Effect of honey on oxidation, chlorination and nitration by purified equine myeloperoxidase

Saad, Aissat; Benbarek, H.; Franck, Thierry; Kohnen, Stephan; Serteyn, Didier; Mustafa, Ahmed M.; Mouithys‐Mickalad, Ange

doi:10.12980/jclm.5.2017j7-84

Cited by 3 publications

(1 citation statement)

References 39 publications

(41 reference statements)

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“…The150-kDa MPO protein is a cationic homodimer consisting of two 15-kDa light chains and two variable-weight glycosylated heavy chains linked to a prosthetic heme group. 30,31 The light chains are glycosylated and contained the modified iron protoporphyrin IX in active site. In addition, the light and heavy chains form two identical 73-kDa monomers linked by a cystine bridge at Cys153.…”

Section: Molecular Docking Studymentioning

confidence: 99%

Hepatoprotective Effects of Kombucha Tea in Carbon Tetrachloride-Induced Hepatotoxicity: An In Vivo and Molecular Docking Studies

2021

TJNPR

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Globally, liver diseases were estimated to cause around two million deaths per year due to viral hepatitis, hepatocellullar carcinoma, and cirrhosis. 1 In Egypt, the liver disease incidence increased mainly due to bilharziasis, viral infection with hepatitis C, and hepatocellullar carcinoma which causes progressive liver damage. 2 Due to COVID-19 pandemic, there was a difficulty of transportation between the world states, 3 and a lot of need to manufacture effective and safe natural products locally. 4 This led to search for a beneficial product having antioxidant and hepatoprotective effects like Kombucha. 5 Worldwide, Kombucha is a traditional fermented tea beverage resulting from the essential process which is the fermentation of tea by mushroom known as "tea fungus" or "Manchurian tea". 6 It is widely spread from China to Russia and to the rest of the world. Recently, kombucha is a valuable product and powerful beverage which exerts beneficial effects on human health as antioxidant, antdiabetic, 7 hepatoprotective, 8 anticancer, 9 antimicrobial, 10 due to the release of many bioactive compounds resulting from fermentation process. Various biological effects of black and green tea extracts have been related to

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Section: Molecular Docking Studymentioning

confidence: 99%

Hepatoprotective Effects of Kombucha Tea in Carbon Tetrachloride-Induced Hepatotoxicity: An In Vivo and Molecular Docking Studies

2021

TJNPR

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Dual cross-linked honey coupled 3D antimicrobial alginate hydrogels for cutaneous wound healing

Mukhopadhyay

Rajput

Barui

et al. 2020

Materials Science and Engineering: C

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Inhibitory effect of organic acids on human neutrophil myeloperoxidase’s peroxidation, chlorination, and nitration activities

Sarkaratı

2023

Turkish Journal of Biochemistry

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Objectives Myeloperoxidase from polymorphonuclear leukocytes is an important enzyme in oxidative metabolism and has a key role in tissue injuries in oxidative stress and inflammatory conditions. Therefore, its inhibitors have become the focus of studies on new drug development in recent years. The aim of the study was to determine the inhibitory effect of organic acids on the peroxidation, chlorination, and nitration activities of myeloperoxidase. Methods Seven organic acids naturally abundant in plants were tested. Different activities of myeloperoxidase were measured in the presence of various amounts of organic acids, and inhibition rates and kinetic parameters were determined for each organic acid separately. Results All the organic acids examined had inhibitory effects on the different activities of myeloperoxidase. Comparison of the IC50 values obtained for peroxidation, chlorination, and nitration activities showed that oxalic acid was the strongest inhibitor of myeloperoxidase activity, while citric acid and succinic acid were the weakest. Conclusions The results suggested that all the organic acids examined are inhibitors of myeloperoxidase. In particular, oxalic acid and fumaric acid are popular candidates for drug development research. More studies are needed to determine the in vivo effects of organic acids and their effects in the treatment of disease.

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Effect of honey on oxidation, chlorination and nitration by purified equine myeloperoxidase

Cited by 3 publications

References 39 publications

Hepatoprotective Effects of Kombucha Tea in Carbon Tetrachloride-Induced Hepatotoxicity: An In Vivo and Molecular Docking Studies

Hepatoprotective Effects of Kombucha Tea in Carbon Tetrachloride-Induced Hepatotoxicity: An In Vivo and Molecular Docking Studies

Dual cross-linked honey coupled 3D antimicrobial alginate hydrogels for cutaneous wound healing

Inhibitory effect of organic acids on human neutrophil myeloperoxidase’s peroxidation, chlorination, and nitration activities

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