Effect of hyaluronic acid on morphological changes to dentin surfaces and subsequent effect on periodontal ligament cell survival, attachment, and spreading

Abstract

HA is a highly biocompatible material that may improve PDL cell attachment or spreading on dentin.

Effect of curing conditions on physical and chemical properties of MTA+

“…, Mueller et al . ). On the other hand, irregularities produce a friendly environment for initial bacterial adhesion (Ota‐Tsuzuki et al .…”

“…Surface roughness affects cell adhesion to materials and dental tissues. The micro-rough surfaces of dental tissues may be advantageous for initial cell and tissue adhesion (Belal et al 2007, Raldi et al 2010, Eick et al 2013, Attic et al 2014, Mueller et al 2017). On the other hand, irregularities produce a friendly environment for initial bacterial adhesion (Ota-Tsuzuki et al 2009, Dangaria et al 2011).…”

The in vitro effect of leukocyte- and platelet-rich fibrin (L-PRF) and cross-linked hyaluronic acid on fibroblast viability and proliferation

“…[2][3][4][5] Hyaluronic acid (HA) is an anionic, glycosaminoglycan. 6,7 It is a naturally occurring molecule that is found in high concentrations in the extracellular matrix of skin, cartilage, bone and periodontal ligament. 7 Even though the exact function of HA has not yet been established, the molecule shows a wide range of physiological actions, acting as a The in vitro effect of leukocyte-and platelet-rich fibrin (L-PRF) and crosslinked hyaluronic acid on fibroblast viability and proliferation.…”

“…http://dx.doi.org/10.17159/2519-0105/2018/v73no6a2 VeGF: vascular endothelial growth factor cellular scaffold, stimulating cell adhesion and migration, as well as having anti-inflammatory effects. 7 Commercially synthesized HA, in various forms, has been used in tissue engineering, dermatology, orthopaedics, and more recently, periodontal regeneration. [7][8][9][10] Traditionally, two forms of commercially synthesized HA exist, i.e., non-cross-linked HA, and cross-linked-HA, resulting in different properties and indications for each form of HA.…”

“…cross-linked ha A limited number of studies have reported on the cell stimulating potential of the specific high molecular weight clHA used in the present study. 6,7 Previous research indicates that this formulation is biocompatible and is able to positively stimulate the proliferation of periodontal ligament cells in vitro. 6 These results were statistically significant when the biomaterial was diluted at ratios of 1:100 and 1:10.…”