Effect of hyperglycaemia on muscarinic <scp>M3</scp> receptor expression and secretory sensitivity to cholinergic receptor activation in islets

Hauge-Evans, Astrid C.; Reers, Christina; Kerby, Alan; Franklin, Zara J.; Amisten, Stefan; King, Aileen; Hassan, Zoheb; Flores, Angélica; Tippu, Z.; Persaud, Shanta J.; Jones, Peter M.

doi:10.1111/dom.12301

Cited by 13 publications

(12 citation statements)

References 48 publications

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“…Some researchers are of the view that hyperglycemia and diabetes caused by quetiapine therapy are primarily the result of M 3 receptor antagonism. 22 ) So it would appear that while norquetiapine is responsible for therapeutic effects it may also be to blame for quetiapine’s adverse effects.…”

Section: Main Subjectsmentioning

confidence: 99%

Pharmacotherapy of Bipolar Disorder with Quetiapine: A Recent Literature Review and an Update

Muneer

2015

Clin Psychopharmacol Neurosci

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Bipolar disorder is a chronic, recurrent condition with the usual onset during adolescence or early adulthood. In the Diagnostic and Statistical Manual of Mental Disorders 5th edition, it is conceptualized as a spectrum disorder usually associated with such comorbidities as anxiety disorders and substance use disorders. It is a relatively prevalent condition often complicated by mixed episodes, rapid cycling, subsyndromal symptoms, and treatment refractoriness. In spite of carrying substantial morbidity and mortality, effective treatments are few and far between and conventional mood stabilizers are often unsuccessful in controlling the various manifestations of the disorder. In this scenario, second generation antipsychotics are emerging as treatments with valid efficacy in all phases of bipolar disorder. Quetiapine is a versatile atypical antipsychotic which was first approved for the treatment of schizophrenia, but latter on the basis of controlled studies earned United States Food and Drug Administration's approval for acute as well as maintenance treatment of this difficult to treat condition. In this review, recently published studies in the last 10 years were examined to update the knowledge about the efficacy and safety of quetiapine in the treatment of bipolar disorder. The medication's clinical pharmacology was first considered followed by a literature review summarizing its uses in bipolar disorder. The conclusion was that quetiapine was efficacious in manic, mixed and depressive episodes and as a maintenance agent with a good tolerability profile.

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Section: Main Subjectsmentioning

confidence: 99%

Pharmacotherapy of Bipolar Disorder with Quetiapine: A Recent Literature Review and an Update

Muneer

2015

Clin Psychopharmacol Neurosci

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“…To determine the signalling cascades, islets were treated with various intracellular inhibitors, pertussis toxin (1 ng/mL), U73122 (5 μM), Go6983 (1 μM), gallein (10 μM) or MEK inhibitor U0126 (5 μM), in the absence or presence of cytokines. PKC was depleted using PMA (200 nM) for 21 hours prior to treatment with cytokines . TUNEL staining was used to localize the anti‐apoptotic effect of 1 nM [Leu 31 Pro 34 ]‐NPY on beta‐cells.…”

Section: Methodsmentioning

confidence: 99%

“…Mouse islets were isolated from male CD1 mice aged 8–12 weeks (Charles River Laboratories, Margate, UK) by collagenase digestion (1 mg/mL; type XI; Sigma‐Aldrich, Poole, UK) and separated on a histopaque gradient (Histopaque 1077; Sigma‐Aldrich) . Human islets were obtained from the pancreata of non‐diabetic heart‐beating donors with appropriate ethical approval .…”

Section: Methodsmentioning

confidence: 99%

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Islet neuropeptide Y receptors are functionally conserved and novel targets for the preservation of beta‐cell mass

Franklin

Tsakmaki

Pedro

et al. 2017

Diabetes Obesity Metabolism

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“…Interestingly, M3 receptor expression is down regulated by high glucose treatment in mouse and human islets, thus suggesting that impaired glucose sensing and insulin secretion observed in diabetes may also be due to alteration of paracrine signaling systems (Hauge‐Evans et al, ).…”

Section: Acetylcholinementioning

confidence: 99%

Neurotransmitters and Neuropeptides: New Players in the Control of Islet of Langerhans' Cell Mass and Function

Cairano

Moretti

Marciani

et al. 2015

Journal Cellular Physiology

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Islets of Langerhans control whole body glucose homeostasis, as they respond, releasing hormones, to changes in nutrient concentrations in the blood stream. The regulation of hormone secretion has been the focus of attention for a long time because it is related to many metabolic disorders, including diabetes mellitus. Endocrine cells of the islet use a sophisticate system of endocrine, paracrine and autocrine signals to synchronize their activities. These signals provide a fast and accurate control not only for hormone release but also for cell differentiation and survival, key aspects in islet physiology and pathology. Among the different categories of paracrine/autocrine signals, this review highlights the role of neurotransmitters and neuropeptides. In a manner similar to neurons, endocrine cells synthesize, accumulate, release neurotransmitters in the islet milieu, and possess receptors able to decode these signals. In this review, we provide a comprehensive description of neurotransmitter/neuropetide signaling pathways present within the islet. Then, we focus on evidence supporting the concept that neurotransmitters/neuropeptides and their receptors are interesting new targets to preserve β-cell function and mass. A greater understanding of how this network of signals works in physiological and pathological conditions would advance our knowledge of islet biology and physiology and uncover potentially new areas of pharmacological intervention. J. Cell. Physiol. 231: 756-767, 2016. © 2015 Wiley Periodicals, Inc.

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Effect of hyperglycaemia on muscarinic M3 receptor expression and secretory sensitivity to cholinergic receptor activation in islets

Cited by 13 publications

References 48 publications

Pharmacotherapy of Bipolar Disorder with Quetiapine: A Recent Literature Review and an Update

Pharmacotherapy of Bipolar Disorder with Quetiapine: A Recent Literature Review and an Update

Islet neuropeptide Y receptors are functionally conserved and novel targets for the preservation of beta‐cell mass

Neurotransmitters and Neuropeptides: New Players in the Control of Islet of Langerhans' Cell Mass and Function

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