Effect of human immunodeficiency virus (HIV) infection on chronic hepatitis B hepatic viral antigen display

McDonald, J.A.; Harris, Stephanie A.; Waters, Jennifer A.; Thomas, Howard

doi:10.1016/s0168-8278(87)80543-3

Cited by 37 publications

(12 citation statements)

References 15 publications

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“…The anti-HIV activity of lamivudine, emtricitabine, tenofovir and lately entecavir [25] at present leaves only telbivudine, adefovir or pegylated interferon-a for the treatment of HBV alone. Clearly, the typically high HBV viral load found in HIV/HBVcoinfected patients [26] with the need for a potent regimen to achieve long-term viral suppression and avoid development of resistance represents quite a clinical challenge. So far, the efficacy of pegylated interferon in HBV/HIV-coinfected patients remains questionable given the lack of new data and lack of durable response with standard interferon in the pre-HAART era [27][28][29], whereas resistance development is the greatest concern for telbivudine or adefovir treatment or both.…”

Section: Anti-hepatitis B Virus Effect Of Highly Active Antiretroviramentioning

confidence: 99%

Liver disease: the effects of HIV and antiretroviral therapy and the implications for early antiretroviral therapy initiation

Vogel

Rockstroh

2009

Current Opinion in HIV and AIDS

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Section: Anti-hepatitis B Virus Effect Of Highly Active Antiretroviramentioning

confidence: 99%

Liver disease: the effects of HIV and antiretroviral therapy and the implications for early antiretroviral therapy initiation

Vogel

Rockstroh

2009

Current Opinion in HIV and AIDS

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“…† Higher levels of HBV replication, even in the presence of hepatitis delta virus (HDV) super-infection [4][5][6][7][8][9][10][11][12][13][14], related to HIV-induced CD4 depletion [14]. † A lower rate of spontaneous loss of HBeAg and/or HBsAg and seroconversion to anti-HBe and anti-HBs [4,5] with a high rate of seroreversion after CD4C cell depletion in those with spontaneous or interferoninduced anti-HBe seroconversion [15].…”

Section: Natural History Of Hbv-related Disease In Hiv-infected Patiementioning

confidence: 99%

Natural history of chronic hepatitis B in co-infected patients

Puoti¹,

Torti²,

Bruno³

et al. 2006

Journal of Hepatology

198

145

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“…In HBV mono-infection, active HBV replication is linked with increased severity of liver disease and liver-related mortality 8-11 .…”

Section: Discussionmentioning

confidence: 99%

HIV Through the Looking Glass

Rivera

Soza

Jazwinski

et al. 2015

JAIDS Journal of Acquired Immune Deficiency Syndromes

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Background While higher levels of hepatitis B virus (HBV) replication in HIV-HBV co-infection may relate to liver disease progression, this has not been completely elucidated. We utilized expression of hepatitis B core antigen (HBcAg) in liver biopsies from HIV-HBV co-infected and HBV mono-infected patients as a marker for HBV replication, and related these findings to clinical and histological parameters. Methods Data from 244 HBV patients were compared to 34 HIV-HBV patients. Liver biopsies were scored for inflammation, fibrosis, HBcAg, and hepatitis B surface antigen (HBsAg). Univariate and multivariate analyses were performed. Results HBcAg, but not HBsAg, staining was stronger in HIV co-infected than in HBV mono-infected. Co-infected and HBV mono-infected had similar ALT, inflammatory and fibrosis scores, and hepatitis B e Antigen (HBeAg) status. HBcAg staining correlated with HIV after correcting for HBV DNA and HBeAg. CD4 counts and HIV RNA level did not correlate with intensity of HBcAg staining. HBV DNA levels were higher in HIV co-infected and correlated with HBcAg staining. Conclusions By looking at HBcAg as a reflection of HBV replication in HIV-HBV co-infected with controlled HIV, our findings suggest that these patients may have subtle immune function defects, which could lead to adverse liver disease outcomes.

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Effect of human immunodeficiency virus (HIV) infection on chronic hepatitis B hepatic viral antigen display

Cited by 37 publications

References 15 publications

Liver disease: the effects of HIV and antiretroviral therapy and the implications for early antiretroviral therapy initiation

Liver disease: the effects of HIV and antiretroviral therapy and the implications for early antiretroviral therapy initiation

Natural history of chronic hepatitis B in co-infected patients

HIV Through the Looking Glass

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