Effect of hyaluronic acid and vitamin E vaginal tablets on atrophic vaginitis: A randomized controlled trial

Ziagham, Sara; Abbaspoor, Zahra; Abbaspour, Mohammadreza

doi:10.5897/ajpp12.433

Cited by 8 publications

(18 citation statements)

References 16 publications

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“…All subjects in the included studies were accounted for. In the Ziagham et al’s studies [ 23 27 ], double-blinding was used, while Golmakani et al [ 28 ] described single-blinding (of investigators), and Parnan Emamverdikhan et al [ 29 ] did not comment on whether investigators were blinded to the subjects’ allocation group.…”

Section: Resultsmentioning

confidence: 99%

“…The four RCTs included in the review were all conducted in Iran through university-based health centers between 2010 and 2014 (see study characteristics, Table 2 ). Two eight-week trials reported by Ziagham et al [ 23 27 ] recruited women from 2010 to 2011, and two 12 weeks trials were reported by Parnan Emamverdikhan et al [ 29 ] and Golmakani et al [ 28 ], recruiting from 2013 to 2014. In all studies, the intervention was vaginal vitamin E suppositories in healthy postmenopausal women with genitourinary symptoms.…”

Section: Resultsmentioning

confidence: 99%

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Vaginal Vitamin E for Treatment of Genitourinary Syndrome of Menopause: A Systematic Review of Randomized Controlled Trials

et al. 2022

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Genitourinary syndrome of menopause significantly affects the quality of life in postmenopausal women with few evidence-based alternatives to vaginal estrogen for women with contraindications. This systematic review evaluates the evidence for vaginal vitamin E efficacy in reducing patient-reported genitourinary symptoms in healthy postmenopausal women compared to placebo or vaginal control therapy. This systematic review evaluated randomized controlled trials before October 2020 that assessed the efficacy of vitamin E vaginal suppositories in reducing genitourinary symptoms in postmenopausal women compared with a control group of healthy postmenopausal women. Outcomes included patient-perceived genitourinary symptoms. Of the 31 studies, four met the inclusion criteria. One 8-week trial (n = 42) found a significant reduction in vaginal symptoms in the 1 mg vitamin E group than the placebo group (difference in means, 5.3; 95% confidence interval [CI], 4.4 to 6.2). Another 8-week trial (n = 40) found 5 mg vaginal hyaluronic acid superior to 1 mg vitamin E (difference in means -0.50, 95% CI, -0.95 to -0.05). Two 12-week trials (n = 52 in each) found no difference between 0.5 g vaginal estrogen and 100 IU vaginal vitamin E in healthy postmenopausal women (difference in means: -0.19, 95% CI, -4.4 to 4.0, and -3.47, 95% CI, -13.8 to 6.8). Evidence from small, limited studies suggests that vaginal vitamin E may be effective in alleviating symptoms of genitourinary syndrome of menopause; however, additional high-quality studies are needed to determine efficacy, ideal dosing, and long-term safety.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Vaginal Vitamin E for Treatment of Genitourinary Syndrome of Menopause: A Systematic Review of Randomized Controlled Trials

et al. 2022

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“…The climacteric phase and menopause are the periods of reductions in the production of hormones, that can affect women's quality of life because of various complications [4]. These complications can include symptoms such as hot flushes, night sweats, palpitations, bone loss, urinary problems, and vaginal dryness [5].…”

Section: Introductionmentioning

confidence: 99%

“…In addition, dyspareunia can cause sexual dysfunction and loss of sexual desire during menopause [6]. Vaginal atrophy, after hot flushes, is the second most common complication and is the worst complication of menopause [4]. Reducing estrogen levels through causing fractures in collagen and elastin fibers in the vagina causes vaginal atrophy.…”

Section: Introductionmentioning

confidence: 99%

Investigating the effect of vitamin D vaginal suppository on sexual function among postmenopausal women: study protocol for a randomized controlled trial

Sarebani¹,

Alimoradi²,

Aali³

et al. 2020

BMC Women's Health

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Background: Menopause is associated with changes in sexual function which are partly due to vaginal atrophy in response to estrogen reduction. Estrogen administration temporarily reduces the symptoms of vaginal dryness, but long-term exposure to this drug is likely to be associated with serious complications. Considering the promising results of previous studies concerning the effect of vitamin D on vaginal dryness, the proposed study will investigate the effect of vitamin D vaginal suppository on the sexual function of postmenopausal women.Methods: In a randomized, controlled clinical trial, 105 postmenopausal women will be randomly assigned to three groups receiving vitamin D vaginal suppository, placebo vaginal suppository, or control (no intervention). Vitamin D vaginal suppositories contain 1000 units of vitamin D3. The timing of the use of vitamin D vaginal suppositories and placebo suppositories will be every night in the first 2 weeks, and every other night in the following 6 weeks (8 weeks in total). The primary outcome will be the sexual function of participants which will be assessed using the Female Sexual Function Index (FSFI) before and immediately after the intervention, and at 1 and 2 months after the end of the intervention. The side effects of these suppositories will be examined as a secondary consequence of the study. Data will be analyzed using SPSS software version 25. In the case of normal distribution of data, the mean score of sexual function will be compared between the groups using a repeated measurements ANOVA. If statistical analysis leads to significant results, the post-hoc test will be used to determine the differences between the groups. Comparison of demographic and fertility characteristics of the women will be carried out using statistical tests such as chi-squares and t-tests. A significance level of p < .05 will be used for statistical analyses.Discussion: If vitamin D vaginal suppositories improve sexual function among premenopausal women with longterm effects and minimum side effects, the suppositories will be considered a safe complementary and alternative choice for alleviating sexual dysfunction among this group.Trial registration: IRCT20180704040346N1 at 2018-10-13 prospectively registered.

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“…Due to the emergence of numerous health problems during this period, investigating factors that reduce and treat these problems play an essential role in improving life quality in postmenopausal women. [ 2 ]…”

Section: Introductionmentioning

confidence: 99%

Effect of Trigonella foenum (fenugreek) vaginal cream on vaginal atrophy in postmenopausal women

Mazalzadeh

Hekmat

Namjouyan

et al. 2020

J Family Med Prim Care

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Background and Objective: Menopause forms one-third of women's lives. During this period, many women continue their sexual activities. One of the most prevalent postmenopausal complications is vaginal atrophy whose symptoms could have destructive effects on the life quality among postmenopausal women. Complications of using estrogen hormone to improve these symptoms are inevitable. One of the objectives of the present study is the assessment of the vaginal cream of Fenugreek on vaginal inflammation of atrophic vaginitis in postmenopausal women. Materials and Methods: For assessment of the effect of fenugreek vaginal cream among postmenopausal women who suffer from vaginal atrophy, the present study was carried out in the form of a double-blind clinical trial among sixty postmenopausal women, mainly who had been referred to Health Center 1 located in the east of Ahvaz in 2017. All participants of the present study who were diagnosed with vaginal atrophy were assigned into two groups of 30 randomly. One of these groups received placebo and the other one fenugreek 5% vaginal cream for a period of 8 weeks. Symptoms related to vaginal atrophy were investigated by means of a 4-degree scale (none, mild, moderate, and severe) and maturation vaginal index (MVI) through preparing the vaginal smears technique at baseline and a period of 8 weeks after cytology and intervention experiment. Finally, the process of analyzing statistical data, at a statistical significance level of 0.05, was carried out by means of SPSS Software. Results: The results of the present study demonstrated that the fenugreek vaginal cream treatment group experienced a significant improvement in vaginal atrophy symptoms compared to the onset of the study ( P < 0.001). Conclusion: Fenugreek vaginal cream was effective in treating vaginal atrophy; therefore, postmenopausal women are recommended to use this cream instead of synthetic estrogen to reduce the complications of this hormone.

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Effect of hyaluronic acid and vitamin E vaginal tablets on atrophic vaginitis: A randomized controlled trial

Cited by 8 publications

References 16 publications

Vaginal Vitamin E for Treatment of Genitourinary Syndrome of Menopause: A Systematic Review of Randomized Controlled Trials

Vaginal Vitamin E for Treatment of Genitourinary Syndrome of Menopause: A Systematic Review of Randomized Controlled Trials

Investigating the effect of vitamin D vaginal suppository on sexual function among postmenopausal women: study protocol for a randomized controlled trial

Effect of Trigonella foenum (fenugreek) vaginal cream on vaginal atrophy in postmenopausal women

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