Studies have shown that the prevalence of MS disease has an ascending trend. These patients due to the illness have a poor self-image and life expectancy. Accordingly, this study was conducted to determine the effectiveness of positive thinking skills on Life expectancy and self-concept in patients with multiple sclerosis. The research method was experimental and was a pretestposttest design with a control group. The study sample was composed of 30 female patients with multiple sclerosis under the MS Society in Tehran. In a preliminary study, thay had gained a weak score in the Miller's life expectancy (1988) and Beck's self concept questionnaire (1990). The samples, by using simple random sampling method, were divided into two experimental and control groups each of 15 participants. The experimental group, at 8 sessions for 90 minutes (2 sessions per week), received training on positive thinking skills and the control group did not receive any education and treatment. One week after the training session, a Post-test was performed in both groups concurrently, but separately. The results of analysis of covariance showed that positive thinking skills training is effective on enhancement of self-concept and life expectancy in the experimental group (p<0.05). Conclusion: According to the results of this method it can be used to increase selfperception and life expectancy (p<0/05).