Effect of hypothyroid status on adenosine 3',5'-monophosphate-dependent protein kinase of rat kidney.

Hagino, Yasumichi; Uematsu, Toshihiko; Tachibana, Masakatsu

doi:10.1254/jjp.31.185

Cited by 3 publications

(3 citation statements)

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“…Moreover, an altered ratio and subcellular distribution of these isozymes were observed in certain pathological con ditions (4)(5)(6)16). We also reported pre viously that in both the renal cortex and medulla, the ratio of type I to type II enzyme in hypothyroid rats was about twice that in the normal rats (7). An altered elution profile on DEAE-cellulose chromatography was also observed in the present muscle preparations.…”

Section: Discussionsupporting

confidence: 75%

“…40 mg of protein) were used for DEAE-cellulose column chromatography. The enzymes were eluted from the column as described previously (7).…”

Section: Methodsmentioning

confidence: 99%

“…In the previous study, we observed an altered ratio of the amount of type I to that of type II in the kidney of hypothyroid rats (7). Moreover, various kinds of myopathy are commonly encountered in patients with hypothyroidism (8).…”

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confidence: 97%

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Effect of hypothyroid status on adenosine 3',5'-mono-phosphate-dependent protein kinase of skeletal, heart and diaphragm muscle of rats.

Hagino

Tachibana

1981

Jpn.J.Pharmacol

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Properties of cyclic AMP-dependent protein kinases from skeletal, heart and diaphragm muscles of hypothyroid rats were compared. Increased enzyme activity was observed in skeletal muscle from hypo thyroid rats after DEAE-cellulose chromatography. Changes in isozyme distribution were also shown in the hypothyroid status. The elution profile on DEAE-cellulose suggested a possible translocation of the enzyme from the particulate to the soluble fraction in the heart of hypothyroid rats. The turnover rate of the enzyme protein decreased in the skeletal muscle of hypothyroid rats, but the other two organs showed no change even in the hypothyroid status. The activity of heat-stable protein kinase inhibitor increased in the skeletal and the diaphragm muscles in hypothyroid rats, whereas the activity in the heart decreased in the hypothyroid status. These data suggested the possibility that changes in enzyme properties, modi fication of isozyme distribution, and changes in modulator activity might account for the modulation of muscle function in hypothyroid rats.

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Section: Discussionsupporting

confidence: 75%

“…40 mg of protein) were used for DEAE-cellulose column chromatography. The enzymes were eluted from the column as described previously (7).…”

Section: Methodsmentioning

confidence: 99%

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Effect of hypothyroid status on adenosine 3',5'-mono-phosphate-dependent protein kinase of skeletal, heart and diaphragm muscle of rats.

Hagino

Tachibana

1981

Jpn.J.Pharmacol

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Effect of Hypothyroid Status on Adenosine 3′,5′-Mono-Phosphate-Dependent Protein Kinase of Skeletal, Heart and Diaphragm Muscle of Rats

Hagino

Tachibana

1981

Japanese Journal of Pharmacology

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Adenosine 3',5'-monophosphate dependent protein kinase of uterus in euthyroid and hypothyroid rats.

1984

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Effect of hypothyroid status on adenosine 3',5'-monophosphate-dependent protein kinase of rat kidney.

Abstract: Abstract-Changes in the properties of cyclic AM P-dependent protein kinasewere studied in the kidney of hypothyroid rats.

Cited by 3 publications

References 27 publications

Effect of hypothyroid status on adenosine 3',5'-mono-phosphate-dependent protein kinase of skeletal, heart and diaphragm muscle of rats.

Effect of hypothyroid status on adenosine 3',5'-mono-phosphate-dependent protein kinase of skeletal, heart and diaphragm muscle of rats.

Effect of Hypothyroid Status on Adenosine 3′,5′-Mono-Phosphate-Dependent Protein Kinase of Skeletal, Heart and Diaphragm Muscle of Rats

Adenosine 3',5'-monophosphate dependent protein kinase of uterus in euthyroid and hypothyroid rats.

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