Effect of honey on nocturnal cough and sleep quality: a double-blind, randomized, placebo-controlled study

Ha, Cohen; Rozen, J; Krista, H; Laks, Yoseph; Berkovitch, Matitiahu; Uziel, Yosef; Kozer, Eran; Pomeranz, Avishalom; Efrat, Haim

doi:10.1007/s12456-012-0042-2

Cited by 4 publications

(6 citation statements)

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“…Patients will not purchase or believe in a medicine that they know has no active component or which is referred to as a placebo, and regulatory authorities will not allow claims for cough medicines composed only of flavoring and excipients. However, with publicity around clinical trials testing honey as a cough medicine [14][15][16] and negative reports about conventional antitussives such as dextromethorphan [17,18], the public has become more convinced about the efficacy of simple linctus medicines containing honey and glycerol and these simple linctuses are now marketed with honey, glycerol, and sugar declared as active ingredient [19]. The great advantage of this type of medicine is that they are supported by pediatricians as safe for children and they can be dosed frequently without any major risk of side effects.…”

Section: What Makes a Good Placebo Cough Medicine?mentioning

confidence: 99%

The Powerful Placebo Effect in Cough: Relevance to Treatment and Clinical Trials

Eccles

2019

Lung

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Interest in the placebo effect of medicines has developed from the use of placebo treatments as controls in clinical trials into a whole new area of research around how placebos fit into a psychosocial model of therapeutics. The large placebo effect associated with cough medicines is both a problem and an opportunity for researchers: a problem for clinical trials on new actives as the active must beat the large placebo effect, and an opportunity for harnessing the placebo effect to produce effective cough medicines without any pharmacologically active ingredient. This review discusses the mechanisms associated with the placebo effect of cough medicines and distinguishes between a 'perceived placebo effect' and a true 'placebo effect'. The efficacy of sweeteners in cough syrups is discussed as well as viscosity, mucoadhesion, and flavoring. The complexity of modern cough medicines is demonstrated by an example of a medicine which contains one active ingredient, and eighteen excipients which provide a complex and intense sensory experience to enhance the placebo effect and complement the pharmacological activity of the medicine.

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Section: What Makes a Good Placebo Cough Medicine?mentioning

confidence: 99%

The Powerful Placebo Effect in Cough: Relevance to Treatment and Clinical Trials

Eccles

2019

Lung

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“…Five RCTs have shown that administering 2.5 to 10 ml of oral honey before bed can improve nocturnal cough and parental sleep in children with acute upper respiratory tract infections compared with no treatment or placebo. [29][30][31][32][33][34] Two trials found that honey was better than diphenhydramine at improving cough symptoms. 30,31 One trial showed that honey was more effective at improving nocturnal cough symptoms than dextromethorphan, while another demonstrated no difference between dextromethorphan and honeytreated groups, with an overall nonsignificant difference by meta-analysis.…”

Section: Head and Neck Surgerymentioning

confidence: 99%

“…34 Two studies comparing different types of honey showed no difference in symptom reduction by honey type. 29,31 One RCT showed that a polysaccharide-resin-honey cough syrup was more effective and faster at reducing cough symptoms than carbocysteine cough syrup. 35 Three studies reported adverse effects including gastrointestinal upset, nervousness, and sleep disturbance.…”

Section: Head and Neck Surgerymentioning

confidence: 99%

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Honey as a Treatment in Otorhinolaryngology: A Review by Subspecialty

Tharakan

Bent

Tavaluc

2018

Ann Otol Rhinol Laryngol

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Objectives: To provide an up-to-date review of honey’s effectiveness and potential applications in otorhinolaryngology. Methods: A literature search of the online databases PubMed, EMBASE, and Cochrane Central Register of Controlled Trials was conducted. Results: Sixty-three studies were identified within head and neck surgery (n = 23, 36%); pediatric otolaryngology (n = 18, 29%); rhinology, sinus, and skull base surgery (n = 11, 17%); otology (n = 6, 10%), facial plastic and reconstructive surgery (n = 3, 5%); and laryngology (n = 2, 3%). Studies included 6 meta-analyses, 44 randomized control trials, 5 case reports, and 8 animal models or in vitro studies. Of 55 clinical studies, 50 reported Level 1 evidence (prospective randomized control trials), and 5 reported Level 4 evidence (case series). The evidence level by subspecialty was: head and neck surgery (Level 1 n = 23), pediatrics (Level 1 n = 18), rhinology (Level 1 n = 7, level 4 n = 1), otology (Level 1 n = 1, Level 4 n = 3), facial plastics and reconstructive surgery (Level 4 n = 1), and laryngology (Level 1 n = 2). Conclusions: Honey can be used for a variety of otolaryngology conditions. The highest quality meta-analyses support oral honey for prevention and treatment of oral mucositis in cancer patients, cough associated with upper respiratory infection in children, and pain control after tonsillectomy. Further research will likely justify broader applications.

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“…16 In addition, different antioxidant compounds such as vitamin C, flavonoids, monophenolics, and polyphenolics are present in honey that may be responsible for its beneficial respiratory effects. 17,18 Hyssopus officinalis L Flowering parts of Hyssopus officinalis have been used in the formulation of laūqs for the treatment of several respiratory diseases such as chronic cough, asthma, swelling of the lungs, and catarrh. 8 Methanolic extract of H officinalis exhibited potent antioxidant activities.…”

Section: Mechanisms Of Actionmentioning

confidence: 99%

Laūq

Karegar-Borzi

Salehi

Rahimi

2015

J Evid Based Complementary Altern Med

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Laūq is a pharmaceutical dosage form that had been mainly used for the treatment of various respiratory disorders in traditional Persian medicine. It is important from 2 aspects: a dosage form with efficient and optimum delivery of drugs to the respiratory tract and biological effects of its ingredients. Natural medicine in laūq has been demonstrated to act in respiratory disorders by their antitussive, antiallergic, anti-inflammatory, antioxidant, spasmolytic, and antibacterial activities. Some of these natural remedies act by most of the mentioned mechanisms such as Cydonia oblonga, Glycyrrhiza glabra, Crocus sativus, Hyssopus officinalis, Foeniculum vulgare, and honey. However, the evidence is limited including Cassia fistula, Papaver somniferum, and Drimia maritima. According to positive pharmacokinetic and pharmacodynamic aspects of laūqs, they may be considered as efficient dosage forms for delivery of drugs to the respiratory tract. For better compatibility of patients, it could be substituted laūqs with newer drug delivery systems like lozenges.

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Effect of honey on nocturnal cough and sleep quality: a double-blind, randomized, placebo-controlled study

Cited by 4 publications

References 0 publications

The Powerful Placebo Effect in Cough: Relevance to Treatment and Clinical Trials

The Powerful Placebo Effect in Cough: Relevance to Treatment and Clinical Trials

Honey as a Treatment in Otorhinolaryngology: A Review by Subspecialty

Laūq

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