Effect of Hyperoxia on Neurogenic Plasma Protein Extravasation in the Rat Dura Mater

Schuh‐Hofer, Sigrid; Siekmann, Wiebke; Offenhauser, Nikolas; Reuter, Uwe; Arnold, G.

doi:10.1111/j.1526-4610.2006.00447.x

Cited by 27 publications

(22 citation statements)

References 24 publications

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“…In the next attack, which started 40 minutes later, pain and CA ceased nearly simultaneously thanks to continuous oxygen supply. A study by Schuh‐Hofer et al showed hyperoxia to have an effect on neurogenic plasma protein extravasations, but not normoxia 9 . Similar results were shown in Goadsby's work based on treatment with hyperoxia and the interaction of hyperoxia and neuropeptide release 10 .…”

Section: Discussionsupporting

confidence: 55%

Oxygen Therapy Influences Episodic Cluster Headache and Related Cutaneous Brush and Cold Allodynia

Huber

Lampl

2009

Headache

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Cluster headache (CH) is characterized by a series of sudden attacks of short‐lasting severe headache pain with ipsilateral autonomic features, including lacrimation, rhinorrhea, localized sweating, eyelid edema, and partial or complete Horner's syndrome. Just like in migraine, brush allodynia has been described for CH and for short lasting unilateral neuralgiform headache with conjunctival injection and tearing (SUNCT) syndrome. Administration of normobaric oxygen is part of the standard therapy for CH attacks. Here, we describe a young male with a first CH attack and the influence of oxygen on pain and concomitant cutaneous allodynia.

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Section: Discussionsupporting

confidence: 55%

Oxygen Therapy Influences Episodic Cluster Headache and Related Cutaneous Brush and Cold Allodynia

Huber

Lampl

2009

Headache

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“…These observations suggest that the clinical implications of allodynia in these two primary headache disorders may differ. High-flow oxygen is also generally effective in CH, and hyperoxia can affect the extravasation of plasma proteins and decrease levels of calcitonin gene-related peptide [22]. …”

Section: Discussionmentioning

confidence: 99%

Dynamic mechanical (brush) allodynia in cluster headache: a prevalence study in a tertiary headache clinic

2009

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Cutaneous allodynia (CA) has been described in migraine and has been related to treatment failure. There are little data about the incidence of CA in other primary headache syndromes such as cluster headache (CH). The objectives of this study are to evaluate the prevalence of dynamic mechanical (brush) allodynia (BA) in CH patients attending a tertiary headache clinic, and to assess its relation to disease characteristics. Adult patients with episodic or chronic CH were recruited. We obtained demographic data and data on disease characteristics through a structured questionnaire, and tested the patients for brush allodynia BA by applying a 4 × 4 gauze pad over the V1, C2/C3 and C8 skin areas bilaterally. The prevalence of allodynia in the entire study population and in the different sub-groups was calculated. We also examined the association between CA and demographic parameters, and its association with disease characteristics. Forty-one patients were recruited (22 men, 19 women; mean age 44.9 years). Twenty-two had chronic CH (CCH) and 19 had episodic CH (ECH). Mean disease duration was 14.1 years (12.3 the CCH group and 15.7 in the ECH group). Overall, 20 (49%) patients were allodynic. There was no statistically significant association between the presence of allodynia and age, gender, diagnosis (episodic vs. chronic CH), disease duration or disease severity. In conclusion, BA was common in this CH patient sample. The therapeutic implications of the presence of BA in CH need to be further studied.

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“…Janks [10] suggested a vasoconstrictive effect to antagonize the "violent dilation" of blood vessels. Hyperoxia with an O 2 partial pressure of 400 mm Hg reduced the plasma protein extravasation ratio (PPE) in rat dura mater from 1.72 under normoxic conditions to 1.14 [12]. Hyperoxia was nearly as effective as sumatriptan (PPE ratio, 1.06).…”

Section: Commentsmentioning

confidence: 99%

Oxygen treatment in acute cluster headache

Jürgens

May²

2009

Current Science Inc

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Effect of Hyperoxia on Neurogenic Plasma Protein Extravasation in the Rat Dura Mater

Cited by 27 publications

References 24 publications

Oxygen Therapy Influences Episodic Cluster Headache and Related Cutaneous Brush and Cold Allodynia

Oxygen Therapy Influences Episodic Cluster Headache and Related Cutaneous Brush and Cold Allodynia

Dynamic mechanical (brush) allodynia in cluster headache: a prevalence study in a tertiary headache clinic

Oxygen treatment in acute cluster headache

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