Effect of homogenization methods on the physical stability of nutrition grade nanoliposomes used for encapsulating high oleic palm oil

Beltrán, Juan David; Ricaurte, Leidy; Estrada, Katherine Bauer; Quintanilla-Carvajal, María Ximena

doi:10.1016/j.lwt.2019.108801

Cited by 24 publications

(9 citation statements)

References 29 publications

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“…Therefore, all capsules (Table 1) can be called white shrimp peptide nanoliposomes. Besides, the nanometric size presented by white shrimp liposomes can offer all the benefits of nanocarriers for applications in the food industry, such as a high transfer surface (mass and heat) and greater diffusion potential (Beltrán et al, 2020).…”

Section: Particle Size and Pdimentioning

confidence: 99%

“…Liposome stability is an important parameter in the process of encapsulation by liposomes, since the viability of using an encapsulation system in manufacturing, such as in the food industry, depends on it (Beltrán et al, 2020). This parameter is useful to predict the stability of colloidal suspensions, and its value corresponds to the difference in electrical potential between the nanoparticles and the liquid medium where they are dispersed.…”

Section: Liposome Stabilitymentioning

confidence: 99%

“…Liposomes are encapsulation systems with high biocompatibility and biodegradability, consisting of one or more lipid bilayers, which involve an aqueous phase called a nucleus, within a lipid membrane, which can be used for the encapsulation of hydrophobic, hydrophilic, and amphiphilic compounds (Beltrán et al, 2020;da Rosa Zavareze et al, 2014).…”

mentioning

confidence: 99%

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Nanoencapsulation of white shrimp peptides in liposomes: Characterization, stability, and influence on bioactive properties

Latorres

Aquino

Rocha

et al. 2021

J. Food Process. Preserv.

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Bioactive peptides are low-molecular-weight protein fractions with amino acid sequences that can promote various biological activities. These are compounds typically obtained through the cleavage of peptide bonds via enzymatic hydrolysis, fermentative processes, or food processing (Liu et al., 2020). Besides high biological activity, these compounds have stable structures, which allow the digestive epithelial barrier to cross and reach blood vessels (Shabestarian et al., 2016).Among the physiological activities presented by such peptide compounds, anti-hypertensive and antioxidant bioactivity stand

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Section: Particle Size and Pdimentioning

confidence: 99%

Section: Liposome Stabilitymentioning

confidence: 99%

See 1 more Smart Citation

Nanoencapsulation of white shrimp peptides in liposomes: Characterization, stability, and influence on bioactive properties

Latorres

Aquino

Rocha

et al. 2021

J. Food Process. Preserv.

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“…The selection of the nanoencapsulation method depends on the specific oil being encapsulated and the material used as the encapsulant [18,19]. Additionally, studies have been conducted to develop nano-emulsions containing HCPO for use in packaging, and the physical, thermal, and thermodynamic properties of nanoemulsions have been evaluated [20][21][22][23][24].…”

Section: Introductionmentioning

confidence: 99%

Optimization and Characterization of Interspecific Hybrid Crude Palm Oil Unaué HIE OxG Nanoparticles with Vegetable By-Products as Encapsulants

Assunção,

Oliveira de Souza,

Shahidi

et al. 2024

Foods

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Interspecific hybrid crude palm oil (HCPO) HIE OxG derived from crossbred African oil palm (Elaeis guineensis) and American Caiaué (Elaeis oleifera) is prominent for its fatty acid and antioxidant compositions (carotenoids, tocopherols, and tocotrienols), lower production cost, and high pest resistance properties compared to crude palm oil. Biodegradable and sustainable encapsulants derived from vegetable byproducts were used to formulate HCPO nanoparticles. Nanoparticles with hybrid crude palm oil and jackfruit seed flour as a wall material (N-JSF) and with hybrid crude palm oil and jackfruit axis flour as a wall material (N-JAF) were optimized using a 22 experimental design. They exhibited nanoscale diameters (<250 nm) and were characterized based on their zeta potential, apparent viscosity, pH, color, and total carotenoid content. The nanoparticles demonstrated a monodisperse distribution, good uniformity, and stability (polydispersity index < 0.25; zeta potentials: N-JSF −19.50 ± 1.47 mV and N-JAF −12.50 ± 0.17 mV), as well as high encapsulation efficiency (%) (N-JSF 86.44 ± 0.01 and N-JAF 90.43 ± 1.34) and an optimal carotenoid retention (>85%). These nanoparticles show potential for use as sustainable and clean-label HCPO alternatives in the food industry.

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“…High shear homogenization is a proven liposome manufacturing technique for small to large scale production in a sterile setting with GMP compliance [ 30 , 31 ]. Homogenization speed and mixing time are critical process parameters and need to be optimized [ 32 ].…”

Section: Introductionmentioning

confidence: 99%

Development of Adenovirus Containing Liposomes Produced by Extrusion vs. Homogenization: A Comparison for Scale-Up Purposes

et al. 2022

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Adenovirus (Ad) is a widely studied viral vector for cancer therapy as it can be engineered to cause selective lysis of cancer cells. However, Ad delivery is limited in treating cancers that do not have coxsackievirus and adenovirus receptors (CAR). To overcome this challenge, Ad-encapsulated liposomes were developed that enhance the delivery of Ads and increase therapeutic efficacy. Cationic empty liposomes were manufactured first, to which an anionic Ad were added, which resulted in encapsulated Ad liposomes through charge interaction. Optimization of the liposome formula was carried out with series of formulation variables experiments using an extrusion process, which is ideal for laboratory-scale small batches. Later, the optimized formulation was manufactured with a homogenization technique—A high shear rotor-stator blending, that is ideal for large-scale manufacturing and is in compliance with Good Manufacturing Practices (GMP). Comparative in vitro transduction, physicochemical characterization, long-term storage stability at different temperature conditions, and in vivo animal studies were performed. Ad encapsulated liposomes transduced CAR deficient cells 100-fold more efficiently than the unencapsulated Ad (p ≤ 0.0001) in vitro, and 4-fold higher in tumors injected in nude mice in vivo. Both extrusion and homogenization performed similarly–with equivalent in vitro and in vivo transduction efficiencies, physicochemical characterization, and long-term storage stability. Thus, two Ad encapsulated liposomes preparation methods used herein, i.e., extrusion vs. homogenization were equivalent in terms of enhanced Ad performance and long-term storage stability; this will, hopefully, facilitate translation to the clinic.

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Effect of homogenization methods on the physical stability of nutrition grade nanoliposomes used for encapsulating high oleic palm oil

Cited by 24 publications

References 29 publications

Nanoencapsulation of white shrimp peptides in liposomes: Characterization, stability, and influence on bioactive properties

Nanoencapsulation of white shrimp peptides in liposomes: Characterization, stability, and influence on bioactive properties

Optimization and Characterization of Interspecific Hybrid Crude Palm Oil Unaué HIE OxG Nanoparticles with Vegetable By-Products as Encapsulants

Development of Adenovirus Containing Liposomes Produced by Extrusion vs. Homogenization: A Comparison for Scale-Up Purposes

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