Effect of Hyperthermic Preconditioning on the Survival of Ischemia-Reperfused Skin Flaps: A New Skin-Flap Model in the Mouse

Minh, Trinh Cao; Ichioka, Shigeru; Nakatsuka, Takashi; Kawai, Junsuke; Shibata, Masahiro; Ando, Jun; Harii, Kiyonori

doi:10.1055/s-2002-19892

Cited by 15 publications

(9 citation statements)

References 17 publications

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“…Recent research has highlighted differences in wound bacterial colonisation as being important in the development of chronic wounds , and this is now being modelled but remains an emerging area. Researchers have attempted to recreate the effects of local tissue hypoxia in vivo using the skin flap model . Here, a pedicle flap of skin is created with supplying blood vessels severed, creating an ischaemic gradient.…”

Section: What If I Want Something More Complicated?mentioning

confidence: 99%

Animal models of wound repair: Are they cutting it?

Ansell

Holden

Hardman

2012

Experimental Dermatology

119

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Current understanding of the complex process of wound repair is based on decades of study. Integral to this understanding has been the use of in vitro and in vivo models to uncover the key molecular players. Now that major wound processes are more fully understood, therapeutic strategies can be developed to manipulate wound repair. Particularly important areas for future research include developing therapies to aid treatment of healing pathologies such as chronic wounds, and manipulating the normal healing processes to drive a more regenerative phenotype in adults. Here, we discuss the benefits and limitations of current animal-based models and highlight the urgent need for improved predictive preclinical models for wound healing research. We conclude by suggesting directions where more robust models of chronic wound pathologies may arise, expediting the development of novel therapies.

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Section: What If I Want Something More Complicated?mentioning

confidence: 99%

Animal models of wound repair: Are they cutting it?

Ansell

Holden

Hardman

2012

Experimental Dermatology

119

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“…Preconditioning describes the phenomenon of injury induced endogenous protection [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18]. Preconditioning was first described in 1986 when Murry's group [19] noted the effect in canine myocardium.…”

Section: Introductionmentioning

confidence: 99%

Preconditioning: Gender Effects1

Pitcher

Wang

Tsai

et al. 2005

Journal of Surgical Research

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“…We planned to combine our original flap model 1,2 with intravital microscopic techniques, and we developed a new model that allows visualization of¯ap…”

Section: à16mentioning

confidence: 99%

“…1,2 The new model was con®rmed to be useful and to oer certain advantages for the study of ischemia-reperfusion injury.…”

Section: Microsurgery 22:304±310 2002mentioning

confidence: 99%

In vivo model for visualizing flap microcirculation of ischemia‐reperfusion

et al. 2002

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Since ischemia-reperfusion injury continues to be a major problem in reconstructive microsurgery, improvement of experimental models is still desirable. We developed a model that allows direct visualization of flap microcirculation in mice by intravital microscopic techniques. A newly designed skinfold chamber was installed on the dorsum of mice, and microcirculation was inspected with an intravital microscope. An island flap, nourished by the deep circumflex iliac arteries, was elevated after implantation of the chamber, allowing visualization of the microcirculation in the island flap. The island flap was exposed to global ischemia by clamping the pedicles, and the clamps were then released to allow reperfusion. Various microcirculatory responses induced by ischemia-reperfusion were visualized. This model accurately simulated the clinical situation in reconstructive surgery and successfully realized chronic visualization of the flap microcirculation in vivo.

show abstract

Effect of Hyperthermic Preconditioning on the Survival of Ischemia-Reperfused Skin Flaps: A New Skin-Flap Model in the Mouse

Cited by 15 publications

References 17 publications

Animal models of wound repair: Are they cutting it?

Animal models of wound repair: Are they cutting it?

Preconditioning: Gender Effects1

In vivo model for visualizing flap microcirculation of ischemia‐reperfusion

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