Effect of HIV-1 Infection on T-Cell–based and Skin Test Detection of Tuberculosis Infection

Rangaka, Molebogeng X; Wilkinson, Katalin A.; Seldon, Ronnett; Cutsem, Gilles van; Meintjes, Graeme; Morroni, Chelsea; Mouton, Priscilla; Diwakar, Lavanya; Connell, Tom; Maartens, Gary; Wilkinson, Robert J.

doi:10.1164/rccm.200610-1439oc

Cited by 186 publications

(181 citation statements)

References 34 publications

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“…As information was not collected with regard to the possible comorbidities present in all patients with positive or negative results, it cannot be demonstrated from these data whether comorbidity or drug treatment alone is a risk factor for ITR or that this observation was merely coincident with other factors, such as the age of the patients and sample transport conditions. However, the published evidence on T-SPOT TM .TB [9,12,14,[20][21][22] supports the conclusion that morbidity and drug treatment are not a significant cause of indeterminate results.…”

Section: Discussionmentioning

confidence: 74%

“…These tests with positive and nil internal controls are more specific than TST in diagnosing TB infection [3][4][5] and equally or more sensitive in patients with immune deficiencies. Nevertheless, indeterminate results have been reported for both tests with a frequency of 0-5.4% for the T-SPOT TM .TB test [6][7][8][9][10][11] and ,40% for the QuantiFERON1-TB Gold test [12][13][14][15][16][17]. Their occurrence seems to be associated with immunosuppression [10,18] and very young or very old age (patients aged ,5 or .80 yrs).…”

mentioning

confidence: 99%

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Indeterminate test results of T-SPOT^TM.TBperformed under routine field conditions

Beffa

Zellweger²,

Janssens³

et al. 2007

Eur Respir J

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Interferon-c release assays for the diagnosis of tuberculosis (TB) Of a total of 1,429 tests, 49 (3.4%) were indeterminate. ITRs were significantly associated with old age (.75 versus 5-75 yrs; odds ratio (OR) 7.97, 95% confidence interval (CI) 3.968-15.438) and the season during which samples were transported (autumn and winter versus spring and summer; OR 3.47, 95% CI 1.753-7.514). The incidence of ITR was 302 (2.0%) among TB contacts, 75 (1.6%) among immigrants, 156 (3.0%) in TB suspects and 32 (3.0%) among immunosuppressed patients. Sex, young age and distance to the laboratory were not associated with the rate of ITR. Of the 13 tests with ITR that were repeated, 10 gave a clear positive or negative result.Indeterminate test results with T-SPOT TM .TB under routine conditions were infrequent and more common in individuals aged .75 yrs than in children and younger adults. The incidence of indeterminate test results was low and similar among healthy tuberculosis contacts, immigrants with a positive tuberculin skin test, tuberculosis suspects and the immunosuppressed. The conditions of transportation may influence the incidence of indeterminate test results.

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Section: Discussionmentioning

confidence: 74%

mentioning

confidence: 99%

Indeterminate test results of T-SPOT^TM.TBperformed under routine field conditions

Beffa

Zellweger²,

Janssens³

et al. 2007

Eur Respir J

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“…Of these tests, the QFT-TB was first used commercially in Japan in April 2005 for the diagnosis of TB infection. Although there have been several reports investigating whether QFT-TB test and T-SPOT.TB test would be useful in immunocompromised patients [9][10][11], there has been only one report investigating the usefulness of the new test separately in individual important underlying disease [11]. Therefore, the present authors prospectively report on the results of an analysis in which the QFT-TB test was routinely performed on many consecutive immunocompromised patients separated according to individual underlying disease in several community hospitals.…”

mentioning

confidence: 99%

Clinical evaluation of QuantiFERON TB-2G test for immunocompromised patients

Kobashi

Mouri²,

Obase³

et al. 2007

Eur Respir J

109

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The usefulness of the tuberculin skin test (TST) and the QuantiFERON TB-2G (QFT-TB) test were compared in immunocompromised patients.The subjects consisted of 252 immunocompromised patients who were clinically suspected of tuberculosis (TB) infection between April 2005 and December 2006.Regarding the underlying diseases, 74 subjects had malignant diseases, 72 were undergoing immunosuppressive treatment, 52 had diabetes mellitus, 50 had chronic renal failure and four had HIV infection. While the positive rate of the QFT-TB test for the diagnosis of TB infection (TB disease or latent TB infection) was 78.1%, that of TST for TB infection was 50.0%. The QFT-TB test was significantly better than TST. However, 32 (13%) patients had an indeterminate QFT-TB result. Indeterminate findings were significantly more frequent in patients receiving immunosuppressive treatment (28%), especially with lymphocytopaenia in the peripheral blood, than in those who had other underlying diseases. While TST-positive and QFT-TB test-negative results were recognised in immunocompromised patients with bacille Calmette-Guérin vaccination or nontuberculous mycobacterial disease, TST-negative and QFT-TB test-positive results were recognised in immunocompromised patients with a past history of TB infection.It was concluded that the QuantiFERON TB-2G test is a more useful diagnostic method for tuberculosis infection than tuberculin skin test for immunocompromised patients suspected of tuberculosis disease. However, because the results of the QuantiFERON TB-2G test show an indeterminate response for patients receiving immunosuppressive treatment, especially for those with lymphocytopaenia due to severe underlying diseases, care must be taken in the interpretation of the QuantiFERON TB-2G test for these patients.

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“…Antenatal HIV prevalence is reported to be 25% of the total population wherein almost 40% have the risk of developing active TB. 32 Furthermore, 76% of TB cases are also HIV positive. 32 The team carried out a randomized controlled trial of antiretroviral therapy (ART) alone and isoniazid preventive therapy (IPT) combined with ART (cART) for prevention of HIV-associated TB.…”

Section: Tuberculosis: the Disease The Pathogen And The Hostmentioning

confidence: 99%

“…32 Furthermore, 76% of TB cases are also HIV positive. 32 The team carried out a randomized controlled trial of antiretroviral therapy (ART) alone and isoniazid preventive therapy (IPT) combined with ART (cART) for prevention of HIV-associated TB. The results indicated that isoniazid added to the anti-viral therapy reduces the risk of TB by 35% as observed after a year of IPT therapy.…”

Section: Tuberculosis: the Disease The Pathogen And The Hostmentioning

confidence: 99%

Early diagnosis and effective treatment regimens are the keys to tackle antimicrobial resistance in tuberculosis (TB): A report from Euroscicon's international TB Summit 2016

et al. 2016

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To say that tuberculosis (TB) has regained a strong foothold in the global human health and wellbeing scenario would be an understatement. Ranking alongside HIV/AIDS as the top reason for mortality due to a single infectious disease, the impact of TB extends far into socio-economic context worldwide. As global efforts led by experts and political bodies converge to mitigate the predicted outcome of growing antimicrobial resistance, the academic community of students, practitioners and researchers have mobilised to develop integrated, inter-disciplinary programmes to bring the plans of the former to fruition. Enabling this crucial requirement for unimpeded dissemination of scientific discovery was the TB Summit 2016, held in London, United Kingdom. This report critically discusses the recent breakthroughs made in diagnostics and treatment while bringing to light the major hurdles in the control of the disease as discussed in the course of the 3-day international event. Conferences and symposia such as these are the breeding grounds for successful local and global collaborations and therefore must be supported to expand the understanding and outreach of basic science research.

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Effect of HIV-1 Infection on T-Cell–based and Skin Test Detection of Tuberculosis Infection

Cited by 186 publications

References 34 publications

Indeterminate test results of T-SPOT^TM.TBperformed under routine field conditions

Indeterminate test results of T-SPOT^TM.TBperformed under routine field conditions

Clinical evaluation of QuantiFERON TB-2G test for immunocompromised patients

Early diagnosis and effective treatment regimens are the keys to tackle antimicrobial resistance in tuberculosis (TB): A report from Euroscicon's international TB Summit 2016

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Effect of HIV-1 Infection on T-Cell–based and Skin Test Detection of Tuberculosis Infection

Cited by 186 publications

References 34 publications

Indeterminate test results of T-SPOTTM.TBperformed under routine field conditions

Indeterminate test results of T-SPOTTM.TBperformed under routine field conditions

Clinical evaluation of QuantiFERON TB-2G test for immunocompromised patients

Early diagnosis and effective treatment regimens are the keys to tackle antimicrobial resistance in tuberculosis (TB): A report from Euroscicon's international TB Summit 2016

Contact Info

Product

Resources

About

Indeterminate test results of T-SPOT^TM.TBperformed under routine field conditions

Indeterminate test results of T-SPOT^TM.TBperformed under routine field conditions