Effect of HTL0045725, a selective agonist of the orphan receptor GPR52, on kinase and transcription factor phosphorylation in striatal neurons

The Identification of GPR52 Agonist HTL0041178, a Potential Therapy for Schizophrenia and Related Psychiatric Disorders

“…However, these changes led to significant efflux and higher Cli in 17 such that the compound offered no improvement over 1 . However, the high potency and LLE , of compound 17 has led to a 3 H-labeled version of this compound finding utility as a radioligand and pharmacological tool (aka HTL0045725 ).…”