Effect of hypercholesterolemia alone or combined with hypertension on the degree of coronary artery stenosis in patients with coronary heart disease angina pectoris

Abstract

Background: Coronary heart disease (CHD) is the leading cause of death globally. Angina pectoris is closely associated with coronary artery insufficiency, which seriously affects the quality of life and work of patients. Hypercholesterolemia and hypertension (HTN) are risk factors for CHD angina pectoris. The correlation between hypercholesterolemia with or without HTN and the severity of coronary arteries has not been clarified. Objective: To explore the correlation between hypercholesterolemia and the degree of coronary artery stenosis (CAS) of CHD angina pectoris, and to further research the influence of HTN on total cholesterol level and CAS, so as to provide guidance for clinical prevention and treatment. Methods: A multicenter, retrospective clinical study was conducted in the medical records management system of 6 hospitals in Tianjin. Patients who were suffered from CHD angina pectoris and aged from 35 to 75 years old are involved. They hospitalized in the Department of Cardiology between September 1, 2014, and September 1, 2019, and underwent coronary angiography. We divide patients into 3 groups based on the total cholesterol level, the degree of CAS is evaluated by Gensini score, and further divide them into 6 subgroups based on with or without HTN. Collect and analyze the demographics, laboratory information, clinical outcome data, and coronary angiographic data of patients. Conclusion: Through clinical research data, the study will help to provide guidance for the prevention and treatment of CHD angina pectoris complicated with diseases and promote further research.

Study of Scraping with Copper Stone Based on Theory of Midnight-Noon Ebb-Flow in Angina Pectoris with Coronary Heart Disease of Qi Stagnation and Blood Stasis

“…AP is one of the main types of CHD with irregular episodes and pain radiating to the shoulder and neck during attacks. Factors such as overwork, mood disorders, and climate change are potential triggers for the development of the disease, and if not treated in a timely manner, there is a high risk of developing acute myocardial infarction which may lead to a significant increase in the risk of death [ 10 , 11 ]. Pharmacological treatment is a conventional therapy in Western medicine, which mainly focuses on 3 aspects: dilating diseased blood vessels, improving atherosclerosis, and lowering blood pressure, with the purpose of reducing myocardial oxygen consumption, delaying atherosclerotic lesions, improving myocardial blood supply, and thus relieving angina symptoms and reducing mortality [ 12 ].…”

Correlation between the triglyceride-to-high-density lipoprotein cholesterol ratio and other unconventional lipid parameters with the risk of prediabetes and Type 2 diabetes in patients with coronary heart disease: a RCSCD-TCM study in China

“…Before conducting statistical analysis, we invited statistical analysts to develop a plan, specify detailed steps, and carefully check the collected data. All statistical analysis processes are programmed and archived for future reference [21].…”

Effects of Different Doses of Nitroglycerin Combined With Atenolol on Plasma Viscosity and Inflammatory Response in Patients With Angina Pectoris

“…Most people usually have no symptoms, but there are often signs of myocardial ischemia, such as feeling precordial discomfort, or fatigue symptoms, although the symptoms are very mild, but if ECG examination is performed in time, myocardial ischemia will be found and can be prevented as soon as possible. Most of these are latent coronary heart diseases [7,8]. Some patients have obvious symptoms, often appear retrosternal or left heart pain, mostly transient, short duration, if the acute attack is precordial severe pain, sweating, lips cyanosis and other symptoms, it indicates myocardial infarction, and it should be treated by emergency treatment before rescue by the hospital.…”