Effect of hydraulic conditions on the prevalence of antibiotic resistance in water supply systems

Zhang, Junpeng; Li, Weiying; Chen, Jiping; Wang, Feng; Qi, Wanqi; Li, Yue; Xie, Bing

doi:10.1016/j.chemosphere.2019.06.157

Cited by 21 publications

(4 citation statements)

References 28 publications

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“…Studies have shown that, when compared to WDSs with high velocity water flows (>0.3 m/sec), those with low velocity flows have lower hydrodynamic shear forces at the internal surface of their pipes, which leads to growth of thicker, less dense and less stable biofilms [ 41 , 42 , 43 ]. Further to this, low velocity water flows through pipes lead to higher concentrations of antimicrobial-resistant bacteria (ARB) and a higher prevalence of antimicrobial-resistant genes (ARGs), and different microbial community compositions than are found in pipes with higher velocity water flow [ 44 , 45 , 46 ]. Exposure of microbial communities in biofilms to sub-inhibitory antimicrobial concentrations, which is likely in pig building WDSs, especially during lower metaphylactic in-water dosing events conducted over >12 h, could also modulate biofilm matrix composition.…”

Section: Discussionmentioning

confidence: 99%

Effect of Drinking Water Distribution System Design on Antimicrobial Delivery to Pigs

Little

Woodward

Browning

et al. 2021

Animals

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On many pig farms, growing pigs are mass-medicated for short periods with antimicrobial drugs through their drinking water for metaphylaxis and to treat clinical disease. We conducted a series of four prospective observational cohort studies of routine metaphylactic in-water antibiotic dosing events on a commercial pig farm, to assess the concentration of antimicrobial available to pigs throughout a building over time. Each dosing event was conducted by the farm manager with a differently designed looped water distribution system (WDS). We found that the antimicrobial concentration in water delivered to pigs at drinkers in each pen by a building’s WDS over time was profoundly influenced by the design of the WDS and the pigs’ water usage and drinking pattern, and that differences in the antimicrobial concentration in water over time at drinkers throughout a building could be eliminated through use of a circulator pump in a looped WDS. We also used a hydraulic WDS modelling tool to predict the antimicrobial concentration at drinkers over time during and after a dosing event. Our approach could be used to evaluate alternative in-water dosing regimens for pigs in a specific building in terms of their clinical efficacy and ability to suppress the emergence of antimicrobial resistance, and to determine the optimal regimen. The approach is applicable to all additives administered through drinking water for which the degree of efficacy is dependent on the dose administered.

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Section: Discussionmentioning

confidence: 99%

Effect of Drinking Water Distribution System Design on Antimicrobial Delivery to Pigs

Little

Woodward

Browning

et al. 2021

Animals

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“…The results showed that the most abundant microbial taxa were Proteobacteria, Actinobacteria, and Bacteroidetes. Proteobacteria and Actinobacteria are known to be important carriers of ARGs and are also detected as the most abundant bacterial phyla in many other environments, such as water supply pipes and networks [ 42 , 43 , 44 , 45 ]. Proteobacteria is associated with a range of diseases, including metabolic disorders, inflammatory bowel disease, and lung disease [ 46 ].…”

Section: Resultsmentioning

confidence: 99%

Assessing Antibiotic-Resistant Genes in University Dormitory Washing Machines

Chen,

Zhang,

2024

Microorganisms

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University dormitories represent densely populated environments, and washing machines are potential sites for the spread of bacteria and microbes. However, the extent of antibiotic resistance gene (ARG) variation in washing machines within university dormitories and their potential health risks are largely unknown. To disclose the occurrence of ARGs and antibiotic-resistant bacteria from university dormitories, we collected samples from washing machines in 10 dormitories and used metagenomic sequencing technology to determine microbial and ARG abundance. Our results showed abundant microbial diversity, with Proteobacteria being the dominant microorganism that harbors many ARGs. The majority of the existing ARGs were associated with antibiotic target alteration and efflux, conferring multidrug resistance. We identified tnpA and IS91 as the most abundant mobile genetic elements (MGEs) in washing machines and found that Micavibrio aeruginosavorus, Aquincola tertiaricarbonis, and Mycolicibacterium iranicum had high levels of ARGs. Our study highlights the potential transmission of pathogens from washing machines to humans and the surrounding environment. Pollution in washing machines poses a severe threat to public health and demands attention. Therefore, it is crucial to explore effective methods for reducing the reproduction of multidrug resistance.

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“…In this way, they pose serious threats (such as death, deadly and, sometimes, long-term infections) to human health. This expansion of potential bacterial resistance can be accomplished through horizontal transfer of genes (HGT), plasmids, transposons and integrons among different bacterial species [8,[18][19][20][21]. In large cities, drinking water is often supplied from surface water resources close to the city after proper and strict treatment processes [22].…”

Section: Introductionmentioning

confidence: 99%

“…Depending on the concentration of chlorine in the water, bacteria use different strategies to resist and transmit ARGs [17,29]. In some studies, the frequency of mobile genetic elements (MGEs), including integrons and plasmids, increases after chlorination, which accelerates ARG transfer [20,25,30]. The results of some studies show that chlorination increases ARGs [22,25,28], while the results of some other studies indicate a decrease in ARGs after chlorination [31][32][33][34].…”

Section: Introductionmentioning

confidence: 99%

What is the effect on antibiotic resistant genes of chlorine disinfection in drinking water supply systems? A systematic review protocol

et al. 2022

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Background Antibiotic-resistant bacteria (ARB) usually enter water sources in different ways, such as via municipal and hospital wastewaters. Because conventional technologies used to treat water inefficient in removing these contaminants (especially antibiotic-resistant genes; ARGs), these contaminants easily enter drinking water distribution networks and pose serious threats to consumers’ health. This study’s main purpose is to systematically investigate the effect of chlorine disinfection on ARGs in drinking water supply systems. This study could play an important role in elucidating the effect of chlorine disinfection on ARGs. Methods The systematic review outlining this protocol will be performed according to the Collaboration for Environmental Evidence (CEE) guidelines. The main question is, “what is the effect of chlorine disinfection on ARGs in drinking water supply systems?” For this purpose, the articles will be considered, in which chlorine’s effect on ARGs is investigated. The search includes electronic resources, grey literature, and related websites. Electronic resources include Scopus, PubMed, Embase, Web of Science Core Collection, and Science Direct. After the final search, the obtained articles will be collected in the reference management software (Endnote X8). Upon removing the duplicate articles, the first stage of article screening will be performed based on the title and abstract the articles. In the second stage, the articles obtained from the first screening stage will be screened based on the full text of the articles based on the eligibility criteria. Then, two members of the expert team extract the data. To assess the validity of the articles, bias sources will be determined by an expert team. Biases will be defined according to the criteria designed by Bilotta et al. Finally, a narrative synthesis will be performed for the extracted data; if appropriate data are available, quantitative analysis will also be performed.

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Effect of hydraulic conditions on the prevalence of antibiotic resistance in water supply systems

Cited by 21 publications

References 28 publications

Effect of Drinking Water Distribution System Design on Antimicrobial Delivery to Pigs

Effect of Drinking Water Distribution System Design on Antimicrobial Delivery to Pigs

Assessing Antibiotic-Resistant Genes in University Dormitory Washing Machines

What is the effect on antibiotic resistant genes of chlorine disinfection in drinking water supply systems? A systematic review protocol

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