Effect of hollow microneedle geometry structure on mechanical stability and microfluidic flow for transdermal drug delivery applications

Anbazhagan, Gowthami; Suseela, Sreeja Balakrishnapillai; Sankararajan, Radha

doi:10.1007/s10404-023-02636-5

Cited by 8 publications

(4 citation statements)

References 44 publications

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“…To evaluate the mechanical properties of the microneedle model, structural simulations were performed using simulation software . During microneedle puncture of the skin, the axial force dominates due to the presence of skin resistance . For structural analysis, the microneedle descended at a constant velocity of 1.1 mm s –1 and pierced the skin model.…”

Section: Resultsmentioning

confidence: 99%

“…49 During microneedle puncture of the skin, the axial force dominates due to the presence of skin resistance. 50 For structural analysis, the microneedle descended at a constant velocity of 1.1 mm s −1 and pierced the skin model. Figure 3c demonstrated the stress distribution of the microneedle during the whole insertion process, indicating that the microneedle penetrated the epidermis stably as the minimum pressure was greater than the elastic modulus of stratum corneum and epidermis (0.752 and 0.489 MPa).…”

Section: ■ Results and Discussionmentioning

confidence: 99%

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Wearable Vertical Graphene-Based Microneedle Biosensor for Real-Time Ketogenic Diet Management

Wang,

Liu,

Zhong

et al. 2024

Anal. Chem.

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Ketogenic diets have attracted substantial interest in the treatment of chronic diseases, but there are health risks with long-term regimes. Despite the advancements in diagnostic and therapeutic methods in modern medicine, there is a huge gap in personalized health management of this dietary strategy. Hence, we present a wearable microneedle biosensor for real-time ketone and glucose monitoring. The microneedle array possesses excellent mechanical properties, allowing for consistent sampling of interstitial biomarkers while reducing the pain associated with skin puncture. Vertical graphene with outstanding electrical conductivity provides the resulting sensor with a high sensitivity of 234.18 μA mM–1 cm–2 and a low limit detection of 1.21 μM. When this fully integrated biosensor was used in human volunteers, it displayed an attractive analytical capability for tracking the dynamic metabolite levels. Moreover, the results of the on-body evaluation established a significant correlation with commercial blood measurements. Overall, this cost-effective and efficient sensing platform can accelerate the application of a ketogenic diet in personal nutrition and wellness management.

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Section: Resultsmentioning

confidence: 99%

Section: ■ Results and Discussionmentioning

confidence: 99%

Wearable Vertical Graphene-Based Microneedle Biosensor for Real-Time Ketogenic Diet Management

Wang,

Liu,

Zhong

et al. 2024

Anal. Chem.

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“…Finite element analysis (FEA) software, has been used to simulate and evaluate many applications and characteristics of HMNs, such as drug delivery and diffusion into the skin [52], UV light propagation for sensing and theranostics [53], mechanical and stress analysis [24,[54][55][56], insertion [54,55], and failure [24,54,57]. Henriquez et al performed indentation simulations to find a critical application load to avoid a structural failure during microneedle insertion into human skin for stainless steel and PLGA HMNs [54], with Faraji Rad et al using simulation to investigate the deflection of HMNs and stress distribution under a lateral bending force [24].…”

Section: Introductionmentioning

confidence: 99%

“…Tamez-Tamez et al describe the use of simplified versions of microneedles (solid) and skin tissue to simulate insertion, perform stationary and linear buckling analyses, and study the impact of the tip truncation length on puncture [55]. Anbazhagan et al performed mechanical and stress analysis, with simulation performed by applying axial and bending loading on both conical and pyramidal HMNs [56]. A previous project [57] utilized simulation to investigate the clogged nozzle, deformed nozzle, and suction failure associated with the HMN design and its impact on microencapsulated cell delivery.…”

Section: Introductionmentioning

confidence: 99%

An Integrated Approach to Control the Penetration Depth of 3D-Printed Hollow Microneedles

Defelippi,

Kwong,

Appleget

et al. 2024

Applied Mechanics

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A variety of hollow microneedle (HMN) designs has emerged for minimally invasive therapies and monitoring systems. In this study, a design change limiting the indentation depth of the (3D) printed custom microneedle assembly (circular array of five conical frusta with and without a stopper, aspect ratio = 1.875) fabricated using stereolithography has been experimentally validated and modeled in silico. The micro-indentation profiles generated in confined compression on 1 mm ± 0.073 mm alginate films enabled the generation of a Prony series, where displacement ranged from 100 to 250 µm. These constants were used as intrinsic properties simulating experimental ramp/release profiles. Puncture occurred on two distinct hydrogel formulations at the design depth of 150 µm and indentation rate of 0.1 mm/s characterized by a peak force of 3.5 N (H = 31 kPa) and 8.3 N (H = 36.5 kPa), respectively. Experimental and theoretical alignments for peak force trends were obtained when the printing resolution was simulated. Higher puncture force and uniformity inferred by the stopper was confirmed via microscopy and profilometry. Meanwhile, poroviscoelasticity characterization is required to distinguish mass loss vs. redistribution post-indentation through pycnometry. Results from this paper highlight the feasibility of insertion-depth control within the epidermis thickness for the first time in solid HMN literature.

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P‐10.10: Wearable Transdermal Drug Delivery Devices based on Piezoelectric Micropumps Integrated with Microneedles Array

Sha,

Li,

Liang

et al. 2024

Symp Digest of Tech Papers

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Transdermal drug delivery refers to a drug delivery route that delivers drugs through the skin to produce local or systemic therapeutic effects. In this work, we propose a parallel valveless piezoelectric micropump integrated with hollow microneedle array, which can be used in flexible wearable transdermal drug delivery systems. The device consists of two valveless piezoelectric micropump, a hollow microneedle array and an electrical control module. The main structure of micropump and the hollow microneedle array are fabricated using 3D printing technology. The valveless piezoelectric micropump adopts a parallel dualpump structure with asynchronous drive, which achieves a full forward flow at the outlet and reduces the influence of backflow on the stability of the system. In addition, the parallel dual‐pump structure proposed in this work can be extended to a multimicropump parallel structure. We hope to fabricate small‐size micropump arrays on flexible substrates and integrate them into flexible wearable transdermal drug delivery systems.

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Effect of hollow microneedle geometry structure on mechanical stability and microfluidic flow for transdermal drug delivery applications

Cited by 8 publications

References 44 publications

Wearable Vertical Graphene-Based Microneedle Biosensor for Real-Time Ketogenic Diet Management

Wearable Vertical Graphene-Based Microneedle Biosensor for Real-Time Ketogenic Diet Management

An Integrated Approach to Control the Penetration Depth of 3D-Printed Hollow Microneedles

P‐10.10: Wearable Transdermal Drug Delivery Devices based on Piezoelectric Micropumps Integrated with Microneedles Array

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