Effect of Honey versus Sucrose on Appetite, Appetite-Regulating Hormones, and Postmeal Thermogenesis

Larson‐Meyer, D. Enette; Willis, Kentz S.; Willis, Lindsey M.; Austin, Kathy J.; Hart, Ann Marie; Breton, Ashley B.; Alexander, Brenda M.

doi:10.1080/07315724.2010.10719885

Cited by 29 publications

(27 citation statements)

References 42 publications

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“…Furthermore, honey consumption may alter the meal-induced response of ghrelin (hunger hormone) and anorexigenic hormone, peptide tyrosine-tyrosine 3-36 (PYY 3-36 ). [20]…”

Section: Discussionmentioning

confidence: 99%

The Antinociceptive Effects of Tualang Honey in Male Sprague-Dawley Rats: A Preliminary Study

Aziz

Ismail

Hussin

et al. 2014

Journal of Traditional and Complementary Medicine

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Tualang honey (蜂蜜 Fēng Mì) is known to have anti-inflammatory property, but its antinociceptive property has not been extensively investigated. In this study, we examined the preemptive effects on administering different doses of Tualang honey and prednisolone on the nociceptive response in male Sprague-Dawley rats. Thirty-five male Sprague-Dawley rats were randomized into five groups (n = 7) and each group received either distilled water, Tualang honey (0.2, 1.2 or 2.4 g/kg) or prednisolone (10 mg/kg) for 10 days. The response to noxious thermal stimulus was assessed using tail flick test on Day 10. The well-being of the rats was also assessed by monitoring their food intake and body weight. Data were analyzed using one-way Analysis of Variance (ANOVA) with post-hoc Scheffe's test and P value less than 0.05 was considered significant. In tail flick test, the tail flick latency time was significantly higher in the groups that received 1.2 g/kg and 2.4 g/kg of Tualang honey and 10 mg/kg of prednisolone, compared to the control group (P < 0.05). There was significant reduction in the total food pellet intake in the groups receiving prednisolone and Tualang honey (1.2 g/kg and 2.4 g/kg) compared to controls; however, the body weight gain was only significantly reduced in the prednisolone group. All the parameters were not significantly affected in the group receiving 0.2 g/kg of Tualang honey. In conclusion, preemptive administration of Tualang honey (1.2 g/kg and 2.4 g/kg) and prednisolone (10 mg/kg) had reduced the pain responses. The reduced weight gain in the prednisolone group is an unwanted effect due to its metabolic and central actions. Further studies are required to confirm the antinociceptive effects and elucidate the mechanism of antinociceptive action of Tualang honey in the rats.

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“…Furthermore, honey consumption may alter the meal-induced response of ghrelin (hunger hormone) and anorexigenic hormone, peptide tyrosine-tyrosine 3-36 (PYY 3-36 ). [20]…”

Section: Discussionmentioning

confidence: 99%

The Antinociceptive Effects of Tualang Honey in Male Sprague-Dawley Rats: A Preliminary Study

Aziz

Ismail

Hussin

et al. 2014

Journal of Traditional and Complementary Medicine

View full text Add to dashboard Cite

show abstract

“…The first 3 cc at each time point draw was presumed to be diluted with saline and was discarded. Resting energy expenditure (REE) and respiratory quotient (RQ) were measured using a metabolic cart (160 lpm pneumatach, ParvoMedics, TrueOne 2400, Sandy, UT, USA) while the subject lay motionless in the supine position, as previously described [31]. The last 20 min of data was used to calculate REE.…”

Section: Methodsmentioning

confidence: 99%

Influence of Running and Walking on Hormonal Regulators of Appetite in Women

et al. 2012

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Nine female runners and ten walkers completed a 60 min moderate-intensity (70% VO2max) run or walk, or 60 min rest in counterbalanced order. Plasma concentrations of the orexogenic peptide ghrelin, anorexogenic peptides peptide YY (PYY), glucagon-like peptide-1 (GLP-1), and appetite ratings were measured at 30 min interval for 120 min, followed by a free-choice meal. Both orexogenic and anorexogenic peptides were elevated after running, but no changes were observed after walking. Relative energy intake (adjusted for cost of exercise/rest) was negative in the meal following running (−194 ± 206 kcal) versus walking (41 ± 196 kcal) (P = 0.015), although both were suppressed (P < 0.05) compared to rest (299 ± 308 and 284 ± 121 kcal, resp.). The average rate of change in PYY and GLP-1 over time predicted appetite in runners, but only the change in GLP-1 predicted hunger (P = 0.05) in walkers. Results provide evidence that exercise-induced alterations in appetite are likely driven by complex changes in appetite-regulating hormones rather than change in a single gut peptide.

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“…In rats, a recent study reported that the levels of leptin were considerably lower in rats administered honey than in those fed sucrose 119. Similarly, compared with sucrose-containing diet, honey was reported to delay postprandial ghrelin release and enhance total peptide YY response in healthy human subjects 148. Even though the data are still limited, fructose in honey may contribute to the modulating effect of honey on appetite-regulating hormones 35, 149.…”

Section: Effect Of Honey On Appetite-regulating Hormones Body Weightmentioning

confidence: 99%

“…Although the mechanisms by which honey decreases weight gain are still not fully understood, findings from some recent studies suggest that honey might reduce weight gain via modulation of appetite-regulating hormones such as leptin, ghrelin and peptide YY 119, 148. Furthermore, based on findings which showed lack of significant difference in food efficiency ratio (FER) in sucrose- and honey-fed rats, reduced food intake might contribute considerably to reduced weight gain in honey-fed rats 119.…”

Section: Effect Of Honey On Appetite-regulating Hormones Body Weightmentioning

confidence: 99%

Honey - A Novel Antidiabetic Agent

Erejuwa

Sulaiman²,

Wahab³

2012

Int. J. Biol. Sci.

128

120

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Diabetes mellitus remains a burden worldwide in spite of the availability of numerous antidiabetic drugs. Honey is a natural substance produced by bees from nectar. Several evidence-based health benefits have been ascribed to honey in the recent years. In this review article, we highlight findings which demonstrate the beneficial or potential effects of honey in the gastrointestinal tract (GIT), on the gut microbiota, in the liver, in the pancreas and how these effects could improve glycemic control and metabolic derangements. In healthy subjects or patients with impaired glucose tolerance or diabetes mellitus, various studies revealed that honey reduced blood glucose or was more tolerable than most common sugars or sweeteners. Pre-clinical studies provided more convincing evidence in support of honey as a potential antidiabetic agent than clinical studies did. The not-too-impressive clinical data could mainly be attributed to poor study designs or due to the fact that the clinical studies were preliminary. Based on the key constituents of honey, the possible mechanisms of action of antidiabetic effect of honey are proposed. The paper also highlights the potential impacts and future perspectives on the use of honey as an antidiabetic agent. It makes recommendations for further clinical studies on the potential antidiabetic effect of honey. This review provides insight on the potential use of honey, especially as a complementary agent, in the management of diabetes mellitus. Hence, it is very important to have well-designed, randomized controlled clinical trials that investigate the reproducibility (or otherwise) of these experimental data in diabetic human subjects.

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Effect of Honey versus Sucrose on Appetite, Appetite-Regulating Hormones, and Postmeal Thermogenesis

Cited by 29 publications

References 42 publications

The Antinociceptive Effects of Tualang Honey in Male Sprague-Dawley Rats: A Preliminary Study

The Antinociceptive Effects of Tualang Honey in Male Sprague-Dawley Rats: A Preliminary Study

Influence of Running and Walking on Hormonal Regulators of Appetite in Women

Honey - A Novel Antidiabetic Agent

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