emptying time of a food-barium meal and antral myoelectrical and manometrical activities was studied in two groups of duodenal ulcer patients: one with and another without delay in gastric emptying. Controls performed 1 and 3 months after operation showed that the group of patients with non-delayed preoperative gastric emptying kept a good emptying, only with sporadic, slight and transient disturbances of the gastric myoelectric activity. Conversely, the group of patients with delayed preoperative gastric emptying showed an increase in emptying time together with marked alterations in myoelectric and manometric activities.

The Impact and Clinical Implications of Gastric Surgery on the Gastric Conduction System

“…30,89 Irregular antral activity was reported following truncal and complete gastric vagotomy by Hegglin et al 45 and Wilbur and Kelly 85 however this was not observed in any studies of highly selective vagotomy. 30,84,85,88,89 Tachygastria has been reported relatively consistently following vagotomy, 84,[89][90][91] and bradygastria was observed by Bortolotti et al, 88 supporting the known role the vagus has on influencing ICC rate and rhythm. 92 Fundoplication is associated with high rates of vagal injury.…”

“…A number of studies describe the influence of vagotomy on slow wave activity, all of which used sparse electrode techniques either applied at the body surface (EGG), into the gastric muscularis, or into the mucosa by gastroscopy. A variety of post-vagotomy slow wave abnormalities have been described, 45,84,85,88 and a smaller number of studies report no convincing alteration to gastric electrical activity with vagotomy. 30,89 Irregular antral activity was reported following truncal and complete gastric vagotomy by Hegglin et al 45 and Wilbur and Kelly 85 however this was not observed in any studies of highly selective vagotomy.…”

Gastric Myoelectric Activity in Patients with Chronic Idiopathic Gastroparesis

“…Some studies have shown the possibility of recording myoelectric activity in the human gastric antrum by use of a peroral probe with electrodes held against the mucosa by negative pressure (11)(12)(13)(14)(15) or magnetic force (16). However, until now only one study has been carried out using a peroral method in patients with idiopathic gastric retention (15).…”

Nissen fundoplication improves gastric myoelectrical activity characteristics and symptoms in gastroesophageal reflux patients: evaluation in transcutaneous electrogastrography

“…In general, difficulties in interpretation occurred many times concerning motility disturbances. Bortollotti et al [28] investigated the effect of highly selective vagotomy on the gastric motor activity of duodenal ulcer patients. Two groups of patients were examined: those with and those without preoperative delayed gastric emptying.…”