Effect of Histamine on the Uterine Uptake of Oestradiol

Carli, D. N. De; Castro-Vázquez, Alfredo; Macome, J. C.; Rosner, Jorge M.

doi:10.1677/joe.0.0500541

Cited by 6 publications

(5 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This concept has been questioned by Finn andKeen (1962), Cecil, Bitman, and, Wrenn et al (1964), Marcus and Shelesnyak (1967), Humphrey andMartin (1968), andGarg andChaudhury (1971). Histamine, however, does appear to increase oestradiol uptake by the uterus in vivo (De Carli et al 1971) while certain antihistamine drugs enhance the antifertility effects of oestrogens administered immediately after coitus (McColl, .Robinson, and Sagritalo 1971).…”

Section: (E) Phosphatases In the Garuncles During Early Pregnancymentioning

confidence: 96%

Phosphomonoesterases and Histamine in the Uterus of the Ewe During Early Pregnancy

Murdoch¹

1972

Aust. Jnl. Of Bio. Sci.

View full text Add to dashboard Cite

An attempt was made to assess whether histamine is involved in the regulation of sheep uterine endometrial acid and alkaline phosphatases during early pregnancy. Interacting effects of progesterone and oestradiol on the endometrial enzymes and the behaviour of the phosphatases in the caruncles during early pregnancy were also examined.Histamine occurred in greater concentration in .the intercotyledonary endometrium than in the caruncles during early pregnancy and increased in both tissues between days 14 and 22. The concentration of the monoamine fell on day 31 of pregnancy and only low levels in the tissues were recorded on day 44. The subcutaneous administration of the potent histamine-releasing agent, compound 48/80, or the injection of histamine directly into the uterine lumen of ovariectomized ewes treated with combinations of progesterone and oestradiol benzoate, did not significantly alter the phosphatase activity of the endometrial tissue.Progesterone stimulated the acid and alkaline phosphatases in the intercotyledonary endometrium and maintained their activities at high levels for 21 days when administered at a dose rate of 10 mg/day. Oestradiol benzoate slightly decreased endometrial phosphatase activities when injected into ovariectomized ewes and limited the response of the enzymes to progesterone.. r Alkaline phosphatase activity in the caruncles increased between days 0 and 8 of pregnancy and fell on day 14. Only low levels of activity were found in the caruncles on days 22, 31, and 44 of pregnancy. Acid phosphatase maintained a constant level of activity in the caruncles throughout early pregnancy and was not influenced by the increase in histamine concentration between days 14 and 22.The results suggest the participation of factors other than histamine in the regulation of endometrial phosphatases during early pregnancy in the ewe. Progesterone and oestradiol may be involved to some extent but are not solely responsible for the control of the enzymes.

show abstract

Section: (E) Phosphatases In the Garuncles During Early Pregnancymentioning

confidence: 96%

Phosphomonoesterases and Histamine in the Uterus of the Ewe During Early Pregnancy

Murdoch¹

1972

Aust. Jnl. Of Bio. Sci.

View full text Add to dashboard Cite

show abstract

“…Systemically injected histamine significantly increases the uptake and retention of [3H]oestradiol by the uterus of the spayed rat De Carli et al 1971;CastroVázquez et al 1973) as well as the percentage of the hormone bound to the nuclear fraction (Rosner, Macóme, Castro-Vázquez, Brunengo, De Carli, Imas, Denari, Martínez, Pedroza & Cardinali, 1971). Moreover, histamine increases the in-vitro uptake of oestradiol by the uterus whereas it does not modify the in-vivo uptake of testosterone by this organ.…”

Section: Discussionmentioning

confidence: 99%

Further Evidence for Histamine Facilitating Oestrogen Action in the Uterus

Castro-Vázquez¹,

Gómez²,

Carli³

et al. 1976

Journal of Endocrinology

Self Cite

View full text Add to dashboard Cite

The effect of doses of estradiol ranging from 0-0125 to 1-6 mug on the uterine weight of the spayed rat was studied 24 h after a single s.c. injection of the hormone. The lowest dose inducing a significant increase in uterine weight was 0-32 mug. When histamine dihydrochloride (50 mg) was simultaneously injected with the hormone, the effect of small doses of oestradiol (0-0125--0-2 mug) was significantly increased. When oestradiol and histamine were administered for 3 successive days, the uterine weight of animals receiving 0-0125 mug oestradiol, if compared with untreated controls, was increased only in the histamine-treated group. When 0-05 mug oestradiol was administered histamine did not modify the increase already produced by the hormone. Spermidine and burimamide, two substances structurally related to histamine, increased [3H]oestradiol uptake by the spayed rat uterus. The latter (an antihistamine drug acting on H2-receptors) as well as pyrathiazine (a histamine releaser having antihistamine properties) decreased the effect of histamine on oestradiol uptake whereas diphenhydramine (an antihistamine drug blocking H1-receptors) did not modify it. Pyrathiazine was itself able to diminish oestradiol uptake.

show abstract

“…It seemed interesting to us to study the effect o f histamine on the uptake of oestradiol and testosterone. Histamine increased the uptake of labelled oestradiol by the uterus [3] and the hypothalamus ( fig. 7).…”

Section: Histaminementioning

confidence: 94%

“…The demonstration of specific receptor proteins for oestradiol binding in the rat uterus made this organ the accepted model to interpret how oestrogens act, and consequently the behaviour of other tissues was compared with the uterus [3,12].…”

Section: The Effects O F Oestradiol On the Neocortexmentioning

confidence: 99%

Oestrogen Uptake by the Central Nervous System

Rosner¹,

Denari²,

Castro-Vázquez³

et al. 1972

Gynecol Obstet Invest

View full text Add to dashboard Cite

This presentation covers three areas in relation with the mechanism of oestrogen action on the central nervous system. The ability of the uterus, vagina, anterior pituitary and anterior hypophysis to take up and retain oestradiol has been proposed as a distinctive character for the oestrogenic target organs. Although no specific protein receptors have been isolated in the neocortex, the administration of oestradiol was able to increase the incorporation of cytidine to RNA, and the protein synthesis. Those findings, together with the fact that oestradiol is concentrated and retained in the nuclei of the cerebral cortex, forced us to review the concept of target organs. The presence of very small quantities of oestradiol in the central nervous system cell nuclei may reflect the amounts that the tissue requires, and the emphasis that has always been put on quantity should be placed on there-sholds for oestrogen action in different tissues. The capacity of progestagens to compete with oestradiol binding was evaluated by organotypic culture of the hypothalamus. In a group of experiments, progestagens were added before oestradiol and, in the other group, both progestagens and oestradiol were added simultaneously to the medium. Oestradiol binding was significantly inhibited when either of the progestagens derived from 17Α-hydroxyprogesterone (chlormadinone acetate (CA) and medroxyprogesterone acetate (MPA) was added simultaneously. When added previously to oestradiol, progestagens behaved differently. MPA diminished the oestradiol binding significantly; CA, on the contrary, increased it. RO4–8347, a compound derived from retroprogesterone, diminished the oestradiol binding when added previously, but not when added simultaneously. Lynestrenol and norgestrel, both 19-norsteroids, inhibited the oestradiol binding when added simultaneously, but not when added previously. Catecholamines and oestrogens participate in the control of ovulation and it was thought worthwhile to investigate their relationships in the hypothalamus and the uterus. The simultaneous administration of epinephrine and labelled 17Β-oestradiol injected i.p. produced a significant increase in the uptake of oestradiol by the anterior hypothalamus and a diminution in the uterus. When norepinephrine and 17Β-oestradiol were simultaneously injected, the uptake of oestradiol was increased in the uterus and not modified in the hypothalamus. As the concentration of histamine is higher in the hypothalamus than in any brain region, it seemed interesting to us to study the effect of histamine on the uptake of oestradiol and testosterone. Histamine increased the uptake of labelled oestradiol by the uterus and the hypothalamus. When histamine effects were studied in relation with testosterone uptake, it increased the hypothalamic, but not the uterine uptake. Even knowing that the mammalian pineal gland has an inhibitory effect on gonadal function, little attention has been paid to the role of gonadal hormones on pineal activity. In view of the contradictory results con...

show abstract

Effect of Histamine on the Uterine Uptake of Oestradiol

Cited by 6 publications

References 0 publications

Phosphomonoesterases and Histamine in the Uterus of the Ewe During Early Pregnancy

Phosphomonoesterases and Histamine in the Uterus of the Ewe During Early Pregnancy

Further Evidence for Histamine Facilitating Oestrogen Action in the Uterus

Oestrogen Uptake by the Central Nervous System

Contact Info

Product

Resources

About