Effect of hippocampal stimulation on feeding in the rat

Milgram, Norton W.

doi:10.1016/0031-9384(69)90098-5

Cited by 40 publications

(22 citation statements)

References 54 publications

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“…The present experiment does not confirm expectations based on the differential effect of stimulation of the hippocampus on eating and drinking (Milgram, 1969;Oliver, Firestone, & Goodman, 1973). Several procedural differences may account for this disparity.…”

Section: Discussioncontrasting

confidence: 92%

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The effect of hippocampal lesions on the development and extinction of a learned taste aversion for a novel food

Thomka

Brown

1975

Psychobiology

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The effect of hippocampal lesions on the inhibition of eating was examined within a learned taste aversion paradigm. Rats with hippocampal lesions were tested on their ability to refrain from eating a novel tasting food that had been paired with the internal malaise produced by a .15·M IP injection of lithium chloride. The results showed that the rats with hippocampal lesions did not differ from normal rats on either the development or extinction of the aversion. These results extend previous findings which show that bilateral hippocampal lesions do not interfere with the normal modulation of consummatory behaviors.

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Section: Discussioncontrasting

confidence: 92%

“…Several studies (Milgram, 1969;Oliver, Firestone, & Goodman, 1973) which measured the effect of hippocampal stimulation on both drinking and eating do not support a view of the hippocampus being equally involved with these two behaviors. These data indicate that the hippocampus may exert an inhibitory influence over eating while leaving drinking unaffected.…”

mentioning

confidence: 99%

The effect of hippocampal lesions on the development and extinction of a learned taste aversion for a novel food

Thomka

Brown

1975

Psychobiology

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“…This so-called "rebound-feeding" behavior is not uncommon, as similar behavior has been observed after stimulation of the hippocampus (Milgram, 1969), ventromedial hypothalamus (Morgane, 1961;Wyrwicka & Dobrzecki, 1960), anterior thalamus (Smith, McFarland, & Teitelbaum, 1961), and septum (Altman & Wishart, 1971). On the supposition that feeding behavior is largely controlled by hypothalamic activity, it has been postulated that "rebound-feeding" occurs as a consequence of either rebound excitation of the hypothalamus or disinhibition of these same neurons (Altman & Wishart , 1971 ;Milgram, 1969).…”

Section: Resultssupporting

confidence: 53%

“…Feeding behavior has also been observed during the poststimulation period at a variety of sites in the limbic system (Altman & Wishart, 1971;Milgram, 1969;Miller, 1961;Morgane, 1961;Smith, McFarland, & Teitelbaum, 1961;Wyrwicka & Dobrzecka, 1960), and this behavior is usually attributed to disinihibitiol hypothalamic foci. An alternative hypvLJlc:>l:> LV lllC predominant role of hypothalamic structures maintains that the observed behaviors are subserved by motor patterns preorganized in the brainstem and triggered by activity originating from more rostral sites (Glickman & Schiff, 1967;Valenstein, 1970;Valenstein, Cox, & Kakolewski, 1970).…”

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confidence: 99%

Substantia nigra: Self-stimulation and poststimulation feeding

Phillips

Fibiger

1973

Psychobiology

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Male Wistar rats with electrodes implanted into the substantia nigra were tested for self-stimulation and "stimulus-bound" behavior. Sixty percent of the animals learned to press a lever to deliver electrical stimulation to the substantia nigra, and these Ss were in turn screened for "stimulus-bound" feeding, drinking, and gnawing. Although no consistent "stimulus-bound" behavior was observed, several of the animals consistently displayed a moderated amount of feeding during the interstimulus intervals. The possibility of relating this behavior to activity in a nigro-striatal system is considered."Species-specific" behaviors essential for survival of both individuals and species can be readily elicited by subcortical stimulation (for reviews see Glickman &

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“…Thus in addition to its more direct effects, stimulation may have produced eating indirectly through abnormal activation of other brain structures. Both septal stimulation (Wishart et al, 1973) and hippocampal stimulation (Milgram, 1969) have also been reported to produce eating that is secondary to elicited electrographic discharges. At present it is unknown how epileptiform activity causes eating, but it may be via release of transmitter or hormonal substances in sites such as the hypothalamus to which hippocampal efferents project.…”

Section: Discussionmentioning

confidence: 99%

Eating and electroencephalographic activity following orbital frontal stimulation in rats

Cioe

Kolb

Whishaw

1980

Bull. Psychon. Soc.

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Periodic electrical stimulation of the sulcal frontal cortex produced a pronounced increase in food consumed in a I-h session as compared with both a control non stimulation period and stimulation of the medial frontal cortex. which did not elicit feeding. Stimulation of the sulcal cortex at slightly higher currents produced behavioral and electrographic seizure activity followed by eating during the postictal period_ These results support the suggested role for the sulcal (orbital) frontal cortex in feeding and complement those obtained from a number of other lines of inquiry.A number of studies have shown that orbital frontal cortex lesions disrupt feeding behavior (Brandes & Johnson, 1978;Braun, 1975;Kolb & Nonneman, 1975; Whishaw, Schallert, & Kolb, in press). Although there are important differences between the effects of lesions to the orbital frontal cortex and the lateral hypothalamic nucleus on feeding and drinking (see Whishaw et al., in press, for details), there are sufficient similarities to suggest that each makes an important contribution to the organization of feeding behavior (Kolb, Nonneman, & Whishaw, 1978;Kolb, Whishaw, & Schallert, 1977; Whishaw, Schallert, & Kolb, in press). Although it is well known that stimulation of the lateral hypothalamus induces eating and drinking in rats (e.g_ Hoebel & Teitelbaum, 1962;Margules & Olds, 1962), there have been no reports of these behaviors with electrical stimulation of the orbital frontal cortex. If the orbital frontal cortex and the hypothalamus do indeed form an interrelated circuit involved in feeding, one might expect feeding to be elicited from stimulation of the orbital frontal cortex but not from stimulation of adjacent cortical regions (such as the medial frontal cortex), which have not been implicated in feeding behavior (Kolb, 1974)_ On the other hand, stimulation of the orbital frontal cortex has been shown to suppress locomotor activity in rats (Wilcott, 1979), so that one could also predict suppression of eating as part of a lowering of general activation following orbital frontal stimulation. Accordingly, this report describes the feeding behavior of rats with orbital frontal or medial frontal stimulation. In view of the report by Wishart, Bland, Vanderwolf, and Altman (1973) bound eating can result from stimulus-induced electrographic (EEG) seizures, EEG recordings were taken during stimulation tests in some of the rats in order to determine if the stimulation induced electrographic as well as behavioral seizures. METHOD SubjectsSubjects were six adult male hooded rats weighing approximately 350 g at the time of surgery. The animals were implanted either with stimulating electrodes bilaterally in the sulcal cortex (n = 3) or with one electrode in the medial cortex and one in the sulcal cortex on the contralateral side (n = 3). The latter three rats were also implanted with recording electrodes bilaterally in the hippocampus. SurgeryThe animals were anesthetized with sodium pentobarbital (50 mg/kg) and were given 1 mg/kg atropin...

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Effect of hippocampal stimulation on feeding in the rat

Cited by 40 publications

References 54 publications

The effect of hippocampal lesions on the development and extinction of a learned taste aversion for a novel food

The effect of hippocampal lesions on the development and extinction of a learned taste aversion for a novel food

Substantia nigra: Self-stimulation and poststimulation feeding

Eating and electroencephalographic activity following orbital frontal stimulation in rats

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