Effect of hydrophilic–hydrophobic balance on biocompatibility of poly(methyl methacrylate) (PMMA)–hydroxyapatite (HA) composites

Tihan, Teodora Gratiela; Ioniță, Daniela; Popescu, Roxana; Iordǎchescu, Dana

doi:10.1016/j.matchemphys.2009.03.019

Cited by 104 publications

(48 citation statements)

References 28 publications

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“…22 PMMA bone cements are highly hydrophobic, a limited hydration capacity of about 2-3 wt % and higher water contact angle have been reported for joint replacement bone cements. 23 Radiopacifier content of verterbroplasty bone cement can approach 36 wt % to improve X-ray contrast about 3-3.6 times higher than their joint replacement counterparts.…”

Section: Hydrophobicitymentioning

confidence: 99%

In Vitro characterization of low modulus linoleic acid coated strontium‐substituted hydroxyapatite containing PMMA bone cement

et al. 2010

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Poly (methyl methacrylate) (PMMA) bone cement is widely used in vertebral body augmentation procedures such as vertebroplasty and balloon kyphoplasty. Filling high modulus PMMA increases the modulus of filled verterbra, increasing the risk of fracture in the adjacent vertebra. On the other hand, in porous PMMA bone cements, wear particle generation and deterioration of mechanical performance are the major drawbacks. This study adopts a new approach by utilizing linoleic acid coated strontium substituted hydroxyapatite nanoparticle (Sr-5 HA) and linoleic acid as plasticizer reducing bone cement's modulus with minimal impact on its strength. We determined the compressive strength (UCS) and modulus (Ec), hydrophobicity, injectability, in vitro bioactivity and biocompatibility of this bone cement at different filler and linoleic acid loading. At 20 wt % Sr5-HA incorporation, UCS and Ec were reduced from 63 ± 2 MPa, 2142 ± 129 MPa to 58 ± 2 MPa, 1785 ± 64 MPa, respectively. UCS and Ec were further reduced to 49 ± 2 MPa and 774 ± 70 MPa respectively when 15 v/v of linoleic acid was incorporated. After 7 days of incubation, pre-osteoblast cells (MC3T3-E1) attached on 20 wt % Sr5-HA and 20 wt % Sr5-HA with 15 v/v of linoleic acid group were higher (3.73 ± 0.01 x 10⁴, 2.27 ± 0.02 x 10⁴) than their PMMA counterpart (1.83 ± 0.04 x 10⁴). Incorporation of Sr5-HA with linoleic acid in monomer phase is more effective in reducing the bone cement's stiffness than Sr5-HA alone. Combination of low stiffness and high mechanical strength gives the novel bone cement the potential for use in vertebroplasty cement applications.

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Section: Hydrophobicitymentioning

confidence: 99%

In Vitro characterization of low modulus linoleic acid coated strontium‐substituted hydroxyapatite containing PMMA bone cement

et al. 2010

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“…It is still widely used as such because of these desirable attributes and handling characteristics: low cost, easy handling and processing, easy to polish and repair, and excellent esthetics and biocompatibility in the oral environment 2) . However, PMMA denture base material is not ideal in every respect and has disadvantages such as insufficient surface hardness, poor wear resistance, and low flexural strength 3) , the latter being the common cause of fracture of denture base resins 4) .…”

Section: Introductionmentioning

confidence: 99%

Mechanical and thermal properties of denture PMMA reinforced with silanized aluminum borate whiskers

Zhang

Zhu

et al. 2012

Dent. Mater. J.

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The aim of this study was to investigate the mechanical and thermal properties of denture polymethyl methacrylate (PMMA) reinforced with aluminum borate whiskers (ABWs). To improve bonding between ABWs and PMMA matrix, the surface of ABWs was modified with a silane coupling agent. Varied contents of silanized ABWs -ranging between 1 and 20 wt%-were mixed into the PMMA resin matrix to prepare ABW/PMMA composites, which were subjected to three-point bending test, Vickers hardness test, and thermal analysis. Silanized ABWs improved the flexural strength, surface hardness, and thermal stability of PMMA. Optimal amount of ABWs in the PMMA matrix was 5 wt%, which provided the ABW/PMMA with maximum reinforcement.

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“…The addition of HA to system generated an increase of hydroxyl groups and surface tension suitable for hydrophilic; however, the combination between HA without surface‐grafted by IPS and matrix was poor, which had n rough surface, resulting an increase in WCA. It was believed that the increased hydrophilicity of the composite filled with HA‐ g ‐Si could enhance the biocompatibility of the material surface with respect to human cells [38].…”

Section: Resultsmentioning

confidence: 99%

Light‐curable composite of siloxane/hydroxyapatite prepared by the sol–gel process for bone defect treatment

Chang

et al. 2011

Polymer Composites

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The light‐curable composite of siloxane/hydroxyapatite (HA) had been successfully achieved by photopolymerization of a kind of gel combined tetraethoxyorthosilicate (TEOS) and 3‐methacryloxypropyltrimethoxysilane (MAPS) with siloxane‐modified nano‐HA (HA‐g‐Si). HA‐g‐Si was prepared by grafting reaction of 3‐isocyanatopropyltrimethoxysilane (IPS) onto the surface of HA. Then, TEOS and MAPS were mixed as precursor, and photoinitiator 2‐hydroxy‐4′‐(2‐hydroxyethoxy)‐2‐methylpropiophenone (Irgacure 2959) and as‐prepared HA‐g‐Si were added into the precursor to form a homogenous and sticky gel. The movable gel that could be cured with UV light resulted in various sharp immovable composites of siloxane/HA in different mold. The HA, HA‐g‐Si nanoparticles, and composites were analyzed by Fourier transformed infrared spectroscopy, X‐ray photoelectron spectroscopy, X‐ray diffraction, thermogravimetric analysis, transmission electron microscopy, scanning electron microscopy, mechanical testing, and water contact angles. It could be a promising bone repairing material for orthopedic application. POLYM. COMPOS., © 2011 Society of Plastics Engineers.

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Effect of hydrophilic–hydrophobic balance on biocompatibility of poly(methyl methacrylate) (PMMA)–hydroxyapatite (HA) composites

Cited by 104 publications

References 28 publications

In Vitro characterization of low modulus linoleic acid coated strontium‐substituted hydroxyapatite containing PMMA bone cement

In Vitro characterization of low modulus linoleic acid coated strontium‐substituted hydroxyapatite containing PMMA bone cement

Mechanical and thermal properties of denture PMMA reinforced with silanized aluminum borate whiskers

Light‐curable composite of siloxane/hydroxyapatite prepared by the sol–gel process for bone defect treatment

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