Effect of
 Alpinia galanga
 on Mental Alertness and Sustained Attention With or Without Caffeine: A Randomized Placebo-Controlled Study

Srivastava, S. N.; Mennemeier, Mark; Pimple, Surekha

doi:10.1080/07315724.2017.1342576

Cited by 17 publications

(9 citation statements)

References 40 publications

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“…These results are in line with prior studies that have examined the effect of adaptogens on human performance [26,28,[62][63][64]. If the study had been conducted for a longer period of time (i.e., 2.5-3 h post consumption) and the trend in improvements in cognitive task performance, vigor, and mental energy continued we may have noted a similar trend in enhanced alertness and mental energy as that recently reported by Srivastava and colleagues who also compared several treatments including a caffeinated comparator, an herbal preparation, and the herbal preparation containing caffeine and noted similar multifactorial interactions on measures of mental alertness and sustained attention [65].…”

Section: E+ Shot Vs Active Comparatorsupporting

confidence: 86%

Caffeine-Containing, Adaptogenic-Rich Drink Modulates the Effects of Caffeine on Mental Performance and Cognitive Parameters: A Double-Blinded, Placebo-Controlled, Randomized Trial

et al. 2020

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Using a placebo-controlled, double-blinded, within-participants, randomized, cross-over design, we examined the neurocognitive effects of a: (a) caffeine-containing, adaptogenic herbal-rich natural energy shot (e+ shot), (b) a matched caffeine-containing shot (caffeine), and, (c) a placebo. Participants (n = 30) were low consumers of caffeine without elevated feelings of energy. Before and three times after beverage consumption, a 27-min battery was used to assess motivation to perform cognitive tasks, mood, attention ((serial subtractions of 3 (SS3) and 7 (SS7), the continuous performance task (CPT), and the rapid visual input processing tasks)), heart rate (HR), blood pressure (BP), and motor coordination (nine-hole peg test) with a 10-min break between each post-consumption battery. The procedure was repeated for each beverage for each participant at least 48 h apart and within 30 min the same time of day using a random group assignment with blinding of researchers and subjects. To evaluate for changes in outcomes, a Treatment × Time analysis of covariance controlling for hours of prior night’s sleep was used. Analysis of all outcomes and all treatment comparisons indicated that compared to placebo, both e+ shot ( Δ ¯ = 2.60; η2 = 0.098) and caffeine ( Δ ¯ = 5.30, η2 = 0.098) increased systolic BP 30 min post consumption (still within normal healthy ranges). The caffeine beverage also led to an improvement in most cognitive measures and moods 30-min post-consumption with improvements tapering at 69 and 108 min, while e+ shot noted more steady improvements with no significant differences between beverages on most cognitive and mood measures at 69 and 108 min. However, compared to caffeine, e+shots noted a significant decrease in reaction time at 108 min, while caffeine noted a small change in the opposite direction. No side-effects were reported by any intervention. These results suggest that the specific blend of adaptogens in e+ shot may modulate the neurocognitive effects of caffeine on mood, and cognition.

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Section: E+ Shot Vs Active Comparatorsupporting

confidence: 86%

Caffeine-Containing, Adaptogenic-Rich Drink Modulates the Effects of Caffeine on Mental Performance and Cognitive Parameters: A Double-Blinded, Placebo-Controlled, Randomized Trial

et al. 2020

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“…When combined, EnXtra + caffeine did not impact the error rate as significantly as stand-alones (decrease of 7.9% [1 hour] and 8.6% [3 hours], with an increase of 6.6% by 5 hours); however, the combination remained effective in averting the caffeine crash, in a similar way as that demonstrated by the previous published study. 3 Figure 2 summarizes the percentage change in error rate from baseline.…”

Section: Discussionmentioning

confidence: 99%

“…The nootropic effect of A. galanga has also been well explored; 2 however, EnXtra, a proprietary extract of A. galanga (E-AG-01), has been proven in a clinical study to be an efficient psychostimulant. 3 In this randomized, placebo-controlled crossover study, effect of EnXtra on the attention network was studied using Fan et al's attention-network test (ANT). 4 The ANT is a widely used tool in psychophysiology to understand attention processes (alerting, orienting, and executing effects).…”

Section: Introductionmentioning

confidence: 99%

Selective enhancement of focused attention by Alpinia galanga in subjects with moderate caffeine consumption

Srivastava¹

2018

OAJCT

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Introduction: The purpose of the secondary analysis of the data from the clinical trial "A Study to Evaluate Efficacy of IP on Alertness and Mental Fatigue" (ClinicalTrials.gov NCT02816827) was to investigate the effect of the Alpinia galanga proprietary extract E-AG-01 (EnXtra) on focused attention, in comparison with caffeine and placebo in moderate caffeine habitués. Participants and methods: A total of 59 caffeine-habituated healthy young adults (aged 18-40 years) with body-mass index of 18.5-25.0 kg/m 2 were crossed over in four interventional groups: placebo, E-AG-01, caffeine, and a combination of caffeine and E-AG-01. All participants completed the attention-network test, which measures the accuracy and speed factors of the alerting, orienting, and executive-control networks. Results: The results of accuracy parameters in terms of percentage-error rate showed a remarkable difference between E-AG-01 and the other treatment groups, wherein the error rate dropped by 1.63% (1 hour), 1.32% (3 hours), and 0.78% (5 hours) from baseline. The caffeine group demonstrated a decrease of 0.37% (1 hour) and 0.44% (3 hours), followed by an increase of 0.2% (5 hours), whereas the error rate of subjects in the caffeine + E-AG-01 group decreased by 0.24% (1 hour) and 0.26% (3 hours), followed by an increase of 0.2% at 5 hours. The placebo group exhibited an increase of 0.14% (3 hours) and 0.77% (5 hours). Conclusion: These results show that E-AG-01 exhibited selectively enhanced focused attention to a higher extent in comparison with caffeine and placebo.

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“…Based on the reported neuroprotective [23] and the CNS stimulant [24] activities of A. galanga, Enovate Biolife explored the potentials of different extract for psychostimulant action via a pilot study [8]. The aqueous extract of A. galanga was found to be the most efficient in enhancing the mental alertness which was further assessed by a well-designed clinical study in the human population [9]. The findings indicated that the current extract central nervous system activity [25].…”

Section: Discussionmentioning

confidence: 99%

“…The extract marketed as EnXtra ® has been clinically proven to improve the mental alertness [8] [9]. The current research was conducted by Enovate Biolife, to discover the mechanism of potential nootropic compounds through their interaction with various targets (Dopamine and Acetylcholinesterase) involved in psychoactive functions.…”

Section: Introductionmentioning

confidence: 99%

Molecular Docking Studies of Alpinia galanga Phytoconstituents for Psychostimulant Activity

Sivanandan¹,

Pimple²

2018

ABC

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Dopamine is a neurotransmitter responsible for sending signals from the central nervous system. It allows human beings to stay attentive and focused. Caffeine, the most widely consumed psychoactive substance in the world, is known to improve alertness by enhancing dopamine signaling in the brain. EnXtra ® , an Alpinia galanga extract has been clinically proven to promote alertness however the mechanism for such action required elucidation. The current study was designed to explore the mechanism for the neurocognitive enhancing property of EnXtra ® by the in-silico interaction of its potential compounds with various targets involved in such process namely Dopamine and Acetylcholinesterase (AchE). As evident by the outcomes of the study, active compounds of EnXtra ® can block the dopamine reuptake thereby increasing the dopamine levels which further can enhance the visuospatial performance and mental clarity, leading to improved mental alertness. At the same time, its strong effect on Acetylcholinesterase target protein is indicative of its nootropic potential.

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Effect of Alpinia galanga on Mental Alertness and Sustained Attention With or Without Caffeine: A Randomized Placebo-Controlled Study

Cited by 17 publications

References 40 publications

Caffeine-Containing, Adaptogenic-Rich Drink Modulates the Effects of Caffeine on Mental Performance and Cognitive Parameters: A Double-Blinded, Placebo-Controlled, Randomized Trial

Caffeine-Containing, Adaptogenic-Rich Drink Modulates the Effects of Caffeine on Mental Performance and Cognitive Parameters: A Double-Blinded, Placebo-Controlled, Randomized Trial

Selective enhancement of focused attention by <em>Alpinia galanga</em> in subjects with moderate caffeine consumption

Molecular Docking Studies of <i>Alpinia galanga</i> Phytoconstituents for Psychostimulant Activity

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Effect of Alpinia galanga on Mental Alertness and Sustained Attention With or Without Caffeine: A Randomized Placebo-Controlled Study

Cited by 17 publications

References 40 publications

Caffeine-Containing, Adaptogenic-Rich Drink Modulates the Effects of Caffeine on Mental Performance and Cognitive Parameters: A Double-Blinded, Placebo-Controlled, Randomized Trial

Caffeine-Containing, Adaptogenic-Rich Drink Modulates the Effects of Caffeine on Mental Performance and Cognitive Parameters: A Double-Blinded, Placebo-Controlled, Randomized Trial

Selective enhancement of focused attention by <em>Alpinia galanga</em> in subjects with moderate caffeine consumption

Molecular Docking Studies of &lt;i&gt;Alpinia galanga&lt;/i&gt; Phytoconstituents for Psychostimulant Activity

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Molecular Docking Studies of <i>Alpinia galanga</i> Phytoconstituents for Psychostimulant Activity