Effect of hypobaric hypoxia on the fiber type transition of skeletal muscle: a synergistic therapy of exercise preconditioning with a nanocurcumin formulation

Kushwaha, Asha D; Varshney, Rajeev K.; Saraswat, Deepika

doi:10.1007/s13105-023-00965-1

Cited by 3 publications

(1 citation statement)

References 64 publications

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“…After 14 days of exercise pretreatment, the animals were exposed to a simulated low-pressure anoxic chamber, followed by 7 days of constant treadmill running at a moderate speed of 40 m/min to the point of exhaustion. Under hypoxia exposure, the group that received curcumin with exercise pretreatment had significantly higher ATP levels than the group that received exercise pretreatment alone, and mitochondrial biomarkers (PGC-1α, SIRT1, mitochondrial transcription factor A, and Nrf1) were all improved (Kushwaha et al, 2023). Hypobaric hypoxia has effects on skeletal muscle injury, mitochondrial dysfunction, and muscle fiber turnover, so it is possible that exercise fatigue could also be induced in an environment of hypobaric hypoxia (Chaillou et al, 2014;Rathor et al, 2021).…”

Section: Effects Of Curcumin On Energy Metabolismmentioning

confidence: 99%

Advances in relieving exercise fatigue for curcumin: Molecular targets, bioavailability, and potential mechanism

Zhang,

Kang,

Song

et al. 2024

Journal of Food Science

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Intense and prolonged physical activity can lead to a decrease in muscle capacity, making it difficult to maintain the desired exercise intensity and resulting in exercise fatigue. The long‐term effects of exercise fatigue can be very damaging to the body, so it is an urgent problem to be addressed. The intervention of foodborne active substances will be an effective measure. There is growing evidence that the molecular structure and function of curcumin have a positive effect on relieving fatigue. In this review, we summarize curcumin's molecular structure, which enables it to bind to a wealth of molecular targets, regulate signaling pathways, and thus alleviate exercise fatigue through a variety of mechanisms, including reducing oxidative stress, inhibiting inflammation, reducing metabolite accumulation, and regulating energy metabolism. The effects of curcumin on fatigue‐related markers were analyzed from the perspective of animal models and human models and based on the bidirectional interaction between curcumin and intestinal microbiota: Intestinal microbiota can transform curcumin, and curcumin regulates gut microbiota through metabolic pathways, providing a new perspective for alleviating fatigue. This review contributes to a more comprehensive understanding of the possible molecular mechanisms of curcumin in anti‐fatigue and provides a new possibility for the development of functional foods in the future.

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Section: Effects Of Curcumin On Energy Metabolismmentioning

confidence: 99%

Advances in relieving exercise fatigue for curcumin: Molecular targets, bioavailability, and potential mechanism

Zhang,

Kang,

Song

et al. 2024

Journal of Food Science

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Increased Expression of MiRNA‐1 Contributes to Hypobaric Hypoxia‐Induced Skeletal Muscle Loss

Srivastava,

Mondal,

Rathor

et al. 2023

Advanced Biology

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The present study aims to analyze the role of microRNA‐1 in the regulation of skeletal muscle loss under hypobaric hypoxia (HH). Male Sprague Dawley rats (n = 10) weighing 230–250 g are divided into two groups, control and HH exposure for 7 days at 25 000 ft. After the hypoxia exposure, the animals are sacrificed and hindlimb skeletal muscles are excised for further analysis. Studies found the potential role of miR‐1 (myomiR) as a biomarker under different atrophic conditions. Prolonged exposure to HH leads to enhanced expression of miR‐1 in skeletal muscle as compared to unexposed controls. The Bioinformatics approach is used to identify the validated targets and the biological processes of miR‐1. The target prediction tools identify PAX3 and HSP70 as major targets for miR‐1. Exposure to HH significantly reduces PAX3 and HSP70 expression during 7 days of HH exposure, which further enhances the activity of FOXO3, MSTN, and ATROGIN known for the progression of skeletal muscle atrophy in relation to control rats. This study indicates the increased expressions of miR‐1 and reduced expression of PAX3 and HSP70 lead to impaired myogenesis in skeletal muscle under HH. Further, enhanced expression of muscle degradation genes such as FOXO3, MSTN, and ATROGIN under HH exposure causes skeletal muscle protein loss.

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Oral antioxidant edaravone protects against cognitive deficits induced by chronic hypobaric hypoxia at high altitudes

Ma,

Li,

et al. 2024

Transl Psychiatry

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Effect of hypobaric hypoxia on the fiber type transition of skeletal muscle: a synergistic therapy of exercise preconditioning with a nanocurcumin formulation

Cited by 3 publications

References 64 publications

Advances in relieving exercise fatigue for curcumin: Molecular targets, bioavailability, and potential mechanism

Advances in relieving exercise fatigue for curcumin: Molecular targets, bioavailability, and potential mechanism

Increased Expression of MiRNA‐1 Contributes to Hypobaric Hypoxia‐Induced Skeletal Muscle Loss

Oral antioxidant edaravone protects against cognitive deficits induced by chronic hypobaric hypoxia at high altitudes

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