Effect of Human Chorionic Gonadotropin Injection Before Frozen Embryo Transfer on Pregnancy Outcomes in Endometriosis-Associated Infertility

Du, Yanbo; Yan, Lei; Sun, Minmin; Yan, Sheng; Li, Xiufang; Feng, Zhenhua; Tang, Rong

doi:10.3389/fmed.2020.592921

Cited by 10 publications

(9 citation statements)

References 30 publications

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“…It was speculated that hCG might enhance embryo implantation by interacting with molecules regulating endometrial receptivity. [26] In the present study, we found a significant increase in the pregnancy rate. However, the difference of live birth rate was not statistically significant, which may be related to the limit of designate time of our study, that some patients did not give birth at the end of study, which led to a relative increase in the live birth rate that was not statistically significant.…”

Section: Discussionsupporting

confidence: 62%

Effect of human chorionic gonadotropin injection before frozen-thawed embryo transfer: A retrospective cohort study

Xin,

Dong,

Guan

et al. 2023

Medicine

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The aim of this study is to investigate the effect of human chorionic gonadotropin (hCG) in hormone replacement regimen for frozen-thawed embryos. We performed a retrospective cohort study and included patients who underwent frozen embryo transfer (FET) between January 1, 2020 and May 31, 2022. According to the protocols for the FET cycle, the patients were divided into control (n = 238) and hCG groups (n = 216). The clinical pregnancy rate, live birth rate, early abortion rate, late abortion rate, and ectopic pregnancy rate were compared between the 2 groups. There was a significant difference in clinical pregnancy rate between the hCG and control groups (55.1% vs 45.8%, P = .048). The ectopic pregnancy rate decreased (5.0% vs 6.4%, P = .654), while the live birth rate increased (36.1% vs 29.0%, P = .105) in the hCG group. However, these differences were not statistically significant. The administration of hCG injection in HRT-FET cycles alone was also found to be associated with clinical pregnancy by logistic regressive analysis. HCG injection in the hormone replacement regimen for FET increased the clinical pregnancy rate.

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Section: Discussionsupporting

confidence: 62%

Effect of human chorionic gonadotropin injection before frozen-thawed embryo transfer: A retrospective cohort study

Xin,

Dong,

Guan

et al. 2023

Medicine

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“…When E2 is <2724.8 pg/mL, within the range 2724.8–4087.2 pg/mL, and >4087.2 pg/mL on trigger day, the live birth rates were 28.80%, 26.90% and 25.99%, respectively 12 . We noted that live birth rates reported in Duan et al's study were lower than those in the present study (45.4%) and other studies (which were within the range 35.6%–45.6% 19–22 ). Therefore, other factors, except for E2 on trigger day, might interfere with the live birth rates for FET cycles in Duan et al's 12 study.…”

Section: Discussioncontrasting

confidence: 57%

Estradiol on trigger day: Irrelevant to live birth rates of fresh cycles but positively associated with cumulative live birth rates

Wang,

Jin,

Shi

et al. 2023

Intl J Gynecology & Obste

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ObjectiveTo assess the effects of estradiol (E2) on trigger day on cumulative live birth rates (CLBRs), and pregnancy outcomes after fresh and frozen–thawed embryo transfer (FET).MethodsThis multicenter retrospective cohort study included 42 315 patients from five reproductive centers. Six subgroups were divided according to E2 on trigger day (<1000, 1000–2000, 2000–3000, 3000–4000, 4000–5000, >5000 pg/mL). Smooth curve fitting and nonlinear mixed‐effects models were used.ResultsWhen E2 was <5500 pg/mL, the CLBR increased by 10% for every 1000 pg/mL increase in E2. When E2 was between 5500 and 13 281 pg/mL, CLBR increased by 1.8% for every 1000 pg/mL increase in E2. When E2 was >13 281 pg/mL, CLBR decreased by 3% for every 1000 pg/mL increase in E2. From group E2 < 1000 to group E2 > 5000 pg/mL, pregnancy and live birth rates in fresh cycles were not related to E2. The live birth rate after FET was higher in the E2 ≥ 5000 pg/mL group than in the E2 < 1000 pg/mL group (odds ratio [OR] 4.03, and 95% confidence interval [CI] 3.74–4.35; adjusted OR 1.20, 95% CI 1.05–1.37).ConclusionCLBR is associated with E2 on trigger day in a segmented manner. Pregnancy and live birth rates in fresh cycles were not associated with E2. The live birth rate in FET cycles was highest when E2 ≥ 5000 pg/mL.

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“…Undoubtedly, β-hCG is essential for the maintained of pregnancy. Moreover, β-hCG is also involved in the regulation of progesterone expression via the ERK1/2 pathway [21], and promote cytotrophoblast differentiation and endometrial stromal cell decidualization [22,23]. P transforms the E 2 -prepared endometrium into a secretory tissue and creates a hospitable environment for embryo attachment [24].…”

Section: Hormones Involved In Regulating Uterine Changes During Place...mentioning

confidence: 99%

Combined analysis of estradiol and β-hCG to predict the early pregnancy outcome of FET: a retrospective study

Wu,

Xiao,

Wang

et al. 2024

Preprint

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Background How to accurately predicting the pregnancy outcomes of an IVF cycle are particularly important. Although a lot of work was conducted to predict pregnancy outcomes by assaying serum β-hCG levels after embryo transfer, rare study has focused on the prediction of serum E2 level after transfer. This study sought to analyze the predictive effect of serum E2 combined with β-hCG on early reproductive outcomes 12 days after embryo transfer. Methods A total of 1521 patients with β-hCG positive values on day 12 after frozen-warmed embryo transfer (FET) in natural endometrial preparation cycles (NCs) were collected in affiliated Women’s Hospital of Jiangnan University. Logistic regression analysis was constructed to establish the clinical pregnancy prediction model, and the cutoff value, optimal sensitivity and specificity were calculated by Receiver operating characteristic (ROC). Results Levels of serum E2 and β-hCG on the 12th day after FET with NCs were higher in clinical pregnancy group (CP Group) compared with biochemical pregnancy group (BP Group) (P < 0.001). Besides, the cutoff values for E2 and β-hCG on the 12th day after FET with NCs in cleavage group (CE Group) were 129.25 pg/mL and 156.60 mIU/mL respectively, with area under the ROC curve (AUC) of 0.801 and 0.941 respectively. For blastocyst group (B Group), the cutoff values for E2 and β-hCG were 174.45 pg/mL and 217.70 mIU/mL, with AUCs of 0.762 and 0.924 respectively. The logistic regression analysis revealed that serum E2 day 12 and β-hCGday 12 were significantly associated with clinical pregnancy. Conclusions Serum E2 is significantly different in CP Group compared with BP Group in FET with NCs. Earlier E2 combined with β-HCG can be used as a predictor of early pregnant state.

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Effect of Human Chorionic Gonadotropin Injection Before Frozen Embryo Transfer on Pregnancy Outcomes in Endometriosis-Associated Infertility

Cited by 10 publications

References 30 publications

Effect of human chorionic gonadotropin injection before frozen-thawed embryo transfer: A retrospective cohort study

Effect of human chorionic gonadotropin injection before frozen-thawed embryo transfer: A retrospective cohort study

Estradiol on trigger day: Irrelevant to live birth rates of fresh cycles but positively associated with cumulative live birth rates

Combined analysis of estradiol and β-hCG to predict the early pregnancy outcome of FET: a retrospective study

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