Effect of Hyperinsulinemia on the Development of Blood Coagulation in the Lamb Fetus

Kisker, C. Thomas

doi:10.1203/00006450-199508000-00006

Cited by 3 publications

(2 citation statements)

References 6 publications

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“…A hypercoagulable state can be induced in sheep experimentally with infusion of endotoxin 25 after severe trauma, 26 in fetal lambs with infusion of insulin, 27 and naturally after viral infection. [28][29][30] Thus a potential weakness of this study is that an unrecognized hypercoagulable state, if present in some of the animals, could markedly bias the TFSA results, depending on the randomization schedule.…”

Section: Discussionmentioning

confidence: 99%

Nitric oxide–releasing biopolymers inhibit thrombus formation in a sheep model of arteriovenous bridge grafts

Fleser

Nuthakki

Malinzak

et al. 2004

Journal of Vascular Surgery

105

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Section: Discussionmentioning

confidence: 99%

Nitric oxide–releasing biopolymers inhibit thrombus formation in a sheep model of arteriovenous bridge grafts

Fleser

Nuthakki

Malinzak

et al. 2004

Journal of Vascular Surgery

105

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“…77 Fetal lambs made hyperglycemic also showed decreased protein C. 77 When one fetal lamb ovine twin was made hyperinsulinemic and hypoglycemic, levels of protein C decreased while levels of factors I, V, VII, and XI increased in comparison with the control twin. 78 Pharmacokinetic studies of ovine antithrombin and protein C showed increased volume of distribution and shortened half-life of both proteins in the fetal lamb compared with the ewe indicating more rapid turnover. 79 Thus, the neonatal hemostasis system exhibits differential effects of regulation of expression, protein kinetics, and impact of maternal conditions.…”

Section: Hemostasis Development In the Fetusmentioning

confidence: 97%

Hemostasis in the Pregnant Woman, the Placenta, the Fetus, and the Newborn Infant

Warren

Moyer

Manco‐Johnson

2023

Semin Thromb Hemost

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The hemostasis system is composed of procoagulant, anticoagulant, and fibrinolytic proteins that interact with endothelial and blood cells and with each other in a complex system of checks and balances to maintain blood flow while preventing both hemorrhage and thrombosis. Pregnancy is a unique physiological state in which biological alterations predispose both mother and fetus to both bleeding and clotting. The placenta is a vascular interface for maternal and fetal blood exchange which predisposes the mother to hemorrhage. Maternal hemostasis presents a compensatory hypercoagulability including elevated factor VIII, von Willebrand factor, fibrinogen and thrombin generation, decreased thrombin regulation with resistance to activated protein C and decreased free protein S, and decreased fibrinolysis with increased plasminogen activator inhibitors. The placental vascular surface is of fetal trophoblastic origin that derives many characteristics of endothelium but differs in that tissue factor is constitutively expressed. Ontogeny of fetal hemostasis is characteristic. Platelets, von Willebrand factor, factor VIII, and fibrinogen are expressed and mature early in gestation, while vitamin K–dependent and contact factors exhibit delayed development. The fetal hemostatic system has a decreased capacity to generate or regulate thrombin, resulting in a fragile balance with little capacity to compensate under stress conditions, particularly in the infant born prematurely. Dysfunction of the maternal/placental/fetal unit gives rise to gestational disorders including preeclampsia, fetal growth restriction, placental abruption, and premature delivery. Knowledge of normal hemostasis levels and function are critical to evaluate bleeding or clotting syndromes in the pregnant woman and her fetus or newborn infant.

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Developmental hemostasis II

Manco‐Johnson¹

2014

Pediatric Thrombotic Disorders

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Effect of Hyperinsulinemia on the Development of Blood Coagulation in the Lamb Fetus

Cited by 3 publications

References 6 publications

Nitric oxide–releasing biopolymers inhibit thrombus formation in a sheep model of arteriovenous bridge grafts

Nitric oxide–releasing biopolymers inhibit thrombus formation in a sheep model of arteriovenous bridge grafts

Hemostasis in the Pregnant Woman, the Placenta, the Fetus, and the Newborn Infant

Developmental hemostasis II

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