Effect of hyperemesis gravidarum on gestational diabetes mellitus screening

Ohara, Rena; Obata‐Yasuoka, Mana; Abe, Kiyoshi; Yagi, Hiroya; Hamada, Hiromi; Yoshikawa, Hiroyuki

doi:10.1016/j.ijgo.2015.06.061

Cited by 9 publications

(12 citation statements)

References 20 publications

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“…Between the years 2000 and 2016, 48 articles were published with a total sample of 3,594,803 pregnant women (range: 1038–1,824,913) in 7 countries. Of the 48 studies, 21 were conducted in China [ 41 – 43 , 45 , 48 – 64 ], 8 in the Republic of Korea [ 65 , 68 , 70 – 72 , 74 , 75 , 77 ], 6 in Thailand [ 37 , 46 , 79 – 81 , 83 ], five in Japan [ 39 , 47 , 73 , 76 , 78 ], five in Taiwan (China) [ 38 , 44 , 66 , 67 , 69 ], one in Malaysia [ 82 ], one in Singapore [ 40 ], and one in Vietnam [ 36 ]. Two-thirds of the studies ( n = 32) used a two-step screening procedure, that is, women underwent a 1-hour glucose challenge test (GCT) and a 3-hour glucose tolerance test (GTT) if GCT were abnormal.…”

Section: Resultsmentioning

confidence: 99%

Prevalence of Gestational Diabetes Mellitus in Eastern and Southeastern Asia: A Systematic Review and Meta-Analysis

Nguyen

Pham

Binns

et al. 2018

Journal of Diabetes Research

199

148

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Aim To review the prevalence of gestational diabetes mellitus (GDM) in Eastern and Southeastern Asia. Methods We systematically searched for observational studies on GDM prevalence from January 2000 to December 2016. Inclusion criteria were original English papers, with full texts published in peer-reviewed journals. The quality of included studies was evaluated using the guidelines of the National Health and Medical Research Council, Australia. Fixed effects and random effects models were used to estimate the summary prevalence of GDM and the corresponding 95% confidence intervals (CI). Results A total of 4415 papers were screened, and 48 studies with 63 GDM prevalence observations were included in the final review. The pooled prevalence of GDM was 10.1% (95% CI: 6.5%–15.7%), despite substantial variations across nations. The prevalence of GDM in lower- or upper-middle income countries was about 64% higher than in their high-income counterparts. Moreover, the one-step screening method was twice more likely to be used in diagnosing GDM when compared to the two-step screening procedure. Conclusions The prevalence of GDM in Eastern and Southeastern Asia was high and varied among and within countries. There is a need for international uniformity in screening strategies and diagnostic criteria for GDM.

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Section: Resultsmentioning

confidence: 99%

Prevalence of Gestational Diabetes Mellitus in Eastern and Southeastern Asia: A Systematic Review and Meta-Analysis

Nguyen

Pham

Binns

et al. 2018

Journal of Diabetes Research

199

148

View full text Add to dashboard Cite

show abstract

“…Our results also raise the question whether there is a link between pregnancy‐related nausea and beta cell function, and whether GDF15 has a role in this. In severe hyperemesis, starvation might negatively affect glucose metabolism early in pregnancy, but by the second trimester there seems to be no difference in glucose tolerance 37 . Research on less severe emesis is lacking.…”

Section: Discussionmentioning

confidence: 99%

Growth‐differentiation‐factor 15 levels in obese and healthy pregnancies: Relation to insulin resistance and insulin secretory function

Andersson‐Hall

Joelsson

Svedin

et al. 2021

Clinical Endocrinology

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Objective/Aim Growth‐differentiation‐factor 15 (GDF15) has been suggested to improve or protect beta cell function. During pregnancy, beta cell numbers and function increase to overcome the natural rise in insulin resistance during gestation. In this study, we longitudinally measured serum GDF15 levels during and after pregnancy in women of normal weight (NW) and in women with obesity (OB) and explored associations between GDF15 and changes in beta cell function by homeostatic model assessment (HOMA). Methods The cohort participants were 38 NW (BMI 22.3 ± 1.7) and 35 OB (BMI 35.8 ± 4.2). Blood was sampled and body composition measured at each trimester (T1, T2, and T3) and at 6, 12 and 18 months postpartum. Fasting glucose, insulin and GDF15 were measured, and HOMA for insulin resistance (HOMA‐IR) and beta cell function (HOMA‐B) determined. Results GDF15 levels increased significantly each trimester and were ~200‐fold higher at T3 than in the nonpregnant postpartum state. GDF15 was higher in NW than OB during pregnancy, but was reversed after pregnancy with a significant interaction effect. GDF15 correlated inversely with BMI and fat‐free mass at T3. Low GDF15 was associated with lower incidence of nausea and with carrying a male foetus. The pregnancy induced increase in GDF15 associated with increased HOMA‐B in OB and with reduced fasting glucose in all women. Conclusion Large gestational upregulation of GDF15 levels may help increase insulin secretory function to overcome pregnancy‐induced insulin resistance.

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“…Patients with known diabetes mellitus, serious medical disorders including severe hypertensive disorders and chronic liver disease, or with hyperemesis gravidarum were excluded. This was done to avoid misclassification bias; hyperemesis gravidarum has been demonstrated to affect GDM screening rates . The ethics and research committee of the Mother and Child Hospital, Akure, approved the study and written informed consent was obtained from all participants.…”

Section: Methodsmentioning

confidence: 99%

Accuracy of 50‐g glucose challenge test to detect International Association of Diabetes and Pregnancy Study Groups criteria‐defined hyperglycemia

Olagbuji

Aderoba²,

Kayode

et al. 2017

Intl J Gynecology & Obste

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Effect of hyperemesis gravidarum on gestational diabetes mellitus screening

Abstract: Hyperemesis gravidarum affects the positive GDM screening rate in the first trimester.

Cited by 9 publications

References 20 publications

Prevalence of Gestational Diabetes Mellitus in Eastern and Southeastern Asia: A Systematic Review and Meta-Analysis

Prevalence of Gestational Diabetes Mellitus in Eastern and Southeastern Asia: A Systematic Review and Meta-Analysis

Growth‐differentiation‐factor 15 levels in obese and healthy pregnancies: Relation to insulin resistance and insulin secretory function

Accuracy of 50‐g glucose challenge test to detect International Association of Diabetes and Pregnancy Study Groups criteria‐defined hyperglycemia

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