Effect of Hyaluronic Acid-Enriched Media in Embryo Implantation

Abstract

EmbryoGlue (Vitrolife, Sweden) is a hyaluronan-rich medium manufactured specifically for embryo transfer. Normally, culture media is used for embryo transfer. Culture media is enriched with albumin. Embryo transfer success depends upon the implantation rate. According to some researchers, hyaluronic acid-enriched media may be responsible for the success of embryo transfers. The aim of the study is to check the efficacy of hyaluronic acid-enriched media for previous in-vitro fertilization (IVF) failure patients. A 48year patient was unable to conceive naturally for 20 years. The patient was enrolled for an IVF cycle at Wardha Test Tube Baby Centre in November 2020. The patient was enrolled for three IVF cycles. She was counseled for IVF treatment after failure of three intrauterine inseminations (IUI). Due to menopause, the patient was suggested for IVF with a donor egg and husband's sperm. The uterine septum was found in hysteroscopy and a septum section was done. The patient was conceived after the sixth embryo transfer by using EmbryoGlue. The case report highlighted that the pregnancy may be achieved by the use of EmbryoGlue for embryo transfer.

Exploring the Role of Hyaluronic Acid in Reproductive Biology and Beyond: Applications in Assisted Reproduction and Tissue Engineering

“…failures. [101] Valojerdi et al investigated the effectiveness of Em-bryoGlue in 417 patients as a human embryo transfer medium, reporting an increase in the clinical pregnancy and implantation rate in the tubal factors and repeated implantation failures. Furthermore, compared to 398 patients in the control group, these patients had considerably higher rates of live births and triplet deliveries.…”

Application of Physiological Sperm Selection in Assisted Reproductive Technology (ART) for Patients With Diabetes Mellitus: A Case Report

“…Also, the earlier studies demonstrate that the metabolism of glucose is a very important factor for sperm, and type 1 or type 2 diabetes can have harmful effects on the fertility of the male partner, especially on the quality of sperm cells, like motility, the integrity of sperm DNA, and the composition of semen [ 5 ]. There are many reasons for embryo transfer failure, including endometrial thickness, receptivity, embryo abnormalities, and inherited factors [ 6 ].…”

“…One way of assessing sperm quality has been suggested: selecting suitable sperm based on its capacity to attach to HA [8]. A recent study has shown that using HA as a medium may have a greater beneficial effect on clinical pregnancy success [6]. PICSI works by choosing sperm based on the oocyte's affinity for HA, leading to higher ICSI success rates [10].…”

Effect of Hyaluronic Acid-Containing Transfer Media (EmbryoGlue®) on the Live Birth Rate in Frozen Thawed Embryo Transfer Cycles

“…EmbryoGlue® (VitroLife, Sweden) is typically composed of hyaluronan (high concentration of HA (0.5 mg/mL)), a natural substance in the female reproductive tract, and other nutrients (low concentration of recombinant human albumin (rHA = 2.5 mg/mL)) supporting the embryo. The embryo glue is believed to improve the chances of successful implantation by helping the embryo adhere to the endometrium and promoting communication between the embryo and the uterine environment [ 8 ].…”