Effect of hydrophobic moiety on the gelation behavior of pyridyl boronic acid-derived amphiphiles: application in entrapment and release of vitamin B12

Roy, Sumita; Maiti, Monali; Das, Siddhartha; Roy, Aparna

doi:10.1007/s11696-019-00865-z

Cited by 3 publications

(3 citation statements)

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“…This behavior can be the result of a deficiency of sustaining a proper hydrophilic–lipophilic balance. , For stable gel formation, proper balance between the solubilization and precipitation of the gelator molecule in a specific solvent is required . It has also been reported that the incorporation of ether linkage in the hydrophobic tail reduced the gelation ability …”

Section: Resultsmentioning

confidence: 99%

“…40 It has also been reported that the incorporation of ether linkage in the hydrophobic tail reduced the gelation ability. 23 In the monocoupled series, 12M glycolipid exhibited gelation in aliphatic and aromatic hydrocarbons like pentane, hexane, heptane, cyclohexane, benzene, xylene, and toluene in the presence of a small quantity of water but became soluble on increasing the solvent polarity. In cases of 16M and 22M glycolipids, they either were insoluble or formed an emulsion in nonpolar organic solvents and soluble in more polar organic solvents.…”

Section: Resultsmentioning

confidence: 99%

“…Gels are proven to be excellent carrier systems in the biomedical field. Encapsulation of bioactives inside the self-assembled gel network of amphiphilic molecules has been extensively studied. , Enzyme- and pH-responsive drug release behavior of supramolecular phenoxy-alkyl maleate-based hydrogels was studied by encapsulating the hydrophobic curcumin drug inside the gel network . Supramolecular hydrogel-based drug delivery systems have found medical use with therapeutic outcomes.…”

Section: Introductionmentioning

confidence: 99%

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Supramolecular Glycolipid-Based Hydro-/Organogels with Enzymatic Bioactive Release Ability by Tuning the Chain Length and Headgroup Size

Holey

Sekhar

Swain

et al. 2022

ACS Biomater. Sci. Eng.

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Designing of supramolecular hydro-/organogels having desired properties, biocompatibility, and stimuli responsiveness is a challenging task. Herein, the gelation ability of amphiphilic glycolipid-based gelators in a wide range of solvents is explored. The structure–function relationship was established by varying the chain length and polar headgroup size of amphiphilic gelators. The prepared hydro-/organogels were characterized by employing several techniques such as differential scanning calorimetry (DSC), rheology, field emission scanning electron microscopy (FE-SEM), high-resolution transmission electron microscopy (HR-TEM), X-ray diffraction (XRD), etc. The thermal stability of hydro-/organogels increased with an increase in chain length. Rheological analysis depicted that variation in chain length and headgroup size of amphiphilic gelators significantly affected the gel strength and stability. The self-assembled morphology of hydro-/organogel samples revealed the compact entangled fibrillar network structures. After comparing the energy-minimized molecular length with the d-spacing value obtained by XRD, interdigitated bilayer packing in the gel network was established. The bioactive encapsulation and enzymatic release study of hydro-/organogels portrayed their potential application in the biomedical field. To our delight, glycolipid 16M (C16 chain length) formed a molecular hydrogel with injectable and thixotropic behaviors. High critical strain value, thixotropy, injectability, thermoreversibility, and faster bioactive release for the 16M-W hydrogel proved crucial to predict its future applications. Overall, glycolipid amphiphiles designed by upholding proper hydrophilic–lipophilic balance can form multifunctional supramolecular hydrogels with excellent implementation in the drug delivery system.

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