Effect of Hyaluronidase Addition to Lidocaine for Trigger Point Injection in Myofascial Pain Syndrome

Choi, Ji Won; Lee, Chul Joong; Lee, Sangmin M.; Shin, Byung Seop; Jun, Byunghui; Sim, Woo Seog

doi:10.1111/papr.12362

Cited by 4 publications

(2 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This can result in dysfunctional deep fascial planes gliding over each other and over muscle, which predicts the basis of MFP 11 . In a randomized, double‐blind study following 61 adults with MFP of trapezius muscles for 14 days post trigger point injection (TPI), it was found that adults who received TPI with hyaluronidase/lidocaine had better post TPI soreness than those who only had lidocaine TPI 45 . Another randomized single‐blind study of patients with trapezius MFP showed that hyaluronidase TPI was superior to bicarbonate and lidocaine in reducing visual analogue scale 4 weeks after the injections 46 …”

Section: Hyaluronan and Painmentioning

confidence: 99%

Hyaluronan homeostasis and its role in pain and muscle stiffness

Amir

Kim

Stecco

et al. 2022

PM&R

View full text Add to dashboard Cite

Hyaluronan (HA) is a glycosaminoglycan that consists of single-chain polymers of disaccharide units of glucuronic acid and N-acetylglucosamine. It is a chief constituent of the extracellular matrix. About 27% of the total HA in the body is expressed in the skeleton and connective tissue, while 8% is expressed in muscles. In physiological conditions, HA functions as a lubricant and viscoelastic shock absorber. Additionally, HA is part of complex cellular signaling which modulates nociception and inflammation. This study aims to understand the role that HA plays in the musculoskeletal system, specifically in muscles and the surrounding fascia. This review is also intended to further understand HA homeostasis and the process of its synthesis, degradation, and clearance from the local tissue. The authors examined muscle pain and stiffness as pathological conditions associated with HA accumulation.

show abstract

Section: Hyaluronan and Painmentioning

confidence: 99%

Hyaluronan homeostasis and its role in pain and muscle stiffness

Amir

Kim

Stecco

et al. 2022

PM&R

View full text Add to dashboard Cite

show abstract

“…Although pain related to the injection of normal saline is more than local anesthesia, the results of some studies indicate more pain related to injection, but findings are controversial ( 8 - 10 ). Cho et al investigated the injection of a combination of hyaluronidase and lidocaine on myofascial pain ( 11 ). Findings showed that injection of a combination of hyaluronidase and lidocaine is more effective than lidocaine alone.…”

Section: Introductionmentioning

confidence: 99%

Comparison of the Effect of Bicarbonate, Hyaluronidase, and Lidocaine Injection on Myofascial Pain Syndrome

et al. 2020

View full text Add to dashboard Cite

Background: Myofascial pain syndrome is a chronic syndrome that occurred in a local or focal part of the body. The basis for myofascial pain syndrome is the presence of myofascial trigger point or points, producing pain in clinical examinations. Objectives: This study aimed to compare the effect of injection of bicarbonate, hyaluronidase, and lidocaine on myofascial pain syndrome. Methods: The patients were randomly allocated to three groups of bicarbonate, hyaluronidase, and lidocaine. The injection was done at two painful regions of trapezius muscle with a sonography guide for each patient. The values of visual analogue scale (VAS), pre-injection range of motion (ROM), immediately after injection, second and fourth week were measured. Results: The analysis showed that there were no significant differences between the three groups for age, gender, BMI, and height (P > 0.05). Repeated measures one-way ANOVA (week * group) 4 * 3 was used to compare the effect of bicarbonate, hyaluronidase, and lidocaine on VAS and range of motion (ROM) before injection, immediately after injection, second and fourth week. The results showed that the main effect of group and week is significant for VAS (P < 0.05). This study showed that the values of VAS were significantly different between the three groups during the fourth weeks of the study. Moreover, the patients experienced more pain decline in the hyaluronidase group during weeks before injection, after injection, second and fourth week, which indicated the permanent effect of this medication on pain decline. Conclusions: Injection of lidocaine leads to a significant reduction in pain immediately after injection; however, the decline was not permanent and disappeared in the following four weeks. But VAS reduction in hyaluronidase group more than bicarbonate and lidocaine groups.

show abstract

Combination pharmacotherapy for the treatment of fibromyalgia in adults

Thorpe

Shum

Moore³

et al. 2018

Cochrane Database of Systematic Reviews

View full text Add to dashboard Cite

BackgroundFibromyalgia is a chronic widespread pain condition a ecting millions of people worldwide. Current pharmacotherapies are o en ine ective and poorly tolerated. Combining di erent agents could provide superior pain relief and possibly also fewer side e ects. ObjectivesTo assess the e icacy, safety, and tolerability of combination pharmacotherapy compared to monotherapy or placebo, or both, for the treatment of fibromyalgia pain in adults. Search methodsWe searched CENTRAL, MEDLINE, and Embase to September 2017. We also searched reference lists of other reviews and trials registries. Selection criteriaDouble-blind, randomised controlled trials comparing combinations of two or more drugs to placebo or other comparators, or both, for the treatment of fibromyalgia pain. Data collection and analysisFrom all studies, we extracted data on: participant-reported pain relief of 30% or 50% or greater; patient global impression of clinical change (PGIC) much or very much improved or very much improved; any other pain-related outcome of improvement; withdrawals (lack of e icacy, adverse events), participants experiencing any adverse event, serious adverse events, and specific adverse events (e.g. somnolence and dizziness). The primary comparison was between combination and one or all single-agent comparators. We also assessed the evidence using GRADE and created a 'Summary of findings' table. Main resultsWe identified 16 studies with 1474 participants. Three studies combined a non-steroidal anti-inflammatory drug (NSAID) with a benzodiazepine (306 participants); two combined amitriptyline with fluoxetine (89 participants); two combined amitriptyline with a di erent agent (92 participants); two combined melatonin with an antidepressant (164 participants); one combined carisoprodol, paracetamol (acetaminophen), and ca eine (58 participants); one combined tramadol and paracetamol (acetaminophen) (315 participants); one combined malic acid and magnesium (24 participants); one combined a monoamine oxidase inhibitor with 5hydroxytryptophan (200 participants); and one combined pregabalin with duloxetine (41 participants). Six studies compared the combination of multiple agents with each component alone and with inactive placebo; three studies compared combination Combination pharmacotherapy for the treatment of fibromyalgia in adults (Review)

show abstract

Effect of Hyaluronidase Addition to Lidocaine for Trigger Point Injection in Myofascial Pain Syndrome

Cited by 4 publications

References 28 publications

Hyaluronan homeostasis and its role in pain and muscle stiffness

Hyaluronan homeostasis and its role in pain and muscle stiffness

Comparison of the Effect of Bicarbonate, Hyaluronidase, and Lidocaine Injection on Myofascial Pain Syndrome

Combination pharmacotherapy for the treatment of fibromyalgia in adults

Contact Info

Product

Resources

About