Effect of<i>Aloe vera</i>. on Rat Pulp Tissue

Gala-García, Alfonso; Teixeira, Karina Imaculada Rosa; Mendes, Larissa Loures; Sobrinho, Antônio Paulino Ribeiro; Santos, Vagner Rodrigues; Cortés, María Esperanza

doi:10.1080/13880200801887138

Cited by 12 publications

(16 citation statements)

References 23 publications

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“…A metal foil interface (stainless platinum, 2 mm diameter) was used to prevent detrimental discharge of ionic mercury contained in the final amalgam restorative material (Velvalloy, S.S. White, Ltd., Rio de Janeiro, Rio de Janeiro, Brazil). [11][12]…”

Section: Animalsmentioning

confidence: 99%

Bioceramic/Poly (glycolic)-poly (lactic acid) composite induces mineralized barrier after direct capping of rat tooth pulp tissue

Gala-García

Teixeira

Wykrota³

et al. 2010

Braz. oral res.

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The aim of this study was to observe the histopathological pulp response following direct pulp capping of mechanically exposed teeth in rats with a composite of beta-tricalcium phosphate-hydroxyapatite bioceramic (BC) and poly (glycolic)-poly (lactic acid) (PLGA) material or a calcium hydroxide [Ca(OH)2] material, compared to BC alone and a negative control of water. Pulp of the maxillary molars was exposed, followed by capping with the experimental material. The pulpal tissue response was assessed post-operatively at 1, 7, 14 and 30 d, followed by histological analysis. The Ca(OH)2 group exhibited severe acute inflammatory cell infiltration at day 14. However after 30 d, a new hard tissue with macro porous obliteration of the pulp chamber and a characteristic necrotic area had appeared. BC and Ca(OH)2 capping were associated with moderate inflammation and dentinal bridge similar. Meanwhile, in the BC/PLGA composite group, there was moderate inflammatory infiltrate and formation of a dense and complete dentinal bridge. In conclusion, the BC/PLGA composite material showed a large zone of tertiary dentin, and effectively reorganized the dentin-pulp complex

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Section: Animalsmentioning

confidence: 99%

Bioceramic/Poly (glycolic)-poly (lactic acid) composite induces mineralized barrier after direct capping of rat tooth pulp tissue

Gala-García

Teixeira

Wykrota³

et al. 2010

Braz. oral res.

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“…39 In an animal model, Gala-Garcia et al, evaluated the effect of AV on rat pulp tissue and found that they have superior biocompatibility and potential to form tertiary dentinal bridge formation. 40 …”

Section: Discussionmentioning

confidence: 99%

Clinical and Radiographic Evaluation of Aloe vera vs Formocresol as a Pulpotomy Medicament in Primary Molars: A Double Blinded Randomized Controlled Trial

Subramanyam¹,

Somasundaram

2020

International Journal of Clinical Pediatric Dentistry

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Aim The aim of this clinical trial is to compare the clinical and radiographic success of Aloe vera and formocresol (FC) as a pulpotomy medicament in primary molars. Materials and methods A total of 72 asymptomatic or symptomatic vital primary molars were selected and were assigned to two groups: group II: Buckley's FC, group II: Aloe vera gel. The clinical and radiographic success were evaluated using Zurn and Seale criteria. The data were statistically analyzed using the Chi-square test. Results At three and 6 months follow-up, the clinical success rate of Aloe vera and FC was equally effective. Aloe vera showed a higher radiographic success rate compared to FC ( p > 0.05). At 6 months follow-up, FC showed a higher radiographic success rate compared to Aloe vera ( p > 0.05). Conclusion The clinical and radiographic success of both groups were equally effective at the end of 6 months follow-up. Aloe vera can be considered as an alternative pulpotomy medicament to FC. But, further long-term follow-up studies and histological studies are required. How to cite this article Subramanyam D, Somasundaram S. Clinical and Radiographic Evaluation of Aloe vera vs Formocresol as a Pulpotomy Medicament in Primary Molars: A Double Blinded Randomized Controlled Trial. Int J Clin Pediatr Dent 2020;13(2):138–143.

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“…A preliminary study [18] that assessed the presence of dentin bridges found that over 90 % of the BCP/PLGA samples showed the presence of dentin bridging and that inflammation was resolved after 30 days. The important effects of HA and b-TCP can be seen in their ability to enhance bone growth, both across a gap and around an implant.…”

Section: Discussionmentioning

confidence: 99%

“…This study was performed according to a previously described protocol [11,18]. Approval for this research was obtained from the Institutional Ethics Committee for Animal Research of Federal University of Minas Gerais.…”

Section: Evaluations Of In Vivo Pulp Responsementioning

confidence: 99%

In vitro and in vivo evaluation of the biocompatibility of a calcium phosphate/poly(lactic-co-glycolic acid) composite

Gala-García

Carneiro

Silva

et al. 2012

J Mater Sci: Mater Med

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This study assess the effects of bioceramic and poly(lactic-co-glycolic acid) composite (BCP/PLGA) on the viability of cultured macrophages and human dental pulp fibroblasts, and we sought to elucidate the temporal profile of the reaction of pulp capping with a composite of bioceramic of calcium phosphate and biodegradable polymer in the progression of delayed dentine bridge after (30 and 60 days) in vivo. Histological evaluation of inflammatory infiltrate and dentin bridge formation were performed after 30 and 60 days. There was similar progressive fibroblast growth in all groups and the macrophages showed viability. The in vivo study showed that of the three experimental groups: BCP/PLGA composite, BCP and calcium hydroxide (Ca(OH)(2)) dentin bridging was the most prevalent (90 %) in the BCP/PLGA composite after 30 days, mild to moderate inflammatory response was present throughout the pulp after 30 days. After 60 days was observed dentine bridging in 60 % and necrosis in 40 %, in both groups. The results indicate that understanding BCP/PLGA composite is biocompatible and by the best tissue response as compared to calcium hydroxide in direct pulp capping may be important in the mechanism of delayed dentine bridge after 30 and 60 days.

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Effect ofAloe vera. on Rat Pulp Tissue

Abstract: Aloe vera L. (Aloeaceae) has been extensively studied for anti-inflammatory, antimicrobial, and cellular regeneration properties. This work evaluated in vivo the effects of

Cited by 12 publications

References 23 publications

Bioceramic/Poly (glycolic)-poly (lactic acid) composite induces mineralized barrier after direct capping of rat tooth pulp tissue

Bioceramic/Poly (glycolic)-poly (lactic acid) composite induces mineralized barrier after direct capping of rat tooth pulp tissue

Clinical and Radiographic Evaluation of Aloe vera vs Formocresol as a Pulpotomy Medicament in Primary Molars: A Double Blinded Randomized Controlled Trial

In vitro and in vivo evaluation of the biocompatibility of a calcium phosphate/poly(lactic-co-glycolic acid) composite

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