2015
DOI: 10.1134/s0022093015020039
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Effect of hypoxia on cholinesterase activity in rat sensorimotor cortex

Abstract: This study reports the dynamics of changes in postnatal ontogenesis of the activity of soluble and membrane-bound forms of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) in the sensorimotor cortex of rats as well as the character of their changes after prenatal hypoxia (Е14, 7% О 2 , 3 hours) or acute hypoxia in adult animals (4 months, 7% О 2 , 3 hours). In normally developing rats the activity of the membrane-bound form of AChE in the sensorimotor cortex gradually increased up to the end of the… Show more

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Cited by 10 publications
(6 citation statements)
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“…Structural and functional changes in rat brain after prenatal hypoxia are underlined by significant alterations in its biochemical characteristics including various classes of molecules (nucleic acids, proteins and lipids) and metabolic pathways (Gross et al, 1981 ; White and Lawson, 1997 ; Peyronnet et al, 2000 ; Beltran-Parrazal et al, 2010 ; Camm et al, 2011 ). For example, acute prenatal hypoxia on E14 affects activities of the different forms (cytosolic, membrane-bound, and soluble) of acetyl- and butyryl-cholinesterases (AChE and BChE) in the sensorimotor cortex detected at various stages of postnatal ontogenesis (Lavreneva et al, 2003 ; Kochkina et al, 2015 ). The increase in brain BChE activity might have a compensatory effect on the stress response of the brain due to the enzyme's ability for hydrolysing various toxic agents (for review see Lockridge, 2015 ).…”
Section: Prenatal Hypoxia In Ratsmentioning
confidence: 99%
“…Structural and functional changes in rat brain after prenatal hypoxia are underlined by significant alterations in its biochemical characteristics including various classes of molecules (nucleic acids, proteins and lipids) and metabolic pathways (Gross et al, 1981 ; White and Lawson, 1997 ; Peyronnet et al, 2000 ; Beltran-Parrazal et al, 2010 ; Camm et al, 2011 ). For example, acute prenatal hypoxia on E14 affects activities of the different forms (cytosolic, membrane-bound, and soluble) of acetyl- and butyryl-cholinesterases (AChE and BChE) in the sensorimotor cortex detected at various stages of postnatal ontogenesis (Lavreneva et al, 2003 ; Kochkina et al, 2015 ). The increase in brain BChE activity might have a compensatory effect on the stress response of the brain due to the enzyme's ability for hydrolysing various toxic agents (for review see Lockridge, 2015 ).…”
Section: Prenatal Hypoxia In Ratsmentioning
confidence: 99%
“…AchE activity was maintained in the brain during the postnatal period, and THs could regulate its activity through their action on nerve growth factor or through their genomic and non-genomic actions [60]. Furthermore, GH and IGF (neurotrophic and neuroprotective factors) axis could regulate its activity during pre-and post-weaning periods [61].…”
Section: Discussionmentioning
confidence: 99%
“…Thus, in postnatal ontogenesis of hypoxic rats, the activity of acetyl-and butyrylcholinesterases (AChE and BChE) in the sensorimotor cortex had a significantly different dynamics compared to controls [68]. Apart from decreased activity of these enzymes during the first month of postnatal ontogenesis (and active formation of synaptic contacts), there were also significant changes in the distribution of the membrane-bound (involved in signal transduction) and soluble (participating in synaptogenesis [69]) forms of AChE.…”
Section: Changes At the Molecular And Biochemical Levelsmentioning
confidence: 96%