Effect of histamine on the mitogenic response of human lymphocytes and its modification by cimetidine and levamisole

Merétey, K.; Room, G; Maini, R N

doi:10.1007/bf01991465

Cited by 24 publications

(6 citation statements)

References 18 publications

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“…The inability of histamine to suppress the responses to LPS and high doses of PHA is compatible with related studies of human lymphocytes [24]. The inability of histamine to suppress the responses to LPS and high doses of PHA is compatible with related studies of human lymphocytes [24].…”

Section: Discussionsupporting

confidence: 70%

Antimetastatic effect of cimetidine on mice bearing a C3H mouse mammary adenocarcinoma: survival and lymphocyte function studies

et al. 1984

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It has been reported that treatment with cimetidine, a histamine H2-receptor antagonist, increased survival and decreased the number of lung metastases in mice bearing the Lewis Lung carcinoma [29]. It was suggested that this effect was due to the ability of cimetidine to block histamine activation of suppressor lymphocytes and hence allow host defence mechanisms to inhibit tumour growth. In the present studies, C3H/He mice were implanted with a C3H mouse mammary adenocarcinoma on Day 0. This tumour metastasizes to the lungs in 30-50 days. Primary tumours were ablated with X-rays when they had grown to about 0.2 g and animals were given drinking water with or without cimetidine (10 mg ml-1) until the end of the experiment. Cimetidine reduced the number of mice dying from metastatic disease from 7/15 (controls) to 3/13. Cimetidine treatment also prolonged survival of mice that did succumb to metastatic disease by about 12 days. The response of spleen lymphocytes to the mitogens phytohaemagglutinin and lipopolysaccharide was assessed in vitro by uptake of 3H-thymidine 0, 16, 45 and 58 days after tumour implantation. Lymphocyte responsiveness was depressed by tumour burden. The influence of cimetidine treatment was equivocal being dependent upon time after tumour implantation and dose of mitogen. In this mouse-tumour system, the mechanism of the antimetastic effect of cimetidine is different from that previously suggested [29].

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Section: Discussionsupporting

confidence: 70%

Antimetastatic effect of cimetidine on mice bearing a C3H mouse mammary adenocarcinoma: survival and lymphocyte function studies

et al. 1984

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“…According to our former results [12], the PHA mitogenic response of human mononuclear cells was inhibited by histamine dose-dependently through H2-receptors. However, low concentration of histamine was not inhibitory but even increased the thymidine incorporation of lymphocytes [ 12].…”

Section: Discussionmentioning

confidence: 84%

“…The suppressive effect of histamine is mediated by H2-receptors of lymphocytes [8,10,12]. We could also prove that the inhibition of chemiluminescence was prevented only by cimetidine and not by mepyramine suggesting an H2-receptor specificity of the response.…”

Section: Discussionmentioning

confidence: 88%

Chemiluminescence response of human blood mononuclear cells to PHA and histamine

1983

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Phytohaemagglutinin (PHA) elicited a short early chemiluminescence (CL) response of human blood mononuclear cells with a maximum at 2.5 min. The magnitude of the CL production was a function of the PHA concentration used. The CL response could be dose-dependently inhibited by histamine. In the presence of mepyramine the action of histamine was more pronounced while a dose-dependent reversal of the inhibition was found by cimetidine.

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“…However, no-one has shown a dose-related displacement by cimetidine of a histamine dose-response curve in lymphocyte proliferation. We suspect this is partly because the combined effect of histamine plus antagonist is likely to be indecipherable over most of the concentration range, as is evident in the observations of Meretey et al [27]. Another reason is the increasing evidence that suppression can also occur via H l receptors [14,28].…”

Section: Discussionmentioning

confidence: 94%

The effects of histamine H2-receptor antagonists on PHA induced lymphocyte proliferation

Vickers¹,

Milliner²,

Fallowfield³

et al. 1984

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Histamine H2-receptor antagonists must be used with caution to define the pharmacology of histamine effects on lymphocyte mitogenesis induced by PHA, because they can enhance and/or suppress in their own right, because these effects are similar to those of histamine itself, because mitogenic doses of PHA can release significant amounts of histamine from supposedly pure mononuclear cell preparations.

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Effect of histamine on the mitogenic response of human lymphocytes and its modification by cimetidine and levamisole

Cited by 24 publications

References 18 publications

Antimetastatic effect of cimetidine on mice bearing a C3H mouse mammary adenocarcinoma: survival and lymphocyte function studies

Antimetastatic effect of cimetidine on mice bearing a C3H mouse mammary adenocarcinoma: survival and lymphocyte function studies

Chemiluminescence response of human blood mononuclear cells to PHA and histamine

The effects of histamine H2-receptor antagonists on PHA induced lymphocyte proliferation

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