Effect of Human Adenovirus Type 35 Concentration on Its Inactivation and Sorption on Titanium Dioxide Nanoparticles

Syngouna, Vasiliki I.; Georgopoulou, Maria P.; Bellou, Maria I.; Vantarakis, Apostolos

doi:10.1007/s12560-023-09582-z

Cited by 1 publication

(2 citation statements)

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“…TiO 2 NPs in the dark or under daylight could decrease influenza titres and degrade this RNA virus's envelope [48]. Anastase TiO 2 NPs were also reported to reduce human adenovirus, a non-enveloped DNA virus, under dark and ambient light via sorption and inactivation [49]. Nanostructured TiO 2 thin films composed of anatase, rutile crystallites, and carbon were recently reported to exhibit antimicrobial activity against a range of pathogens, such as E. coli, S. aureus, P. aeruginosa, and S. cerevisiae, without UV activation, although with the UV photocatalyst, the TiO 2 thin film was more efficient by an order close to one log [50].…”

Section: Discussionmentioning

confidence: 99%

“…However, the extraction process did not allow us to differentiate some of these mechanisms, including photocatalytic degradation and adsorption, when the lysis is incomplete, for instance, owing to aggregation. A detailed understanding of the virus removal mechanism by TiO 2 NPs could be important for the development of potential applications [49].…”

Section: Discussionmentioning

confidence: 99%

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Impact of Nanoparticle-Based TiO2 Surfaces on Norovirus Capsids and Genome Integrity

Raymond,

St-Germain,

Paul

et al. 2024

Foods

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Human noroviruses (HuNoVs) are among the main causes of acute gastroenteritis worldwide. HuNoVs can survive for several days up to weeks at room temperature in the environment, on food, and on food handling and processing surfaces. As a result, this could lead to viral spread through the ingestion of food in contact with contaminated surfaces. The development of stable surface materials with antiviral activity might be useful to reduce viral outbreaks. Metal-based compounds, including photoactivated titanium nanoparticles (TiO2 NPs), are known for their antiviral activity. In this study, we tested the impact of 2000 µg/mL TiO2 NPs, with or without UV activation, on HuNoV GII and murine norovirus. Their recovery rates were reduced by 99.6%. We also evaluated a new TiO2 NP-coating process on a polystyrene surface. This process provided a homogenous coated surface with TiO2 NPs ranging between 5 nm and 15 nm. Without photoactivation, this TiO2 NP-coated polystyrene surface reduced the recovery rates of intact HuNoV GII by more than 94%. When a capsid integrity treatment with PtCl4 or a longer reverse transcription polymerase chain detection approach was used to evaluate virus integrity following contact with the TiO2 NP-coated polystyrene, the HuNoV GII recovery yield reduction varied between 97 and 100%. These results support the hypothesis that TiO2 NP-coated surfaces have the potential to prevent viral transmission associated with contaminated food surfaces.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%