Effect of hydroalcohol extract of lemon (&lt;i&gt;Citrus limon&lt;/i&gt;) peel on a rat model of type 2 diabetes

Lv, Juan; Cao, Liu; Li, Min; Zhang, Rui; Bai, Feng‐Wu; Wei, Pengfei

doi:10.4314/tjpr.v17i7.20

Cited by 7 publications

(2 citation statements)

References 15 publications

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“…Lemon peel constituents might be helpful in the control of T2DM and could reduce diabetes-related chronic illness risk. Several studies have shown the antidiabetic effect of lemon peel extract on a rat model of T2DM (48).…”

Section: Discussionmentioning

confidence: 99%

Chemical composition of essential oils of Citrus limon peel from three Moroccan regions and their antioxidant, anti-inflammatory, antidiabetic and dermatoprotective properties

Aboubi

Hdech²,

Bikri

et al. 2022

J Herbmed Pharmacol

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Introduction: The current study aimed to explore the in vitro antioxidant, anti-inflammatory, antidiabetic, and dermatoprotective properties of lemon peel essential oil (EO). Methods: The chemical composition of lemon EOs extracted from the lemon of three cities in Morocco was investigated using gas chromatography-mass spectrometry (GC-MS) analysis. The antioxidant property was estimated by two complementary tests: Ferric ion reducing antioxidant power (FRAP) and 1,1-diphenyl-2-picrylhydrazyl (DPPH). The in vitro anti-inflammatory activity was assessed by the inhibition of albumin denaturation and proteinase. Inhibitory properties of α-glucosidase and α-amylase were used to reveal the antidiabetic activity of lemon peel EOs. Dermatoprotective property was evaluated by the tyrosinase inhibition method. Results: In addition to high amounts of polyphenols and flavonoids, GC-MS analysis of lemon peel EOs demonstrated the presence of D-limonene, β–pinene, and γ-terpinene as the main compounds in the three samples studied. Lemon peel EOs exhibited significant antioxidant activities by IC50 values ranging from 40.57 µg/mL to 100.22 µg/mL and 113.63 µg/mL to 180.90 µg/mL obtained by DPPH and FRAP tests, respectively. in vitro inhibition of enzymes involved in inflammatory response revealed that lemon peel EOs presented remarkable inhibitory activities against albumin denaturation (230.48 µg/mL>IC50<341.13 µg/mL) and proteinase (199.70 µg/mL>IC50<307.05 µg/mL). Moreover, lemon peel EOs demonstrated powerful inhibition of α-amylase and α-glucosidase with various IC50 values (1689.06 µg/ mL>IC50>4000 µg/mL and 1021.58 µg/mL>C50<2467.62 µg/mL), respectively. These EOs also revealed significant inhibition of tyrosinase with IC50 values ranging from 248.42 μg/ mL to 378.02 μg/mL. Conclusion: These results revealed that lemon peel EOs might constitute a new product with beneficial biological abilities against the mentioned complications.

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Section: Discussionmentioning

confidence: 99%

Chemical composition of essential oils of Citrus limon peel from three Moroccan regions and their antioxidant, anti-inflammatory, antidiabetic and dermatoprotective properties

Aboubi

Hdech²,

Bikri

et al. 2022

J Herbmed Pharmacol

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“…Recent publications have reported that C. limon flavonoids, particularly hesperidin, hesperetin, naringin, and naringenin, significantly decrease hyperglycemia by several action mechanisms (Alam et al, 2014;Lv et al, 2018). Akiyama et al (2009) conducted an experimental study that showed that hesperidin significantly reduces blood glucose in diabetic rats by stimulating insulin secretion and regulating glucose metabolism in the liver.…”

Section: Limon (Rutaceae)mentioning

confidence: 99%

Traditional medicinal plants used in the treatment of diabetes: Ethnobotanical and ethnopharmacological studies and mechanisms of action

Belmouhoub,

Tacherfiout,

Boukhalfa

et al. 2022

Int. J. Plant Based Pharm.

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The use of medicinal plants for the prevention and treatment of several diseases, particularly diabetes, remains the remedy and the sustainable source for many diseases. This survey was conducted out in Bejaia province in the center of Algeria to invent the main plants used in folk medicine to treat diabetes mellitus, their availability in this region, and the mode of their use. This study was carried out in 2019 in several municipalities of the study area. Ethnobotanical information was obtained using a questionnaire through direct interviews with 323 people with diabetes. Among people with diabetes interviewed, 82% present type 2 diabetes, from which more than 60% of them use medicinal plants against 36.84% only in type 1 diabetics. Diabetes affected age groups differently; the age range most affected was 61-80 years (43.96%). A total of 43 plant species belonging to 25 families were identified and listed in this study. The most frequent species used by patients are Artemisia herba-alba (34.42%), Olea europaea (13.66%), and Ajuga iva (11.47%). The part of the plant used depends on the plant; the aerial part was the more used (40.9%), followed by leaves (25%) and fruits (13.63%). The other parts, such as seed, root, flower, bark, bulb, epicarp, and rhizome, were used with low frequencies. It was also interesting to indicate that decoction and infusion were the systematic preparation methods compared to others (maceration, cooking with food, and fresh). The present study clearly showed that phytotherapy is widely adopted by center Algerian society, and there is a huge diversity of medicinal plants used for the complementary treatment of diabetes. Moreover, this investigation provides researchers with important information that can be exploited to develop anti-diabetic remedies.

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Limonene and ursolic acid in the treatment of diabetes

Bacanlı

2020

Diabetes

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Effect of hydroalcohol extract of lemon (<i>Citrus limon</i>) peel on a rat model of type 2 diabetes

Abstract: Purpose: To determine the effect of the hydroalcohol extract of lemon peel (LP) on a rat model of type 2 diabetes (T2D

Cited by 7 publications

References 15 publications

Chemical composition of essential oils of Citrus limon peel from three Moroccan regions and their antioxidant, anti-inflammatory, antidiabetic and dermatoprotective properties

Chemical composition of essential oils of Citrus limon peel from three Moroccan regions and their antioxidant, anti-inflammatory, antidiabetic and dermatoprotective properties

Traditional medicinal plants used in the treatment of diabetes: Ethnobotanical and ethnopharmacological studies and mechanisms of action

Limonene and ursolic acid in the treatment of diabetes

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