Effect of Hippophae rhamnoides extract on Cisplatin-induced ototoxicity in Guinea Pigs

Abstract

No previous studies have examined the effect of Hippophae rhamnoides fruit extract (HRE), which contains both water and fat soluble vitamins, on cisplatin-induced ototoxicity. Therefore, the aim of the study was to investigate the effects of HRE on cisplatin-induced ototoxicity in Guinea pigs and to evaluate the biochemical, gene expression and histopathological changes associated with cisplatin use. Experimental animals were divided into three groups: healthy (HG), HRE+cisplatin (HRC) and cisplatin control (CCG) groups. Biochemical, gene expression and histopathological examinations were carried on the removed inner ear tissues. In the HRC group, the oxidant parameter was lower and the anti-oxidant parameter was higher than in the CCG. These results are supported by gene expression levels and histopathological results. The use of HRE against cisplatin-induced oxidative ototoxicity may be easier, more cost effective and more beneficial than the use of vitamins alone or in combination with each other.

​Evaluation of Terminalia arjuna in Comparison to Taurine against Experimental Nephrotoxicity due to Cisplatin in Rats

“…Cisplatin is a highly effective and widely used anti-neoplastic drug against various solid tumors (Erhan et al 2019). The anticancer behaviour of cisplatin originates from its ability to bind to N-7 of purine bases of cellular DNA, which leads to formation of mono-adducts that are transformed into interstrand cross links and intra-strand cross links by reaction of second reactive site of the drug with the second nucleobase (Waseem et al 2014).…”