Effect of human lactoferrin on Candida albicans infection and host response interactions in experimental oral candidiasis in mice

Pawar, Siddhi; Markowitz, Kenneth; Velliyagounder, Kabilan

doi:10.1016/j.archoralbio.2022.105399

Cited by 10 publications

(8 citation statements)

References 46 publications

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“…For bacteria, it enhances phagocytosis, suppresses biofilm formation, and hinders LPS-mediated activation while also altering the interactions between microbes and host cells [ 32 , 56 ]. Specifically, in the case of the fungus, as observed for Candida albicans, LF can trigger apoptosis [ 57 ]. Its antiviral properties are demonstrated by mitigating virus-induced cell apoptosis and obstructing the virus’s entry into cells.…”

Section: Genetics and Molecular Structurementioning

confidence: 99%

Exploring the Role of Lactoferrin in Managing Allergic Airway Diseases among Children: Unrevealing a Potential Breakthrough

Gori,

Brindisi,

Daglia

et al. 2024

Nutrients

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The prevalence of allergic diseases has dramatically increased among children in recent decades. These conditions significantly impact the quality of life of allergic children and their families. Lactoferrin, a multifunctional glycoprotein found in various biological fluids, is emerging as a promising immunomodulatory agent that can potentially alleviate allergic diseases in children. Lactoferrin’s multifaceted properties make it a compelling candidate for managing these conditions. Firstly, lactoferrin exhibits potent anti-inflammatory and antioxidant activities, which can mitigate the chronic inflammation characteristic of allergic diseases. Secondly, its iron-binding capabilities may help regulate the iron balance in allergic children, potentially influencing the severity of their symptoms. Lactoferrin also demonstrates antimicrobial properties, making it beneficial in preventing secondary infections often associated with respiratory allergies. Furthermore, its ability to modulate the immune response and regulate inflammatory pathways suggests its potential as an immune-balancing agent. This review of the current literature emphasises the need for further research to elucidate the precise roles of lactoferrin in allergic diseases. Harnessing the immunomodulatory potential of lactoferrin could provide a novel add-on approach to managing allergic diseases in children, offering hope for improved outcomes and an enhanced quality of life for paediatric patients and their families. As lactoferrin continues to capture the attention of researchers, its properties and diverse applications make it an intriguing subject of study with a rich history and a promising future.

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Section: Genetics and Molecular Structurementioning

confidence: 99%

Exploring the Role of Lactoferrin in Managing Allergic Airway Diseases among Children: Unrevealing a Potential Breakthrough

Gori,

Brindisi,

Daglia

et al. 2024

Nutrients

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“…Hasieran, laktoferrinaren jarduera antimikrobianoa burdina bahitzeko zuen gaitasunarekin erlazionatu bazen ere, duela gutxi egindako azterketen arabera, laktoferrinaren mekanismo antifungiko nagusia burdinarekiko independentea dela erakutsi dute, eta elkarrekintza hori proteina horrek mikroorganismoen zelula-gainazalarekin duen zuzeneko kontaktuaren bidez gertatzen dela deskribatu da. Horrek aldaketak eragiten ditu zelula-mintzaren iragazkortasunean, eta zelulaheriotza eragiten du (36,37). Laktoferrinak bakterioen aurkako defentsan duen papera ondo dokumentatuta badago ere, jarduera antifungikoa onddo batzuen aurrean soilik aztertu da, hala nola Aspergillus, Cryptococcus eta Candida espezie gutxi batzuen aurrean (37,38).…”

Section: Konposatu Naturalakunclassified

Zitral, kannabidiol eta laktoferrinaren konbinazioa flukonazolarekin Candida spp.ak sortutako infekzioak tratatzeko estrategia berri gisa

De-la-Fuente,

Guridi,

Cartón

et al. 2024

EKAIA

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LABURPENA: Farmakoekiko erresistenteak diren Candidaren isolamenduak eragindako kandidiasiaren intzidentziak gora egin du, eta horrek heriotza-tasa handiagoak ekartzeaz gain tratamendu-arazoak inplikatzen ditu, alternatiba terapeutiko berrien beharra areagotuz. Etorkizun handiko estrategietako bat farmako antifungikoak, hala nola flukonazola, eta berez jarduera antifungikorik erakusten ez duten beste konposatu batzuk konbinatzean datza, efektu sinergikoak lortzeko asmoz. Lan honen helburua flukonazola zitralarekin, kannabidiolarekin eta laktoferrinarekin konbinatzea izan zen, Candida espezieen aurka aktibitate antimikrobianoa aztertzeko. Aktibitatea xake-taularen metodoaren bidez ebaluatu zen, eta interakzioa kontzentrazio inhibitzaile zatikatuaren indizea kalkulatuz. Konposatu guztiek flukonazolaren kontzentrazio minimo inhibitzailea murriztea lortu zuten, nahiz eta desberdintasunak egon espezieen arabera. Efektu sinergikoak detektatu ziren zitrala eta laktoferrinarekin (2 eta 3 isolamenduetan, hurrenez hurren) eta gehigarria kannabidiolarekin eta laktoferrinarekin (2 isolamendu eta bakarrean, hurrenez hurren).

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“…In preclinical studies, hLF1-11 was effective in a mouse model of oral candidiasis and in a disseminated C. albicans infection in neutropenic mice. In this last study, it was also observed that hLF1-11 prevented the filamentous growth of the pathogen [ 39 , 100 ]. hLF1-11 has been the subject of one clinical trial that assessed the improvement of candidemia in patients, but it was withdrawn due to the unavailability of the patient population ( NCT00509834 ).…”

Section: Antimicrobial Peptides In Preclinical and Clinical Trialsmentioning

confidence: 99%

Antimicrobial Peptides: Avant-Garde Antifungal Agents to Fight against Medically Important Candida Species

et al. 2023

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Expanding the antifungal drug arsenal for treating Candida infections is crucial in this era of the rising life expectancy of patients with immunosuppression and comorbidities. Infections caused by Candida species are on the rise, including those caused by multidrug-resistant strains or species, and the list of antifungals approved for the treatment of these infections is still limited. Antimicrobial peptides (AMPs) are short cationic polypeptides whose antimicrobial activity is under intense investigation. In this review, we present a comprehensive summary of the AMPs with anti-Candida activity that have undergone successful preclinical or clinical trials. Their source, mode of action, and animal model of infection (or clinical trial) are presented. In addition, as some of these AMPs have been tested in combination therapy, the advantages of this approach, as well as the studied cases that have used AMPs and other drugs concomitantly to fight Candida infections, are described.

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Effect of human lactoferrin on Candida albicans infection and host response interactions in experimental oral candidiasis in mice

Cited by 10 publications

References 46 publications

Exploring the Role of Lactoferrin in Managing Allergic Airway Diseases among Children: Unrevealing a Potential Breakthrough

Exploring the Role of Lactoferrin in Managing Allergic Airway Diseases among Children: Unrevealing a Potential Breakthrough

Zitral, kannabidiol eta laktoferrinaren konbinazioa flukonazolarekin Candida spp.ak sortutako infekzioak tratatzeko estrategia berri gisa

Antimicrobial Peptides: Avant-Garde Antifungal Agents to Fight against Medically Important Candida Species

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