Effect of hyperlipidemic serum and irradiation on wound healing in primary quiescent cultures of vascular cells

Fischer-Dzoga, Katti; Dimitrievich, George S.; Schaffner, Thomas

doi:10.1016/0014-4800(90)90053-g

Cited by 21 publications

(7 citation statements)

References 33 publications

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“…It is less likely that radiation reduced SMC hyperplasia by inhibiting migration from the media to the intima, since migration of SMCs in vitro was not inhibited by external radiation. 37 Nevertheless, SMCs may respond differently in vivo because of local effects of chemotactic factors. 4344 We believe that gamma irradiation causes a reduction in neointimal proliferation by interfering with DNA synthesis and repair in actively dividing SMCs.…”

Section: Discussionmentioning

confidence: 99%

Gamma irradiation inhibits neointimal hyperplasia in rats after arterial injury.

Shimotakahara

Mayberg

1994

Stroke

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Background and Purpose Restenosis complicates a significant proportion of endovascular and open vascular procedures such as carotid endarterectomy. In contrast to the primary atheroma, restenosis is characterized by intimal hyperplasia of vascular smooth muscle cells. We hypothesized that gamma radiation would reduce restenosis by limiting intimal hyperplasia after arterial injury.Methods To demonstrate the effect of gamma radiation on smooth muscle hyperplasia in vivo, a standardized bilateral carotid balloon catheter arterial injury was produced in 37 rats. A single dose of 750, 1500, or 2250 cGy (lcGy=l rad) gamma radiation was delivered to the right carotid artery at either 1 or 2 days after injury; the shielded contralateral carotid artery served as matched control. At 21 days after injury, vessels were perfusion-fixed in situ, and cross-sectional area of neointima was determined from axial sections using image analysis.

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Section: Discussionmentioning

confidence: 99%

Gamma irradiation inhibits neointimal hyperplasia in rats after arterial injury.

Shimotakahara

Mayberg

1994

Stroke

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“…Radiation reliably inhibits cell proliferation in a dose-dependent manner as has been postulated by several authors [5,7,20,33]. However, the results concerning the effects of radiation on cell migration are equivocal and partially contradictory ranging from total inhibition to increase of the migratory activity [11,12,18,19]. One reason for those contradictions might be the use of different models and different endpoints in the cited studies.…”

Section: Discussionmentioning

confidence: 51%

Früheffekte einer Rhenium-188-Behandlung auf Proliferation, Migration und Matrixsynthese humaner aortaler glatter Muskelzellen in vitro

Kehlbach¹,

Dittmann

Schmid³

et al. 2006

Strahlenther Onkol

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“…[55][56][57][58][59][60][61] At higher doses, direct cell killing occurs from extensive ionization damage. Low-dose ionizing radiation has been shown to inhibit thymidine uptake and collagen synthesis by cultured fibroblasts.…”

Section: Radiobiology Of the Arterial Wallmentioning

confidence: 99%

<b>Irradiation and Postangioplasty Restenosis</b>

et al. 2000

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SUMMARYOne of the most intriguing developments in recent years towards prevention of restenosis after angioplasty is the use of ionizing radiation. The background for the use of radiation treatment for this application is sound, since radiation is used not only to treat malignant cancerous growths but also is used for treatment of benign hyperplastic disorders such as post-surgical keloid formation and recurrence of pterygium after surgical removal. Restenosis can be considered a form of overexuberant wound healing triggered by angioplasty. Ionizing radiation inhibits serum-stimulated proliferation of many cell types including fibroblasts and smooth muscle cells in vitro and also suppresses the synthesis of collagen by cultured fibroblasts. Liermann who showed inhibition of post-stent restenosis first used ionizing radiation for restenosis prevention clinically in iliac and iliofemoral arteries. Subsequently, extensive animal studies in various restenosis models have shown a profound inhibitory effect of catheter-based radiation (endovascular brachytherapy) on neointima formation and overall vessel shrinkage (negative remodeling). 1) performed the first coronary balloon angioplasty. After more than 20 years, percutaneous transluminal coronary angioplasty (PTCA) is now widely accepted as an effective therapy for selected patients with symptomatic coronary artery disease. However, the over-compensatory wound healing response to angioplasty causing restenosis significantly limits the long-

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Effect of hyperlipidemic serum and irradiation on wound healing in primary quiescent cultures of vascular cells

Cited by 21 publications

References 33 publications

Gamma irradiation inhibits neointimal hyperplasia in rats after arterial injury.

Gamma irradiation inhibits neointimal hyperplasia in rats after arterial injury.

Früheffekte einer Rhenium-188-Behandlung auf Proliferation, Migration und Matrixsynthese humaner aortaler glatter Muskelzellen in vitro

<b>Irradiation and Postangioplasty Restenosis</b>

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