Effect of Hyperthermia on Experimental Acute Pancreatitis.

Abstract

-Background -Recent studies indicate that hyperthermia can change infl ammatory mechanisms and protect experimental animals from deleterious effects of secretagogue-induced acute pancreatitis. Aim -To evaluate the effects of hyperthermia posttreatment on cerulein-induced acute pancreatitis in rats. Methods -Twenty animals were divided in two groups: group I (n = 10), rats with cerulein-induced acute pancreatitis undergone hyperthermia, and group II (n = 10), animals with cerulein-induced acute pancreatitis that were kept normothermic. In all groups, amylase serum levels, histologic damage, vascular permeability and pancreatic water content were assessed. Acute pancreatitis was induced by administration of two cerulein injections (20 mcg/kg). A single dose of Evans' blue dye was administered along with the second dose of cerulein. All animals also received a subcutaneous injection of saline solution. After this process, animals undergone hyperthermia were heated in a cage with two 100 W lamps. Body temperature was increased to 39.5ºC and maintained at that level for 45 minutes. Normothermia rats were kept at room temperature in a second cage. Results -Control animals had typical edema, serum amylase activity and morphologic changes of this acute pancreatitis model. Hyperthermia post-treatment ameliorated the pancreatic edema, whereas the histologic damage and the serum amylase level remained unchanged. Conclusions -The fi ndings suggest a benefi cial effect of the thermal stress on infl ammatory edema in experimental acute pancreatitis.

Decreased HDL-C Levels as a Predictor of Organ Failure in Acute Pancreatitis in the Emergency Department

“…Showing the following relevance in the present study, it is one of the first detailed studies of the impact of HDL-C as a predictor useful of MOF in patients with AP in ED; likewise, multivariate adjustments were used for predictors of severity and MOF in particular calcium and creatinine in the analysis of results, and patients with AP without any medical treatment were included since lipid-lowering treatments have been reported to be associated with a lower risk of pancreatitis [62]. In addition, studies in animal models suggest that treatment with lipid-lowering agents may be beneficial in both acute pancreatitis and chronic pancreatitis [63,64], so this study is part of the studies that provide valuable information on the predictive capacity of reducing HDL-C levels in AP.…”

Lipid-Modifying Therapies and Risk of Pancreatitis

“…6,49 Furthermore, studies conducted in animal models suggest that statin therapy may be beneficial in both established acute pancreatitis and chronic pancreatitis. [50][51][52] Major guidelines of lipid-modifying therapy such as the National Cholesterol Education Program Third Report of the Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (NCEP ATP III) 8 and the NationalInstituteforHealthandClinicalExcellence (NICE) Type 2 Diabetes guideline 9 suggesttheadditionoffibratetherapy in patients with moderately elevated triglyceride levels and above (Ͼ400 mg/dL and Ͼ500 mg/dL, respectively). This is based on the rationale that hypertriglyceridemiaisawell-recognizedcauseofpancreatitis and that lowering of triglyceride levels should be clinically beneficial.…”

Freqüência de polimorfismos do gene CFTR em pacientes portadores de pancreatite crônica alcoólica

“…5 O álcool também aumenta a sensibilidade do pâncreas à resposta inflamatória pela super regulação dos sistemas mediadores da produção de citosinas e de outras moléculas pró inflamatórias (proteína quinase C, fator nuclear B, proteína ativadora 1, etc), 5 além de gerar espécies reativas de oxigênio (ROS), que atuam como ativadoras das células estreladas do pâncreas. 5 No Brasil, de Almeida et al 6,7 e Andraus et al 8 6,7,8 A quantidade de etanol considerada crítica para determinar o comprometimento crônico do pâncreas é de cerca de 80 e 100g diários, respectivamente para o sexo feminino e para o masculino, por, em média, seis anos; a lesão do pâncreas depende do teor de álcool ingerido e da predisposição à doença apresentada pelo indivíduo. 3 4 A suscetibilidade pancreática ao álcool é variável e apenas 5 a 10 % dos etilistas crônicos desenvolvem pancreatite crônica.…”