Effect of hyperprolactinaemia on Toxoplasma gondii prevalence in humans

Dzitko, Katarzyna; Malicki, Sebastian; Komorowski, Jan

doi:10.1007/s00436-007-0824-0

Cited by 19 publications

(22 citation statements)

References 38 publications

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“…Normalization of prolactin levels in patients with migraine found after treatment with VA (Horrobin, 1973;Murialdo & Polleri, 1987) could reflect beneficial effects of killing T. gondii tachyzoites by the drug rather than eventual prolactin role promoting VA efficacy (Horrobin, 1973;Serdaroglu et al, 2002). Recent findings that women with hyperprolactinemia have markedly lower seroprevalence of T. gondii antibodies than those with normal prolactin levels (33.9 vs. 45.58%, p < .025) (Dzitko, Malicki, & Komorowski, 2008) provided further support for this argument.…”

Section: Important Role Of Calcium In T Gondii Tachyzoites Invasion mentioning

confidence: 70%

The Importance of Toxoplasma Gondii Infection in Diseases Presenting With Headaches. Headaches and Aseptic Meningitis May Be Manifestations of the Jarisch-Herxheimer Reaction

Prandota

2009

International Journal of Neuroscience

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Worldwide, approximately 2 billion people are chronically infected with T. gondii with largely unknown consequences. This review presents clinical symptoms, differential diagnosis, triggering factors, treatment, and pathomechanisms responsible for idiopathic intracranial hypertension, pseudotumor cerebri, and aseptic meningitis. Literature cited in this work illustrates that immune state and other biologic mediator imbalances due to various endogenous and exogenous triggering factors may markedly affect latent central nervous system T. gondii infection/inflammation intensity, and cause reactivation of cerebral toxoplasmosis (CT). Irregularities in pro- and anti-inflammatory processes may markedly disturb the host and/or T. gondii defense mechanisms important for immune control of the parasite thereby manifesting as a wide range of neurologic symptoms and signs observed in some patients with migraine, epilepsy, celiac disease, Henoch-Schönlein purpura, and other brain disorders. This is consistent with reactivation of CT in mice after treatment with dexamethasone associated with depression of type T(H)1 immune response, and development of CT after administration of etanercept or other bioproducts. It seems that various types of headaches, epilepsy, aseptic meningitis, systemic adverse reactions to drugs or other substances represent the Jarisch-Herxheimer reaction due to apoptosis of T. gondii tachyzoites. Also development of some brain tumors, such as ependymoma and glioma may be associated with a chronic course of CT. Thus, all these patients should be tested for T. gondii infection.

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Section: Important Role Of Calcium In T Gondii Tachyzoites Invasion mentioning

confidence: 70%

The Importance of Toxoplasma Gondii Infection in Diseases Presenting With Headaches. Headaches and Aseptic Meningitis May Be Manifestations of the Jarisch-Herxheimer Reaction

Prandota

2009

International Journal of Neuroscience

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“…Based on the literature (Benedetto et al 1995(Benedetto et al , 2001) and on our previous results (Dzitko et al 2008), different hypotheses on the potential antiparasitic action of the PRL were considered. Inhibition of tachyzoite proliferation after their pre-incubation with the PRL and lack of such effect when the hormone was added simultaneously with the parasites to host cells suggests that PRL interacts directly with toxoplasma cells.…”

Section: T Gondii Penetration and Parasitophorous Vacuole Formationmentioning

confidence: 99%

The effect of prolactin (PRL) on the growth of Toxoplasma gondii tachyzoites in vitro

et al. 2010

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During the development and effector phases of the anti-Toxoplasma response, the immunological system of a host is involved in several complex interactions with the endocrine system, and prolactin (PRL) is one of the most important hormones involved in immunoregulation. In this work, the influence of the recombinant human prolactin (rhPRL) on the viability, penetration, and intensity of intracellular proliferation of Toxoplasma gondii BK strain in vitro was evaluated. Using one murine (L929) and two human cell lines (Hs27 and HeLa), no toxic effect of the rhPRL on host cells was found (by determining cellular viability using MTT assay). A similar lack of rhPRL cytotoxic activity was found in the case of the extracellular tachyzoites of T. gondii BK. Replication of parasites in the presence of rhPRL was analyzed first by simultaneous addition of the hormone and the parasites into a microculture of the host cells (treatment during infection). No statistically significant changes in the intensity of parasite proliferation in all used host cells were found for a wide range of the hormone concentrations. However, pre-incubation of the tachyzoites with rhPRL resulted in a significant reduction (up to 36.15%) in the replication abilities of the parasite. Further experiments revealed that in fact, the inhibition of replication was caused by a limited capacity of the parasites to penetrate host's cells as demonstrated by the reduced number of infected cells.

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“…Hyperprolactinemia was described as an immunoregulatory factor in various parasite infestations (2,5,9). An in vitro study showed that exogenous recombinant According to these studies, a high level of PRL may be an important factor for preventing toxoplasmosis.…”

Section: Discussionmentioning

confidence: 96%