Effect of Hypoxia and Hypercapnic Acidosis on Renal Autoregulation in the Dog: Role of Renal Nerves

Pluss, Richard G.; Pluss, William T.; Bell, Jonathan; Zerbe, Gary

doi:10.1042/cs0650533

Cited by 11 publications

(5 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The changes in RBF observed in our experiments can thus be due to a direct stimulation of the renin-angiotensin system by hypercapnia, or to a stimulation via the renal nerves as suggested by different authors (7,12,13,15,20).…”

Section: Discussionsupporting

confidence: 57%

“…The PAH extraction values were comparable to those observed in normocapnic animals, thus demonstrating that hypercapnia does not change PAH extraction, and that the drop in C PAH corresponds to a true decrease in RBF. A 10% decrease in PAH extraction was observed by Anderson et al (11,12) during hypercapnic acidosis in dogs, but was apparently not found in other studies ofthe same group (13,14), nor was any change in PAH extraction HEIJDEN AND GUIGNARD during hypercapnia mentioned by Norman et al (7) and by Berns et al (15). This is in agreement with studies using either a sine wave electromagnetic flowmeter (6) or microspheres (4,5) for measuring RBF.…”

Section: Discussionmentioning

confidence: 79%

See 1 more Smart Citation

Effect of Hypercapnic Acidosis on Renal Function in the Newborn Rabbit

Heijden

Guignard

1986

Pediatr Res

View full text Add to dashboard Cite

Anaesthetized mechanically ventilated newborn rabbits were exposed to different degrees of hypercapnia. One hour of normocapnia was used as a control period. Renal function studies demonstrated an increase in renal vascular resistance with a concomitant decrease in effective renal plasma flow in all hypercapnic animals, combined with a less pronounced decrease in glomerular filtration rate. Filtration fraction rose significantly. A decrease in systemic blood pressure was only observed when the PaCO2 exceeded 100 mm Hg combined with an arterial pH below or equal to 7.10. We conclude that normoxemic hypercapnia in the newborn rabbit leads to an increase in renal vascular resistance and suggest that the renal vasoconstriction predominates at the level of the efferent arteriole.

show abstract

Section: Discussionsupporting

confidence: 57%

Section: Discussionmentioning

confidence: 79%

Effect of Hypercapnic Acidosis on Renal Function in the Newborn Rabbit

Heijden

Guignard

1986

Pediatr Res

View full text Add to dashboard Cite

show abstract

“…Anderson et al 47 reported that hypercapnic acidosis can decrease renal blood flow and GFR during the period when renal perfusion pressure decreases from 125 to 75 mm Hg. The amount of acidosis reached in that study (pH 7.03 ± 0.01) was more extreme than in the study reported here during anesthesia (pH 7.18 ± 0.04).…”

Section: Discussionmentioning

confidence: 99%

Effects of carprofen on renal function and results of serum biochemical and hematologic analyses in anesthetized dogs that had low blood pressure during anesthesia

Boström¹,

Nyman²,

Lord³

et al. 2002

ajvr

View full text Add to dashboard Cite

show abstract

“…For example, systemic hypoxia has been reported to induce antidiuresis and antinatriuresis in anaesthetized dogs (Anderson et at. 1978;Bruns, 1978;Anderson, Pluss, Pluss, Bell & Zerbe, 1983), fetal lambs (Nakamura, Ayres, Gomez & Robillard, 1985), unanaesthetized rats (Behm, Mewes, DeMuinck Keizer, Unger & Rettig, 1993), and some human subjects (Honig, 1989). In contrast, diuresis and natriuresis has been reported in unanaesthetized dogs and anaesthetized rats (Walker, 1982;Rose, Althaus, Kaiser, Miller & Carey, 1983;Colice, Yen, Ramirez, Dietz & Ou, 1991) and in humans (Ullman, 1961;Koller, Buhrer, Felder, Schopen & Vallotten, 1991).…”

mentioning

confidence: 99%

The effects of systemic hypoxia on renal function in the anaesthetized rat.

Neylon

Marshall

Johns

1995

The Journal of Physiology

View full text Add to dashboard Cite

1. In rats anaesthetized with Saffan, renal function was monitored from the left kidney from the 5th minute of spontaneous breathing of 12% 02 for two 20 min periods and during air breathing before, between and after the hypoxic periods. Two groups of animals (I and II) were used, each group comprising two subgroups in which the left kidney was innervated or denervated, respectively; in Group II, renal perfusion pressure (RPP) was maintained during the 2nd hypoxic period by occl97uding the distal aorta.2. In both subgroups of Group I, both hypoxic periods produced hyperventilation, arterial P02falling to -50 mmHg. Concomitantly, mean arterial pressure (MABP) fell by similar extents (-23 %, from a baseline level of 140 mmHg during the 2nd hypoxic period). In the innervated subgroup, renal vascular conductance (RVC) increased, but glomerular filtration rate (GFR) fell (by 48 and 6%, respectively, during the 2nd hypoxic period), while urine flow, absolute sodium excretion (UNa V) and fractional sodium excretion (FENa) fell (by 52, 63 and 61 %, respectively). Baseline urine flow, UN. V and FENa were higher in the denervated subgroup, but hypoxia produced similar percentage changes from baseline in all variables. 3. In Group II, both subgroups showed similar changes during the 1st hypoxic period as the corresponding subgroups of Group I. However, during the 2nd hypoxic period when the fall in MABP was reduced to 7%, the increase in RVC persisted only in the denervated subgroup; there was no significant change in GFR, urine flow, UNaV or FENa in either subgroup. 4. These results indicate that, in the rat, moderate hypoxia produces antidiuresis and antinatriuresis that are not dependent on the renal nerves, but are dependent on the hypoxiainduced fall in MABP. The fall in renal perfusion pressure (RPP) may directly determine renal function, but reflex influences upon the kidney initiated by, for example, arterial baroreceptor unloading, may play a role. The fall in GFR and increase in RVC, which persisted after denervation or when renal perfusion was controlled, implies a local dilatatory influence acting preferentially on the efferent arterioles.It is recognized that systemic hypoxia can have pronounced effects on renal function. However, these effects are controversial. For example, systemic hypoxia has been reported to induce antidiuresis and antinatriuresis in anaesthetized dogs (Anderson et at.

show abstract

Effect of Hypoxia and Hypercapnic Acidosis on Renal Autoregulation in the Dog: Role of Renal Nerves

Cited by 11 publications

References 10 publications

Effect of Hypercapnic Acidosis on Renal Function in the Newborn Rabbit

Effect of Hypercapnic Acidosis on Renal Function in the Newborn Rabbit

Effects of carprofen on renal function and results of serum biochemical and hematologic analyses in anesthetized dogs that had low blood pressure during anesthesia

The effects of systemic hypoxia on renal function in the anaesthetized rat.

Contact Info

Product

Resources

About