Effect of hypoxia on mitochondrial enzymes and ultrastructure in the brain cortex of rats with different tolerance to oxygen shortage

Transport of Ca2+ and Ca2+-Dependent Permeability Transition in the Liver and Heart Mitochondria of Rats with Different Tolerance to Acute Hypoxia

“…At the same time, the organelles of the liver of HR rats become more resistant to the opening of the Ca 2+ -dependent MPT pore in comparison with those of LR rats. Along with the well-characterized distinction in the intensity of OXPHOS in mitochondria of the vital organs of LR and HR rats [18,25], these effects might contribute to the development of individual systemic resistance of animals to acute hypoxia.…”

“…It is well known that individuals of an animal population differ in their tolerance to oxygen deficiency [15][16][17]25]. As shown earlier, animals that belong to two opposite, in regard to hypoxia tolerance, types (LR and HR) have essentially different "functional-metabolic" profiles, including the effectiveness of energy support of the organism, the regulation of central nervous cardiovascular systems, neurohumoral regulation, stress-activating and stress-limiting systems, the oxygen-transporting function of blood, and the state of membranes and receptors.…”

“…It was previously shown that mitochondria of the vital organs of LR and HR rats differ in both structural and basic functional parameters. Thus, the mitochondria of the cerebral cortex of HR rats are characterized by a denser packing of cristae and a more electron-dense matrix, smaller sizes, and higher concentrations of the respiratory chain complexes and the respiration substrate, succinate (i.e., they are functionally more active compared to mitochondria of LR rats) [16,25]. In contrast, in brain mitochondria of LR rats, the number of mitochondrial cristae is decreased, and this is consistent with the lower content of their respiratory electron carriers compared to mitochondria of HR rats.…”

Differences in Tolerance to Hypoxia: Physiological, Biochemical, and Molecular-Biological Characteristics

“…Clinical and pathophysiological studies, focused on the research on the effect of high-altitude conditions on the organism, made it possible to distinguish two polar groups of laboratory animals and humans according to their ability to adapt to the lack of oxygen and differences in their basic resistance to hypoxia [ 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 ]. In experimental studies, according to the results of the survival time (the time before respiratory disturbances and signs of asphyxia appear) in an assessment under conditions of hypobaric hypoxia, animals are divided into tolerant and susceptible to oxygen deficiency.…”

“…Oxygen deficiency is one of the key factors in the development of infectious, inflammatory, and tumor diseases [ 1 , 2 , 3 , 4 , 5 , 6 ]. It is known that basic tolerance to hypoxia in humans and various animal species differs [ 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 ]. The differences in basic tolerance to oxygen deficiency can determine the predisposition to the development of hypoxia-related disorders.…”