Conventional dental cements are based on mechanically locking the restoration to the tooth, while the main task is to fill the gap between the tooth and restoration [1,2]. One of the epochal events in dentistry in the last 30 years was the adhesive cementation of tooth-colored restorations prepared using minimally invasive techniques [3]. Adhesive resin cements are used for the cementation of many restorations such as inlays, onlays, fiber-supported bridges, crowns, and laminate veneers [4]. While the content of the majority of resin cements is similar to that of dental composites, commercially available products have various physical and mechanical differences owing to their type, size, and amount of diluent monomer or filler particles [4,5].According to the matrix formation mechanism, adhesive cements are classified as follows: (1) light-activated curing, (2) self-or auto-curing, and (3) dual curing [1]. Compared with conventional cements, adhesive cements have improved adhesion and mechanical properties [6,7]. However, polymerization shrinkage of these ce-ments causes marginal integrity deterioration and micro-leakage of the restorations, which could significantly shorten the lifetime of the restorations [6,8,9]. One method of ensuring the longevity of dental restorations is to provide a tight connection between the tooth and restoration and create an environment that prevents bacterial adhesion [10]. Few clinical studies have been conducted on resin cements to evaluate the survival and success rates of restorations. Moreover, studies have also mentioned that self-adhesive resin cements have similar survival rates to zinc phosphate cements, i.e., a survival rate of 97.6%, even in the cementation of metal-ceramic crowns. However, it has also been reported that the survival rate of partial all-ceramic crowns cemented with self-adhesive resin cements is lower than that of conventional resin cements [11][12][13].For this aim, bioactive materials that can slowly release ions to form bonds between tissues and materials can be added to self-adhesive resin cements [10,14]. Among the diverse spectrum of materials that exhibit bioactive properties (bioactive glasses (BAGs), hydroxyapatites, calcium phosphates, and calcium aluminates), BAGs are biocompatible, osteoconductive, and osteoinductive calcium-silicate-based biomaterials [10,15,16]. The first BAG, developed in 1969 by Prof. Larry Hench, could form bonds with soft and hard tissues such as bone. BAG, known as 45S5 today, consists of 46.1 mol% SiO 2 , 26.9 mol% CaO, 24.4 mol% Na 2 O, and 2.6 mol% P 2 O 5 and precipitates hydroxyapatite in aqueous solutions [16][17][18].