Effect of hyaluronic acid–enriched transfer medium on frozen–thawed embryo transfer outcomes

Fu, Wei; Yu, Min; Zhang, Xiaojin

doi:10.1111/jog.13581

Cited by 10 publications

(5 citation statements)

References 30 publications

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“…Our results are in agreement with those of previous studies ( 30 ), which showed that the addition of HA to the transfer medium in patients with RIF significantly increased the implantation and clinical pregnancy rates while not affecting the ectopic pregnancy and abortion rates. The mechanism of this beneficial effect might be that the addition of HA to the transfer medium increases its viscosity, which may enhance the embryo transfer process and reduce the possibility of the expulsion of embryos from the uterine cavity after transfer.…”

Section: Discussionsupporting

confidence: 93%

Effect of hyaluronic acid-enriched transfer medium on frozen–thawed embryo transfer outcomes in RIF patients: a single-centre retrospective study

et al. 2023

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IntroductionMany patients who undergo assisted reproductive technology (ART) suffer from recurrent implantation failure (RIF). The addition of hyaluronic acid (HA) to the transfer medium is one of several methods to improve pregnancy outcomes. We investigated whether HA could improve the live birth and clinical pregnancy rates of RIF patients.MethodsThis study included 248 RIF patients, who were divided into two groups: the control (CTL) group (n=137), which received transfer medium without HA, and the HA group (n=111), which received transfer medium with HA. The two groups were compared according to the ART outcome.ResultsThe primary outcomes were the clinical pregnancy and live birth rates. Secondary outcomes include a positive urine pregnancy test, the implantation, ongoing pregnancy, multiple pregnancy, clinical miscarriage, and ectopic pregnancy rates, foetal or congenital defects, obstetric complications, infant birth weight and any related adverse events. Regarding the primary outcomes, the clinical pregnancy rate was significantly higher in the HA group than in the control group, and there was no significant difference in the live birth rate (LBR) between the HA and control groups. Regarding the secondary outcomes, the implantation, multiple pregnancy and ectopic pregnancy rates were similar between the two groups.DiscussionOur findings supported the conclusion that HA can improve the clinical pregnancy rate of patients with RIF undergoing FET cycles, but the live birth rate was not significantly improved with the addition of HA to the traditional transfer medium.

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Section: Discussionsupporting

confidence: 93%

Effect of hyaluronic acid-enriched transfer medium on frozen–thawed embryo transfer outcomes in RIF patients: a single-centre retrospective study

et al. 2023

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“…HA-enriched media may increase the implantation rate 14 and clinical pregnancies in patients with previous failed implants and in the third or more attempts after cryo ET. 10,15 They also report that clinical pregnancies and implantation rates were higher in embryos after cryo ET, indicating that the viscosity of the EG medium physically protects embryos after assisted hatching. 13 Zhang et al 16 and Wu et al 17 investigated whether EG has an impact on pregnancy outcome during in vitro fertilisation compared to G2 medium.…”

Section: Discussionmentioning

confidence: 97%

Influence of EmbryoGlue® transfer medium on implantation of human embryos

Pavlović-Vasić¹,

Sibinčić²,

Milaković³

et al. 2021

Scripta Medica

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Introduction: Thanks to ever-growing advances in medical science, couples who are in the in vitro fertilisation (IVF) now have more options than ever to encase their chances at a successful pregnancy. One of the options is the use of EmbryoGlue (EG), that creates a bridge between the embryo and the uterus and provides protection to the embryo itself during the transfer process. Aim of this study was to determine whether EG medium is of greater importance for embryo implantation than conventional medium in assisted reproductive technology and compare the rate of embryo implantation with EG and conventional medium in relation to the quality of the embryo, the age of the patients and tobacco smoking. Methods: The retrospective study included 50 patients who used EG medium in embryo transfer (ET) and 50 patients in the control group using conventional medium. All patients underwent ET after stimulation of the cycle according to a short protocol. ETs were done on Day 2, 3, or 5 in the blastocyst stage. Age and smoking status were recorded. Results: Out of a total of 100 patients, 42 patients had successful implantation and positive b-hCG 15 days after ET. In a control group 38 % had positive b-hCG and in the group of patients who used EG 46 %. A higher rate of embryo implantation success was observed on the second day of transfer in the group of patients using EG. In the EG group a significant increase in the embryo implantation rate was observed in patients older than 35. In tobacco smokers the implantation rate was higher if they used EG during ET. Conclusion: EG medium had a positive effect on the second day of ET, patients above the age of 35 and patients who were tobacco smokers.

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“…First-time FET patients or those with one previous FET have no significant clinical benefit with the use of HETM, whereas patients on their third or higher FET attempt resulted in a statistically significant increase in implantation (33.3 vs. 16.4%) and pregnancy rate (52.2 vs. 27.4%) when compared with standard media (p < 0.001, n ¼ 1,632). 20 Conversely, the use of EmbryoGlue in donor FET cycles following preimplantation genetic testing (PGT) did not show any significant improvement in clinical pregnancy rates or any significant decrease in rates of miscarriage (p ¼ 0.32), although it should be noted that this was a small case-control study (n ¼ 37) which may limit the significance of the results. 21 The short protocol for EmbryoGlue provided by Vitrolife states that embryos can be held in EmbryoGlue for a minimum of 10 minutes and a maximum of 4 hours prior to transfer.…”

Section: Recent Evidencementioning

confidence: 89%

Embryo Glue: The Use of Hyaluronan in Embryo Transfer Media

Atkinson

Woodland

2021

Semin Reprod Med

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EmbryoGlue is available to patients at many in vitro fertilization clinics, usually at an additional cost. The efficacy of hyaluronan-enriched transfer medium (HETM) is supported by moderate quality evidence that indicates a significant improvement in clinical outcomes such as live birth rates for patients, including poorer prognosis women (i.e., maternal age factor [>35 years] and recurrent implantation failure). An increased multiple pregnancy rate has been reported with the use of HETM; therefore, a single embryo transfer policy should be considered in conjunction with the use of EmbryoGlue. There is no evidence to suggest that HETM has any detrimental impact, and therefore the use of HETM in clinics may be justified for a specific demographic of patients. Further robust evidence, in the form of meta-analyses or large-scale randomized controlled trials, is needed to build a sufficient consensus regarding the benefit of hyaluronan supplementation in embryo transfer media.

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Effect of hyaluronic acid–enriched transfer medium on frozen–thawed embryo transfer outcomes

Abstract: HETM can improve the embryo IR and clinical PR in patients with repeated implantation failure in the third or more FET attempt. However, the use of HETM for first and second FET should be done with caution.

Cited by 10 publications

References 30 publications

Effect of hyaluronic acid-enriched transfer medium on frozen–thawed embryo transfer outcomes in RIF patients: a single-centre retrospective study

Effect of hyaluronic acid-enriched transfer medium on frozen–thawed embryo transfer outcomes in RIF patients: a single-centre retrospective study

Influence of EmbryoGlue® transfer medium on implantation of human embryos

Embryo Glue: The Use of Hyaluronan in Embryo Transfer Media

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