Effect of Homocysteine Levels on Cognitive and Motor Performance in Patients with Parkinson's Disease

Gürsoy, Gizem; Yüksel, Gülbün Asuman; Çetinkaya, Yılmaz; Bayır, Buse Rahime Hasırcı; Tireli, Hülya

doi:10.5336/neuro.2018-60616

Cited by 1 publication

(1 citation statement)

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“…A common cause of disability in the elderly population, Parkinson's disease is a movement disorder that is characterized by tremor, rigidity, akinesia, and loss of postural reflexes, and causes immobility and frequent falls [9]. Considering the relationship between the diet and Parkinson's disease with a multifactorial etiology comprising genetic and environmental factors, it was found that a Mediterranean diet, caffeine, and the vitamins B6 and E were associated with a lower risk of developing Parkinson's disease (PD) while hyperhomocysteinemia deteriorated the prognosis of the disease owing to its neurotoxic effect, but did not increase the risk of developing the disease [10,11].…”

Section: Discussionmentioning

confidence: 99%

Effects of vitamin D on motor symptoms and cognitive functions in people with Parkinson’s disease

Yüksel¹,

Gürsoy²

2021

GSC Biol. and Pharm. Sci.

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Aim of the study: Parkinson’s disease is the second most common neurodegenerative disorder. The present study investigates the role of vitamin D deficiency thought to be one of the etiopathological and modifying factors in Parkinson’s disease that is known to be multifactorial. Materials and Methods: Designed as a retrospective review of medical records, this study compares the serum vitamin D levels of the idiopathic Parkinson’s disease patients with and without dementia to those of the healthy individuals with no metabolic/degenerative disorders. It also investigates the relationship between the patients’ Standardized Mini-Mental State Examination (SMMSE) and the Unified Parkinson’s Disease Rating Scale (UPDRS) scores and serum vitamin D levels to show the effects of vitamin D on motor symptoms and cognitive functions. Results: In this study, we compared the serum vitamin D levels of 40 Parkinson’s disease patients and 15 Parkinson’s disease patients with dementia to those of the control group comprising 30 healthy individuals. Vitamin D levels were 21,4±15,9 ng/mL in the control group; 16,5±6,4 ng/mL in Parkinson’s disease patients and 13,8±4,5 ng/mL in Parkinson’s disease patients with dementia. All the patient groups had significantly lower vitamin D levels than the control group (p<0,005). Within the Parkinson’s disease group, furthermore, the dementia group had lower vitamin D levels than the non-dementia group. Having examined the relationship between the SMMSE scores and serum vitamin D levels, we found a significant difference in the Parkinson’s disease dementia group (p: 0,020), as well as a relationship of 59,4% in the same direction. On the other hand, there was no significant difference in either patient group in the scores of UPDRS evaluating clinical disability. Conclusion: Consistent with the literature, the present study found that people with Parkinson’s disease had lower mean values of serum vitamin D levels than the control group and showed that serum vitamin D levels were correlated with the cognitive performance. However, the study could not find a relationship between the serum vitamin D levels and the motor performance.

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Section: Discussionmentioning

confidence: 99%