Effect of hyperbaric oxygen on survival of composite grafts in rats

Fodor, Lucian; Ramon, Yitzchak; Meilik, Beny; Carmi, Nurit; Shoshani, Oren; Ullmann, Yehuda

doi:10.1080/02844310600907868

Cited by 13 publications

(7 citation statements)

References 21 publications

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“…The experimental evidence supporting the use of HBO in composite grafts was shown in the rat model by several authors. 14,15 Survival advantages in the rabbit model have also been reported by multiple authors. 16–19 The anecdotal clinical evidence supporting the use of HBO in composite grafts has also been reported by multiple authors.…”

Section: Discussionmentioning

confidence: 52%

Successful Bilateral Composite Ear Reattachment

Kalus

2014

Plastic and Reconstructive Surgery Global Open

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Summary:A successful bilateral ear composite graft nonmicrosurgical reattachment is presented. In cases where suitable vessels are unavailable for microsurgical revascularization, the reconstructive challenge can be formidable for salvaging the unique anatomic and aesthetic structure of the ear. The case is presented of an 18-year-old woman who was a victim of an assault wherein both of her ears were intentionally amputated by her attacker. She underwent successful surgical reattachment followed by a postoperative regimen of hyperbaric oxygen, cooling, and meticulous wound care. The patient achieved 100% survival of her left ear graft and 95% survival of her right ear graft. Clinical photographs at 18 months are presented, along with a discussion of the possible implications for other reconstructive applications.

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Section: Discussionmentioning

confidence: 52%

Successful Bilateral Composite Ear Reattachment

Kalus

2014

Plastic and Reconstructive Surgery Global Open

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“…Improving the survival rate of skin flaps is one of the main aims in plastic surgery. A number of studies have demonstrated the beneficial effects of HBO treatment on improving survival of compromised skin grafts and flaps, including the venous flap, the tubed pedicle flap, the composite graft and the random pattern skin flap (10,11,(13)(14)(15). However, the detailed mechanisms involved are not fully understood.…”

Section: Discussionmentioning

confidence: 99%

Effects of stromal cell derived factor-1 and CXCR4 on the promotion of neovascularization by hyperbaric oxygen treatment in skin flaps

Liu

Liang

Yang

et al. 2013

Molecular Medicine Reports

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Hyperbaric oxygen (HBO) is known to increase the survival of skin flaps by promoting neovascularization; however, the detailed mechanisms involved are not fully understood. In the present study, we aimed to characterize the effects of HBO treatment on neovascularization and skin flap survival. We also analyzed the mechanisms associated with the expression of angiogenic molecules, such as stromal cell derived factor-1 (SDF‑1) and its specific receptor CXCR4, to assess the effects of SDF-1 and CXCR4 on the promotion of neovascularization by HBO treatment in skin flaps. The epigastric pedicle skin flap model was established in rats that were randomly divided into the following groups: i) sham‑operated (SH group); ii) ischemia followed by reperfusion and analysis on the third and fifth day (IR3d and IR5d groups, respectively) postoperatively; iii) ischemia followed by reperfusion, HBO treatment and analysis on the third and fifth day (HBO3d and HBO5d groups, respectively) postoperatively. In the two HBO groups, animals received 1 h of HBO treatment in a 2.0 ATA chamber with 100% O2 twice per day for 3 days and then daily for 2 consecutive days following surgery. On the postoperative third and fifth day, skin ﬂap survival measurement, histological analysis, immunohistochemical staining and western blotting for SDF‑1 and CXCR4 expression, were performed. Compared with those of the IR groups, skin flap survival, microvessel density (MVD) and expression of SDF‑1 and CXCR4 proteins were significantly increased in the HBO groups. Pearson's correlation analysis demonstrated a positive correlation between MVD and the high expression of SDF‑1 and CXCR4 following HBO treatment. Results of this study suggested that the effects of HBO treatment in promoting neovascularization may be explained by the upregulation of SDF‑1 and CXCR4 expression in the skin flaps of rats.

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“…For example, Fodor et al found that the survival of composite grafts in rats improved after being placed in a hyperbaric chamber for 90 minutes daily for two weeks. This improvement was especially prominent on the inner surface of the graft [ 12 ]. In the same way, HBOT proved to promote faster healing and epithelialization of second-degree wounds in the experiments of Korn done on guinea pigs [ 13 ].…”

Section: Reviewmentioning

confidence: 99%

Therapeutic Outcome of Burn Patients Treated With Hyperbaric Oxygen

Alyafi¹,

Al-Marzouki²,

Hassani³

2021

Cureus

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Amongst various interventions for burns and inhalation injuries, hyperbaric oxygen therapy (HBOT) has recently been widely integrated as an adjunctive management of care due to its therapeutic properties in reducing tissue hypoxia, pathological inflammation, and augmenting neovascularization. However, the limitation of human clinical trials and data undermines its efficacy to be implemented as an adjunctive therapeutic modality in burns. The purpose of the literature review is to determine the efficacy of HBOT as an adjunct to standard management in burns. A review of the literature was done by searching PubMed, Cochrane, Medline, EMBASE, and Google Scholar for papers addressing the comparison of therapeutic outcomes between HBOT and non-HBOT in burns. Current research findings are conflicting, and the use of HBOT as an adjunct in burns management is still controversial. Therefore there is still a need for more data and research on the therapeutic benefits of HBOT in burn management.

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Effect of hyperbaric oxygen on survival of composite grafts in rats

Cited by 13 publications

References 21 publications

Successful Bilateral Composite Ear Reattachment

Successful Bilateral Composite Ear Reattachment

Effects of stromal cell derived factor-1 and CXCR4 on the promotion of neovascularization by hyperbaric oxygen treatment in skin flaps

Therapeutic Outcome of Burn Patients Treated With Hyperbaric Oxygen

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